Compile Data Set for Download or QSAR
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Found 3 Enz. Inhib. hit(s) for PDB: 6AAK
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50463838(CHEMBL4238926)
Affinity DataIC50:  0.430nMAssay Description:Inhibition of recombinant human N-terminal His-tagged JAK3 catalytic domain (795 to 1124 residues) expressed in baculovirus expression system using B...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50463838(CHEMBL4238926)
Affinity DataIC50:  0.710nMAssay Description:Inhibition of recombinant human N-terminal His-tagged JAK3 catalytic domain (795 to 1124 residues) expressed in baculovirus expression system using B...More data for this Ligand-Target Pair
TargetJAK3/JAK1(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50463838(CHEMBL4238926)
Affinity DataIC50:  18nMAssay Description:Inhibition of JAK1/JAK3 in human PBMC assessed as reduction in IL-2-induced T cell proliferation after 3 days by alamar blue assayMore data for this Ligand-Target Pair