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Found 5 Enz. Inhib. hit(s) for PDB: 3W3M
TargetToll-like receptor 8(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50241029(1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quino...)
Affinity DataEC50:  9.60E+3nMAssay Description:For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells, respectively, (Invivogen, San Diego, Calif., USA) transfected with a SEAP repo...More data for this Ligand-Target Pair
TargetToll-like receptor 8(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50241029(1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quino...)
Affinity DataEC50:  4.00E+3nMAssay Description:Agonist activity at human TLR8 expressed in HEK293 cells incubated for 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetToll-like receptor 8(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50241029(1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quino...)
Affinity DataEC50:  4.50E+3nMAssay Description:Agonist activity at human TLR-8 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assayMore data for this Ligand-Target Pair
TargetToll-like receptor 8(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50241029(1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quino...)
Affinity DataEC50:  6.13E+3nMAssay Description:Agonist activity at human TLR8 expressed in HEK cells after 8 to 12 hrs by NFkappaB/SEAP reporter gene assayMore data for this Ligand-Target Pair
TargetToll-like receptor 8(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50241029(1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quino...)
Affinity DataEC50:  6.40E+3nMAssay Description:Agonist activity at human TLR8 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene as...More data for this Ligand-Target Pair