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Found 5 Enz. Inhib. hit(s) for PDB: 3PBB
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

LigandPNGBDBM7918(1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)pro...)
Affinity DataKi:  60nMAssay Description:QC activity was evaluated fluorometrically using Gln-AMC as substrate, and pyroglutamyl peptidase as the auxiliary enzyme. After conversion of Gln-AM...More data for this Ligand-Target Pair
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

LigandPNGBDBM7918(1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)pro...)
Affinity DataKi:  60nMAssay Description:Inhibition of human glutaminyl cyclase expressed in Pichia pastoris by pGAP coupled enzyme assayMore data for this Ligand-Target Pair
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

LigandPNGBDBM7918(1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)pro...)
Affinity DataKi:  95nM ΔG°:  -40.1kJ/molepH: 8.0 T: 2°CAssay Description:The testing for the inhibition activities of imidazole derivatives and cacodylate on gQC and sQC was evaluated at 25 C using the fluorescent substrat...More data for this Ligand-Target Pair
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

LigandPNGBDBM7918(1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)pro...)
Affinity DataKi:  1.82E+3nM ΔG°:  -32.8kJ/molepH: 8.0 T: 2°CAssay Description:The testing for the inhibition activities of imidazole derivatives and cacodylate on gQC and sQC was evaluated at 25 C using the fluorescent substrat...More data for this Ligand-Target Pair
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

LigandPNGBDBM7918(1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)pro...)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of human recombinant glutaminyl cyclase expressed in Escherichia coli using H-Gln-Gln-H substrate measured for 15 mins by spectrophotometr...More data for this Ligand-Target Pair