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Found 3 Enz. Inhib. hit(s) for PDB: 5KVT
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  0.600nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  1nMAssay Description:Inhibition of TRKA (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human TEL (336 residues) fused-TRKA (440 to 796 residues) (unknown origin) expressed in mouse BAF3 cells assessed as cell growth inhibi...More data for this Ligand-Target Pair