Found 69 Enz. Inhib. hit(s) for PDB: 2PDK 
Affinity DataIC50: 17nMAssay Description:Inhibition of crude aldose reductase of rat lensMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 17nMAssay Description:Compound was tested for inhibitory concentration against rat lens aldose reductase (uncompetitive inhibition type)More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Compound was tested for its ability to inhibit crude aldose reductase obtained from rat lensMore data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition of Sprague-Dawley rat kidney ALR1 using sodium D-glucuronate as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:In vitro inhibition of rabbit lens aldose reductase.More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:The compound was tested for the inhibition of Aldose reductase in rat lens assay.More data for this Ligand-Target Pair
Affinity DataIC50: 73nMAssay Description:Concentration required to produce 50% inhibition of aldose reductase enzyme (the literature IC50 value for sorbinil is 0.07 uM)More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:In vitro inhibition of Aldose reductase (AR) from rat lens (RL)More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of human placental aldose reductase (HPAR) activity with glyceraldehyde as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMpH: 7.0 T: 2°CAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Inhibitory activity against bovine lens aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:In vitro inhibitory activity against Aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Inhibitory concentration against aldose reductase obtained from rat lensMore data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibitory activity against aldose reductase in rat lensMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibitory activity against bovine lens aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Inhibition of aldose reductase from rat lens. Value ranges from 0.07 - 1.2More data for this Ligand-Target Pair
Affinity DataIC50: 249nMAssay Description:Inhibition of aldose reductase in rat lensesMore data for this Ligand-Target Pair
Affinity DataIC50: 249nMAssay Description:Inhibition of aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of rat lens ALR2More data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of aldose reductase in Fischer-344 rat lens homogenate by spectrometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:In vitro inhibitory activity of compound against rat lens aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lensMore data for this Ligand-Target Pair
Affinity DataIC50: 280nMAssay Description:Inhibitory activity measured against rat lens aldose reductase using 3-pyridinecarboxaldehyde as substrateChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 430nMAssay Description:Inhibition of rat lenses ALR2 using DL-glyceraldehyde as substrate preincubated for 10 mins followed by substrate addition measured for 4 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:In vitro inhibitory activity against aldose reductase (ALR2) from rat lens extraction.More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibitory activity of the compound was determined against human placental aldose reductase (HPAR) with glyceraldehyde as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:In vitro inhibitory activity towards human placenta aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:In vitro inhibitory activity against aldose reductase (ALR2) from rat lens extraction.More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1 [L301M](Homo sapiens (Human))
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire
Affinity DataIC50: 500nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
Affinity DataIC50: 550nMAssay Description:Inhibition of N-terminal 6His-tagged human aldose reductase expressed in Escherichia coli BL21(DE3) mediated NADPH linked pyridine-3-aldehyde reducti...More data for this Ligand-Target Pair
Affinity DataIC50: 620nMAssay Description:Inhibition of Albino rat eye lens ALR2 assessed as NADPH oxidation by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 650nMAssay Description:Inhibitory concentration to aldose reductase (ALR-2) obtained from rat lensMore data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:Inhibitory activity of the compound against human placental aldose reductase in Orange A column at day 8More data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:Tested for in vitro inhibition activity against rat Aldose reductase (AR)More data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:Inhibitory concentration against rat ALR2 aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 910nMAssay Description:Inhibition of human recombinant aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 919nMAssay Description:Inhibitory Activity against Human recombinant Aldose Reductase (wild type)More data for this Ligand-Target Pair
Affinity DataIC50: 990nMAssay Description:In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney (RK)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against rat lens aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:In vitro % decrease of aldose reductase was measured in isolated partially purified bovine lens preparations at 10e-7 M concentrationMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:In vitro % decrease of aldose reductase was measured in isolated partially purified bovine lens preparations at 10e-6 M concentrationMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
University Of California San Francisco
Curated by ChEMBL
University Of California San Francisco
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of aldose reductase from pig lensesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.41E+3nMAssay Description:Inhibition of bovine lens ALR2 assessed as reduction of D,L-glyceraldehyde by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 1.41E+3nMAssay Description:Inhibition of bovine aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of bovine lens aldose reductase with DL-glyceraldehyde as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 1.56E+3nMAssay Description:The compound was tested for Inhibitory effect against Aldose reductase 1 in bovine kidneysMore data for this Ligand-Target Pair
Affinity DataIC50: 1.85E+3nMAssay Description:Inhibition of Aldose reductase 2 of bovine lensMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of bovine lens ALR2More data for this Ligand-Target Pair
