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Found 9 Enz. Inhib. hit(s) for PDB: 3D7Z
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataKi:  9nMAssay Description:Inhibition of human recombinant p38alpha-mediated ATF2 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataKi:  10nMAssay Description:Inhibition of human recombinant His-tagged p38alpha-mediated ATF2 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataKi:  12nMAssay Description:Displacement of rhodamine-green labeled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]phenyl...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataKi:  12nMAssay Description:Displacement of rhodamine-green labelled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]pheny...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataKi:  12.6nMAssay Description:Inhibition of GST-tagged p38alpha by fluorescence polarization methodMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataIC50:  18nMAssay Description:Inhibition of p38alpha phosphorylation in IL1alpha-stimulated HLF cellsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataIC50:  75nMAssay Description:Displacement of rhodamine-green labelled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]pheny...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataIC50:  200nMAssay Description:Inhibition of p38alpha-dependent TNFalpha production in human PBMC preincubated for 1 hr before LPS challenge by ELISAMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataIC50:  1.58E+3nMAssay Description:Inhibition of p38alpha-dependent TNFalpha production in human whole blood preincubated for 1 hr before LPS challenge by ELISAMore data for this Ligand-Target Pair