Affinity Data by PDB ID

PDB code 5U4B

Found 1 hit Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Transthyretin (127/127 = 100%)^† (Homo sapiens (Human))	BDBM50241604 (CHEMBL4060726) Show SMILES OC(=O)c1cccc(\C=C\c2ccc(O)cc2)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Competitive binding affinity to human wild type TTR expressed in Escherichia coli BL-21 assessed as equilibrium dissociation constant of second site ...				J Med Chem 60: 7820-7834 (2017) Article DOI: 10.1021/acs.jmedchem.7b00952 BindingDB Entry DOI: 10.7270/Q26W9D7Z
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output