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Found 26 Enz. Inhib. hit(s) with all data for entry = 50035106
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50085506((1R,3S)-5-Methylene-3-p-tolyl-7-aza-tricyclo[5.3.0...)
Affinity DataIC50:  2.20nMAssay Description:The compound was tested for inhibition of [3H]norepinephrine uptake in HEK cells by expressing cDNA for human norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50085504((1R,3S,5R)-5-Phenyl-3-p-tolyl-7-aza-tricyclo[5.3.0...)
Affinity DataIC50:  7.90nMAssay Description:The compound was tested for inhibition of [3H]-5-hydroxy tryptamine uptake in HEK cells by expressing cDNA for human tryptamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50085504((1R,3S,5R)-5-Phenyl-3-p-tolyl-7-aza-tricyclo[5.3.0...)
Affinity DataIC50:  11nMAssay Description:The compound was tested for inhibition of [3H]norepinephrine uptake in HEK cells by expressing cDNA for human norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50085505((1R,3S,5R)-5-(4-Chloro-phenyl)-3-p-tolyl-7-aza-tri...)
Affinity DataIC50:  13nMAssay Description:The compound was tested for inhibition of [3H]-5-hydroxy tryptamine uptake in HEK cells by expressing cDNA for human tryptamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50085503((1R,3S,5S)-5-Propyl-3-p-tolyl-7-aza-tricyclo[5.3.0...)
Affinity DataIC50:  18nMAssay Description:The compound was tested for inhibition of [3H]norepinephrine uptake in HEK cells by expressing cDNA for human norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50085505((1R,3S,5R)-5-(4-Chloro-phenyl)-3-p-tolyl-7-aza-tri...)
Affinity DataIC50:  23nMAssay Description:The compound was tested for inhibition of [3H]norepinephrine uptake in HEK cells by expressing cDNA for human norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50085506((1R,3S)-5-Methylene-3-p-tolyl-7-aza-tricyclo[5.3.0...)
Affinity DataIC50:  33nMAssay Description:The compound was tested for inhibition of [3H]-5-hydroxy tryptamine uptake in HEK cells by expressing cDNA for human tryptamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50085503((1R,3S,5S)-5-Propyl-3-p-tolyl-7-aza-tricyclo[5.3.0...)
Affinity DataIC50:  41nMAssay Description:The compound was tested for inhibition of [3H]-5-hydroxy tryptamine uptake in HEK cells by expressing cDNA for human tryptamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50085505((1R,3S,5R)-5-(4-Chloro-phenyl)-3-p-tolyl-7-aza-tri...)
Affinity DataIC50:  44nMAssay Description:Inhibition of [3H]dopamine uptake in HEK cells expressing human Dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50085506((1R,3S)-5-Methylene-3-p-tolyl-7-aza-tricyclo[5.3.0...)
Affinity DataIC50:  67nMAssay Description:Inhibition of [3H]dopamine uptake in HEK cells expressing human Dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50085507((1R,3S)-3-p-Tolyl-7-aza-tricyclo[5.3.0.0*4,8*]deca...)
Affinity DataIC50:  68nMAssay Description:The compound was tested for inhibition of [3H]-5-hydroxy tryptamine uptake in HEK cells by expressing cDNA for human tryptamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50085504((1R,3S,5R)-5-Phenyl-3-p-tolyl-7-aza-tricyclo[5.3.0...)
Affinity DataIC50:  89nMAssay Description:Inhibition of [3H]dopamine uptake in HEK cells expressing human Dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50085502((4S,6S)-3-Butyl-4-p-tolyl-1-aza-tricyclo[4.4.0.0*2...)
Affinity DataIC50:  109nMAssay Description:The compound was tested for inhibition of [3H]norepinephrine uptake in HEK cells by expressing cDNA for human norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50085507((1R,3S)-3-p-Tolyl-7-aza-tricyclo[5.3.0.0*4,8*]deca...)
Affinity DataIC50:  110nMAssay Description:The compound was tested for inhibition of [3H]norepinephrine uptake in HEK cells by expressing cDNA for human norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50085508((1R,3S,5S)-5-Methyl-3-p-tolyl-7-aza-tricyclo[5.3.0...)
Affinity DataIC50:  147nMAssay Description:The compound was tested for inhibition of [3H]-5-hydroxy tryptamine uptake in HEK cells by expressing cDNA for human tryptamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM22418(Cocaine | Cocaine (-) | methyl (1R,2R,3S,5S)-3-(be...)
Affinity DataIC50:  186nMAssay Description:The compound was tested for inhibition of [3H]norepinephrine uptake in HEK cells by expressing cDNA for human norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50085501((1R,3S)-3-(4-Fluoro-phenyl)-7-aza-tricyclo[5.3.0.0...)
Affinity DataIC50:  251nMAssay Description:The compound was tested for inhibition of [3H]-5-hydroxy tryptamine uptake in HEK cells by expressing cDNA for human tryptamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50085508((1R,3S,5S)-5-Methyl-3-p-tolyl-7-aza-tricyclo[5.3.0...)
Affinity DataIC50:  296nMAssay Description:The compound was tested for inhibition of [3H]norepinephrine uptake in HEK cells by expressing cDNA for human norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM22418(Cocaine | Cocaine (-) | methyl (1R,2R,3S,5S)-3-(be...)
Affinity DataIC50:  301nMAssay Description:Inhibition of [3H]dopamine uptake in HEK cells expressing human Dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50085503((1R,3S,5S)-5-Propyl-3-p-tolyl-7-aza-tricyclo[5.3.0...)
Affinity DataIC50:  373nMAssay Description:Inhibition of [3H]dopamine uptake in HEK cells expressing human Dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50085508((1R,3S,5S)-5-Methyl-3-p-tolyl-7-aza-tricyclo[5.3.0...)
Affinity DataIC50:  390nMAssay Description:Inhibition of [3H]dopamine uptake in HEK cells expressing human Dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM22418(Cocaine | Cocaine (-) | methyl (1R,2R,3S,5S)-3-(be...)
Affinity DataIC50:  413nMAssay Description:The compound was tested for inhibition of [3H]-5-hydroxy tryptamine uptake in HEK cells by expressing cDNA for human tryptamine transporterMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50085507((1R,3S)-3-p-Tolyl-7-aza-tricyclo[5.3.0.0*4,8*]deca...)
Affinity DataIC50:  538nMAssay Description:Inhibition of [3H]dopamine uptake in HEK cells expressing human Dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50085502((4S,6S)-3-Butyl-4-p-tolyl-1-aza-tricyclo[4.4.0.0*2...)
Affinity DataIC50:  570nMAssay Description:Inhibition of [3H]dopamine uptake in HEK cells expressing human Dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50085501((1R,3S)-3-(4-Fluoro-phenyl)-7-aza-tricyclo[5.3.0.0...)
Affinity DataIC50:  620nMAssay Description:The compound was tested for inhibition of [3H]norepinephrine uptake in HEK cells by expressing cDNA for human norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50085501((1R,3S)-3-(4-Fluoro-phenyl)-7-aza-tricyclo[5.3.0.0...)
Affinity DataIC50:  3.32E+3nMAssay Description:Inhibition of [3H]dopamine uptake in HEK cells expressing human Dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed