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Found 27 Enz. Inhib. hit(s) with all data for entry = 50009466
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50072244((Z)-4-(3,4-Difluoro-phenyl)-2-hydroxy-4-oxo-but-2-...)
Affinity DataIC50:  120nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50083948(4-(3-Chloro-4-fluoro-phenyl)-2-hydroxy-4-oxo-but-2...)
Affinity DataIC50:  270nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50083940(4-(3-Chloro-phenyl)-2-hydroxy-4-oxo-but-2-enoic ac...)
Affinity DataIC50:  320nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50083931(4-(3-Fluoro-phenyl)-2-hydroxy-4-oxo-but-2-enoic ac...)
Affinity DataIC50:  580nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50083933(2-Amino-4-(3-chloro-4-fluoro-phenyl)-4-oxo-but-2-e...)
Affinity DataIC50:  820nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50083935(2-Amino-4-(3,4-dichloro-phenyl)-4-oxo-but-2-enoic ...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50072260((Z)-4-(3,4-Dichloro-phenyl)-2-hydroxy-4-oxo-but-2-...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50083945(2-Amino-4-(3,4-difluoro-phenyl)-4-oxo-but-2-enoic ...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50083936(4-(3-Fluoro-phenyl)-2-hydroxy-4-oxo-but-2-enoic ac...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50083944(2-Amino-4-oxo-4-phenyl-but-2-enoic acid methyl est...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50083953((Z)-4-(3-Bromo-phenyl)-2-hydroxy-4-oxo-but-2-enoic...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50083954(4-(3,4-Dichloro-phenyl)-2-hydroxy-4-oxo-but-2-enoi...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50083949(4-(3-Chloro-phenyl)-2-hydroxy-4-oxo-but-2-enoic ac...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50083937(4-(4-Bromo-phenyl)-2-hydroxy-4-oxo-but-2-enoic aci...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50083941(4-(4-Chloro-3-nitro-phenyl)-2-hydroxy-4-oxo-but-2-...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50083951(4-(3-Bromo-phenyl)-2-hydroxy-4-oxo-but-2-enoic aci...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50083946(2-Amino-4-(3-chloro-phenyl)-4-oxo-but-2-enoic acid...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50083942(4-(3-Chloro-4-fluoro-phenyl)-2-hydroxy-4-oxo-but-2...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50083934(4-(4-Chloro-phenyl)-2-hydroxy-4-oxo-but-2-enoic ac...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50083952(4-(3,4-Difluoro-phenyl)-2-hydroxy-4-oxo-but-2-enoi...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50083939(2-Amino-4-(3,4-difluoro-phenyl)-4-oxo-but-2-enoic ...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50083950((S)-(+)-2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric a...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50083947(4-(4-Chloro-3-methyl-phenyl)-2-hydroxy-4-oxo-but-2...)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50083938(2-Amino-4-(3-chloro-phenyl)-4-oxo-but-2-enoic acid...)
Affinity DataIC50:  7.90E+3nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50061907((+/-)-2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric aci...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50083943(4-(2,3-Difluoro-phenyl)-2-hydroxy-4-oxo-but-2-enoi...)
Affinity DataIC50:  8.10E+3nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50083932(4-(4-Chloro-3-nitro-phenyl)-2-hydroxy-4-oxo-but-2-...)
Affinity DataIC50:  1.12E+4nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed