BindingDB PrimarySearch

Found 11 Enz. Inhib. hit(s) for PDB: 2X38

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Universit£

Curated by ChEMBL

BDBM50323726(2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tol...)

Ki: 12.6nMAssay Description:Inhibition of human recombinant full length N-terminal His6-tagged PI3K p110delta/p85alpha expressed in baculovirus infected Sf9 insect cells using P...More data for this Ligand-Target Pair

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3D Structure (crystal)

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Universit£

Curated by ChEMBL

BDBM50323726(2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tol...)

Ki: 20nMAssay Description:Inhibition of [3H](S)-sulpiride binding in striatal homogenates of rat brainMore data for this Ligand-Target Pair

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3D Structure (crystal)

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
University Of California San Francisco

Curated by ChEMBL

BDBM50323726(2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tol...)

Ki: 20nMAssay Description:Inhibition of p110deltaMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
University Of California San Francisco

Curated by ChEMBL

BDBM50323726(2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tol...)

IC50: 25.1nMAssay Description:Inhibition of PI3Kdelta in human PBMC assessed as reduction in anti-human CD28 antibody stimulated IL-6 secretion levels after 72 hrs by ELISAMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
University Of California San Francisco

Curated by ChEMBL

BDBM50323726(2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tol...)

IC50: 50.1nMAssay Description:Inhibition of PI3Kdelta in human PBMC assessed as reduction in anti-human CD28 antibody stimulated IL-6 secretion levels after 72 hrs by ELISAMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
University Of California San Francisco

Curated by ChEMBL

BDBM50323726(2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tol...)

IC50: 130nMAssay Description:Inhibition of PI3Kdelta in presence of 10 uM ATPMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Universit£

Curated by ChEMBL

BDBM50323726(2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tol...)

IC50: 130nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

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3D Structure (crystal)

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
University Of California San Francisco

Curated by ChEMBL

BDBM50323726(2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tol...)

IC50: 130nMAssay Description:Inhibition of p110deltaMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
University Of California San Francisco

Curated by ChEMBL

BDBM50323726(2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tol...)

IC50: 130nMAssay Description:Inhibition of PI3K-delta (unknown origin) expressed in baculovirus infected Sf9 insect cells after 10 mins in presence of [gamma-32P]ATP by radioliga...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
University Of California San Francisco

Curated by ChEMBL

BDBM50323726(2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tol...)

IC50: 160nMAssay Description:Inhibition of PI3K-delta (unknown origin) by cell free biochemical assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
University Of California San Francisco

Curated by ChEMBL

BDBM50323726(2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tol...)

IC50: 500nMAssay Description:Inhibition of PI3Kdelta in presence of 200 uM ATPMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Filter my 11 hits

Targets 2▿
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 8
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform 3
Publications 6▿
- J Med Chem 60: 4304-4315 (2017) 4
- J Med Chem 55: 8559-81 (2012) 2
- Bioorg Med Chem Lett 28: 1005-1010 (2018) 2
- Nat Chem Biol 6: 117-24 (2010) 1
- ACS Med Chem Lett 8: 118-123 (2017) 1
- Chem Biol 12: 621-37 (2005) 1
Institutions 6▿
- Universit£ 4
- Amgen 2
- India Academy Of Scientific & Innovative Research (Acsir) 2
- Medical Research Council-Laboratory Of Molecular Biology 1
- RhôNe-Poulenc Rorer 1
- University Of California San Francisco 1
Affinity: 13 to 5.0E+2 nM▿
- Ki 3
- IC50 8
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1