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Found 3 Enz. Inhib. hit(s) for PDB: 4XV1
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM317744(US11337976, Compound P-0240 | US20230277534, Compo...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of N-terminal His-tagged BRAF V600E mutant (unknown origin) expressed in baculovirus infected insect cells co-expressing CDC37 using bioti...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM317744(US11337976, Compound P-0240 | US20230277534, Compo...)
Affinity DataIC50:  16nMAssay Description:Inhibition of BRAF V600E mutant in human A375 cells assessed as reduction in ERK phosphorylation by AlphaScreen assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317744(US11337976, Compound P-0240 | US20230277534, Compo...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair