Found 10 Enz. Inhib. hit(s) for PDB: 4TVJ TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
US Patent
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
US Patent
Affinity DataIC50: 0.450nMAssay Description:In order to test the selectivity of substituents on piperazinotriazole ring within the PARP family, the selectivity of compound S3 and positive compo...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 1nMAssay Description:A FlashPlate scintillation proximity assay has been used to identify inhibitors of PARP-2. PARP-2 protein (recombinant) was bound down by a PARP-2 sp...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
US Patent
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
US Patent
Affinity DataIC50: 1.70nMAssay Description:Inhibition of recombinant human PARP-2 expressed in Escherichia coli BL21 (DE3) using sheared DNA as substrate in presence of biotinylated NAD after ...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
US Patent
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
US Patent
Affinity DataIC50: 2.80nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged PARP2 (2 to 583 residues) expressed in baculovirus infected Sf9 cells using biotinylated substr...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
US Patent
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
US Patent
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human PARP2 using histone as substrate after 1.5 hr in presence of NAD+ by ELISAMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
US Patent
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
US Patent
Affinity DataIC50: 3nMAssay Description:Inhibition of human PARP2 (2 to 583 residues) expressed in Baculovirus infected Sf9 insect cells using activated DNA as substrate after 1 hr by strep...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
US Patent
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
US Patent
Affinity DataIC50: 12nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP2 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
US Patent
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
US Patent
Affinity DataIC50: 12nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP2 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
US Patent
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
US Patent
Affinity DataIC50: 251nMAssay Description:Inhibition of recombinant human His6-tagged PARP2 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins foll...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
US Patent
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
US Patent
Affinity DataKd: 0.280nMAssay Description:Binding affinity to recombinant human HisGST-tagged PARP-2 catalytic domain by surface plasmon resonance analysisMore data for this Ligand-Target Pair
