BindingDB PrimarySearch

Found 3 Enz. Inhib. hit(s) for PDB: 3QC4

3-phosphoinositide-dependent protein kinase 1 [51-360](Homo sapiens (Human))
Sunesis Pharmaceuticals

US Patent

BDBM50361645(CHEMBL1234429 | US9873693, Compound 144)

IC50: <500nMAssay Description:A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...More data for this Ligand-Target Pair

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3D Structure (crystal)

3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Merck Research Laboratories

BDBM92406(PDK1 inhibitor, 7)

EC50: 1nMAssay Description:Enzyme potency (PDK1 EC50)was determined using recombinant, purified full-length human PDK1 enzyme and AKT-Thr-308-tide as substrate.More data for this Ligand-Target Pair

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3D Structure (crystal)

3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Merck Research Laboratories

BDBM50361645(CHEMBL1234429 | US9873693, Compound 144)

EC50: 1nMAssay Description:Inhibition of PDK1-mediated AKT1 phosphorylation at T308 in human H460 cells after 2 hrs by ELISAMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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PDB

3D Structure (crystal)