Compile Data Set for Download or QSAR
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Found 4 Enz. Inhib. hit(s) for PDB: 4QYH
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50035709(CHEMBL3359895)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of recombinant ChK1 (unknown origin) using AKT substrate by AlphaScreen assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50035709(CHEMBL3359895)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human recombinant Chk1 using biotinylated AKT substrate after 30 mins by Alphascreen biochemical assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50035709(CHEMBL3359895)
Affinity DataIC50:  98nMAssay Description:Inhibition of ChK1 in human HT-29 cells assessed as phospho-histone H3 by Isobologram assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50035709(CHEMBL3359895)
Affinity DataEC50:  98nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as phosphorylation of histone H3 after 24 hrs by checkpoint abrogation cellular assayMore data for this Ligand-Target Pair