Found 63 Enz. Inhib. hit(s) for PDB: 4XEY TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataIC50: 0.138nMpH: 7.5 T: 2°CAssay Description:ABL activity assays were performed in 384-well plate using the FRET-based Z'-Lyteassay system and Tyr-2 peptide substrate according to the manufa...More data for this Ligand-Target Pair
3D Structure (crystal)TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataIC50: <0.200nMpH: 7.4 T: 2°CAssay Description:Inhibition of wild-type Abl and Abl T315I kinase activity was measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FRET...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataIC50: 0.260nMAssay Description:Inhibition of human recombinant wild type ABL1 expressed in insect cells after 30 mins by FRET assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataIC50: <0.5nMAssay Description:Inhibition of human ABL using EAIYAAPFAKKK as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Schering-Plough
Curated by ChEMBL
Schering-Plough
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibition of wild type Bcr-AblMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Schering-Plough
Curated by ChEMBL
Schering-Plough
Curated by ChEMBL
Affinity DataIC50: <1nMAssay Description:Inhibition of Bcr-Abl kinaseMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Schering-Plough
Curated by ChEMBL
Schering-Plough
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of wild type Bcr-Abl (unknown origin) using Tyr2 peptide substrate after 2 hrs by FRET-based Z'-lyte assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataIC50: 4nMAssay Description:Inhibition of wild type recombinant human Abl using abtide as substrate by [gamma-32P]ATP based assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataIC50: 4.20nMAssay Description:Inhibition of Abl kinaseMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Schering-Plough
Curated by ChEMBL
Schering-Plough
Curated by ChEMBL
Affinity DataIC50: 7.60nMAssay Description:Inhibition constant against Adenosine A2a receptorMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataIC50: <10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataIC50: <10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant Abl kinaseMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Schering-Plough
Curated by ChEMBL
Schering-Plough
Curated by ChEMBL
Affinity DataIC50: >15nMAssay Description:Inhibition of human BCR/ABL V299L mutantMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Schering-Plough
Curated by ChEMBL
Schering-Plough
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of BRC/ABL1 (unknown origin) after 40 mins by ADP-Glo assayMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Schering-Plough
Curated by ChEMBL
Schering-Plough
Curated by ChEMBL
Affinity DataIC50: 220nMAssay Description:Inhibition constant against Adenosine A2a receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 700nMpH: 7.4 T: 2°CAssay Description:Inhibition of wild-type Abl and Abl T315I kinase activity was measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FRET...More data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Schering-Plough
Curated by ChEMBL
Schering-Plough
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Bcr-Abl T315I mutant (unknown origin) using Tyr2 peptide substrate after 2 hrs by FRET-based Z'-lyte assayMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMpH: 7.4 T: 2°CAssay Description:Inhibition of wild-type Abl and Abl T315I kinase activity was measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FRET...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataKd: 0.0460nMAssay Description:Binding constant for ABL1(H396P)-phosphorylated kinase domainMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataKd: 0.0640nMAssay Description:Binding constant for ABL1(Q252H)-phosphorylated kinase domainMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataKd: 0.0410nMAssay Description:Binding constant for ABL1(F317I)-phosphorylated kinase domainMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataKd: 0.100nMAssay Description:Binding constant for ABL1(F317I)-nonphosphorylated kinase domainMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataKd: 0.0320nMAssay Description:Binding constant for ABL1(F317L)-nonphosphorylated kinase domainMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataKd: 0.0580nMAssay Description:Binding constant for ABL1(Y253F)-phosphorylated kinase domainMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataKd: 120nMAssay Description:Binding constant for ABL1(T315I)-phosphorylated kinase domainMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataKd: 0.0290nMAssay Description:Binding constant for ABL1-nonphosphorylated kinase domainMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataKd: 0.0470nMAssay Description:Binding constant for ABL1(E255K)-phosphorylated kinase domainMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataKd: 890nMAssay Description:Binding constant for ABL1(T315I)-nonphosphorylated kinase domainMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataKd: 0.0160nMAssay Description:Binding constant for ABL1(M351T)-phosphorylated kinase domainMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataKd: 0.0190nMAssay Description:Binding constant for ABL1(F317L)-phosphorylated kinase domainMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataKd: 590nMAssay Description:Binding constant for ABL1(T315I) kinase domainMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataKd: 2.10nMAssay Description:Binding constant for ABL1(E255K) kinase domainMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataKd: 1.10nMAssay Description:Binding constant for ABL1(Q252H) kinase domainMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataKd: 0.960nMAssay Description:Binding constant for ABL1(Y253F) kinase domainMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataKd: 0.720nMAssay Description:Binding constant for ABL1(M351T) kinase domainMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataKd: 0.530nMAssay Description:Binding constant for ABL1 kinase domainMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Schering-Plough
Curated by ChEMBL
Schering-Plough
Curated by ChEMBL
Affinity DataEC50: 0.0400nMAssay Description:Inhibition of human wild type BCR-ABL expressed in mouse BAF3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assayMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Schering-Plough
Curated by ChEMBL
Schering-Plough
Curated by ChEMBL
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of human BCR-ABL T315I mutant expressed in mouse BAF3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataKd: 0.0250nMAssay Description:Binding constant for ABL1(H396P)-nonphosphorylated kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.170nMAssay Description:Binding constant for ABL2 kinase domainMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataKd: 1.20nMAssay Description:Binding constant for ABL1(T315I) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.170nMAssay Description:Binding constant for ABL2 kinase domainMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataKd: 0.0460nMAssay Description:Binding constant for ABL1-phosphorylated kinase domainMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataKd: 0.0370nMAssay Description:Binding constant for ABL1(Q252H)-nonphosphorylated kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.0300nMAssay Description:Inhibitor selectivity profiles were obtained through Luceome Biotechnologies (Tuscon, AZ). Each inhibitor was screened at 0.5 μM against a panel...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataKd: 0.960nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1 [1-999,Q252H](Homo sapiens (Human))
Ambit Biosciences
Curated by PubChem BioAssay
Ambit Biosciences
Curated by PubChem BioAssay
Affinity DataKd: 1.10E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataKd: 0.720nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataKd: 1.20nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
