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Found 18 Enz. Inhib. hit(s) for PDB: 1RK3

Vitamin D3 receptor(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL

BDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)

Ki: 0.0400nMAssay Description:Displacement of [3H]1alpha,25-(OH)2D3 from full-length recombinant rat VDR by scintillation counterMore data for this Ligand-Target Pair

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3D Structure (crystal)

Vitamin D3 receptor(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL

BDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)

Ki: 0.0500nMAssay Description:Displacement of [3H]1alpha,25-(OH)2D3 from rat recombinant full length VDRMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

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3D Structure (crystal)

Vitamin D3 receptor(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL

BDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)

Ki: 0.100nMAssay Description:Displacement of [3H]-1alpha,25(OH)2D3 from recombinant rat VDR by scintillation countingMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

Vitamin D3 receptor(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL

BDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)

Ki: 0.100nMAssay Description:Displacement of [3H]-1alpha25-(OH)2D3 from full length recombinant rat vitamin D receptor by scintillation counting analysisMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

Vitamin D3 receptor(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL

BDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)

Ki: 0.100nMAssay Description:Displacement of [3H]1alpha,25-(OH)2D3 from rat recombinant full length VDRMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

Vitamin D3 receptor(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL

BDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)

Ki: 0.100nMAssay Description:Displacement of [3H]1alpha,25-(OH)2D3 from rat recombinant full length VDRMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

Vitamin D3 receptor(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL

BDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)

Ki: 0.100nMAssay Description:Displacement of [3H]1alpha,25-(OH)2D3 from rat recombinant full length VDRMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

Vitamin D3 receptor(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL

BDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)

Ki: 0.100nMAssay Description:Displacement of radiolabelled 1alpha, 25-(OH)2D3 from recombinant rat VDRMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

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CHEMBL DrugBank MCE
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Details Article PubMed PDB

3D Structure (crystal)

Vitamin D3 receptor(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL

BDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)

Ki: 0.100nMAssay Description:Displacement of [3H]-1alpha,25(OH)2D3 from recombinant rat VDR after overnight incubation by scintillation countingMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

Vitamin D3 receptor(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL

BDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)

Ki: 0.100nMAssay Description:Displacement of radiolabeled 1alpha,25-(OH)2D3 from rat recombinant full length VDRMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

Vitamin D3 receptor(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL

BDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)

Ki: 0.200nMAssay Description:Activity at rat recombinant full length VDR expressed in rat ROS 17/2.8 cells transfected with 24-hydroxylase gene promoter assessed as transcription...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

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CHEMBL DrugBank MCE
KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

Vitamin D3 receptor(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL

BDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)

EC50: 0.100nMAssay Description:Displacement of [3H]1,25-(OH)2D3 from rat recombinant His-tagged VDR ligand-binding domain expressed in Escherichia coli BL21More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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B.MOAD GoogleScholar

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CHEMBL DrugBank MCE
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3D Structure (crystal)

Vitamin D3 receptor(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL

BDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)

EC50: 0.0500nMAssay Description:Displacement of 1-alpha,25-dihydroxyvitamin from rat recombinant VDRMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
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3D Structure (crystal)

Vitamin D3 receptor(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL

BDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)

EC50: 0.200nMAssay Description:Activity at VDR in rat osteosarcoma cells assessed as 24-hydroxylase transcription by reporter gene assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

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CHEMBL DrugBank MCE
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Details Article PubMed PDB

3D Structure (crystal)

Vitamin D3 receptor(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL

BDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)

EC50: 0.200nMAssay Description:Agonist activity at rat VDR in ROS 17/2.8 cells transfected with Cyp24a1 reporter plasmid assessed as increase in Cyp24a1 transcription after 16 hrs ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

Vitamin D3 receptor(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL

BDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)

EC50: 0.300nMAssay Description:Activity at VDR in rat osteosarcoma cells assessed as induction of 24-hydroxylase reporter gene transcription by luciferase reporter gene assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

Vitamin D3 receptor(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL

BDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)

EC50: 0.200nMAssay Description:Activity at VDR in rat ROS 17/2.8 cells assessed as transcriptional activation of 24-hydroxylase gene promoter after 16 hrs by luciferase reporter ge...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

Vitamin D3 receptor(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL

BDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)

EC50: 0.200nMAssay Description:Activity at rat recombinant full length VDR expressed in rat ROS 17/2.8 cells transfected with 24-hydroxylase gene promoter assessed as transcription...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

Filter my 18 hits

Targets 1▿
- Vitamin D3 receptor 18
Publications 12▿
- Bioorg Med Chem 17: 7658-69 (2009) 2
- J Med Chem 50: 6154-64 (2007) 2
- J Med Chem 53: 8642-9 (2010) 2
- Bioorg Med Chem 16: 8563-73 (2008) 2
- Bioorg Med Chem 19: 7205-20 (2011) 2
- Bioorg Med Chem 17: 1747-63 (2009) 2
- J Med Chem 58: 6237-47 (2015) 1
- J Med Chem 54: 6832-42 (2011) 1
- J Med Chem 55: 4352-66 (2012) 1
- J Med Chem 58: 9731-41 (2015) 1
- J Med Chem 52: 3496-504 (2009) 1
- Bioorg Med Chem 16: 457-73 (2008) 1
Institutions 3▿
- University Of Wisconsin-Madison 15
- University Of Warsaw 2
- Tokyo Medical And Dental University 1
Affinity: 0.040 to 0.30 nM▿
- Ki 11
- EC50 7
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1