Affinity Data by PDB ID

PDB code 2WI7

Found 1 hit Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
HSP90 and hnRNPA2/B1 (196/213 = 92%)^† (Homo sapiens (Human))	BDBM33237 (thieno[2,3-d]pyrimidine, 34d) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	Purchase DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	58	n/a	n/a	n/a	n/a	7.4	23
Vernalis (R&D) Ltd					Assay Description The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...				J Med Chem 52: 4794-809 (2009) Article DOI: 10.1021/jm900357y BindingDB Entry DOI: 10.7270/Q2445JVZ
Vernalis (R&D) Ltd					More data for this Ligand-Target Pair				3D Structure (crystal)

_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output