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Found 3 Enz. Inhib. hit(s) for PDB: 6HMM
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
University Of Manchester

LigandPNGBDBM205478(PDD00013907 (1))
Affinity DataIC50: >6.00E+4nMpH: 7.4Assay Description:Briefly, PARG in vitro assays were conducted in a total volume of 15 μL in a standard 384-well format. A total of 5 μL of human full length...More data for this Ligand-Target Pair
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
University Of Manchester

LigandPNGBDBM205478(PDD00013907 (1))
Affinity DataEC50:  8.10E+4nMAssay Description:Inhibition of human full length PARG using Bt-NAD ribosylated PARP1 substrate after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
University Of Manchester

LigandPNGBDBM205478(PDD00013907 (1))
Affinity DataEC50:  3.00E+4nMAssay Description:Inhibition of PARG in human HeLa cells assessed as induction of MMS-induced PAR chains preincubated for 1 hr followed by MMS addition and measured af...More data for this Ligand-Target Pair