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PubMed code 11063624

Compile data set for download or QSAR
Found 95 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093652
PNG
(2-Methyl-6-pentyl-4-piperidin-1-yl-5H-pyrrolo[3,2-...)
Show SMILES CCCCCc1cc2nc(C)nc(N3CCCCC3)c2[nH]1
Show InChI InChI=1S/C17H26N4/c1-3-4-6-9-14-12-15-16(20-14)17(19-13(2)18-15)21-10-7-5-8-11-21/h12,20H,3-11H2,1-2H3
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n/an/a 0.200n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093646
PNG
(6-Benzofuran-2-yl-2-methyl-4-piperidin-1-yl-5H-pyr...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1cc2ccccc2o1
Show InChI InChI=1S/C20H20N4O/c1-13-21-16-12-15(18-11-14-7-3-4-8-17(14)25-18)23-19(16)20(22-13)24-9-5-2-6-10-24/h3-4,7-8,11-12,23H,2,5-6,9-10H2,1H3
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n/an/a 0.300n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093664
PNG
(6-(4-Fluoro-phenyl)-2-methyl-4-piperidin-1-yl-5H-p...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C18H19FN4/c1-12-20-16-11-15(13-5-7-14(19)8-6-13)22-17(16)18(21-12)23-9-3-2-4-10-23/h5-8,11,22H,2-4,9-10H2,1H3
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n/an/a 0.300n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093696
PNG
(6-(3-Fluoro-phenyl)-2-methyl-4-piperidin-1-yl-5H-p...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1cccc(F)c1
Show InChI InChI=1S/C18H19FN4/c1-12-20-16-11-15(13-6-5-7-14(19)10-13)22-17(16)18(21-12)23-8-3-2-4-9-23/h5-7,10-11,22H,2-4,8-9H2,1H3
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n/an/a 0.300n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093675
PNG
(6-(3,5-Difluoro-phenyl)-2-methyl-4-piperidin-1-yl-...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C18H18F2N4/c1-11-21-16-10-15(12-7-13(19)9-14(20)8-12)23-17(16)18(22-11)24-5-3-2-4-6-24/h7-10,23H,2-6H2,1H3
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n/an/a 0.400n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093691
PNG
(4-(3,6-Dihydro-2H-pyridin-1-yl)-2-methyl-6-phenyl-...)
Show SMILES Cc1nc(N2CCC=CC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C18H18N4/c1-13-19-16-12-15(14-8-4-2-5-9-14)21-17(16)18(20-13)22-10-6-3-7-11-22/h2-6,8-9,12,21H,7,10-11H2,1H3
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n/an/a 0.400n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093697
PNG
(2-Methyl-4-piperidin-1-yl-6-p-tolyl-5H-pyrrolo[3,2...)
Show SMILES Cc1ccc(cc1)-c1cc2nc(C)nc(N3CCCCC3)c2[nH]1
Show InChI InChI=1S/C19H22N4/c1-13-6-8-15(9-7-13)16-12-17-18(22-16)19(21-14(2)20-17)23-10-4-3-5-11-23/h6-9,12,22H,3-5,10-11H2,1-2H3
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n/an/a 0.5n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093647
PNG
(2-Methyl-6-(5-methyl-furan-2-yl)-4-piperidin-1-yl-...)
Show SMILES Cc1ccc(o1)-c1cc2nc(C)nc(N3CCCCC3)c2[nH]1
Show InChI InChI=1S/C17H20N4O/c1-11-6-7-15(22-11)13-10-14-16(20-13)17(19-12(2)18-14)21-8-4-3-5-9-21/h6-7,10,20H,3-5,8-9H2,1-2H3
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n/an/a 0.5n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093678
PNG
(2-Methyl-6-phenyl-4-pyrrolidin-1-yl-5H-pyrrolo[3,2...)
Show SMILES Cc1nc(N2CCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C17H18N4/c1-12-18-15-11-14(13-7-3-2-4-8-13)20-16(15)17(19-12)21-9-5-6-10-21/h2-4,7-8,11,20H,5-6,9-10H2,1H3
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n/an/a 0.700n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093673
PNG
(2-Methyl-4-piperidin-1-yl-6-(4-trifluoromethyl-phe...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C19H19F3N4/c1-12-23-16-11-15(13-5-7-14(8-6-13)19(20,21)22)25-17(16)18(24-12)26-9-3-2-4-10-26/h5-8,11,25H,2-4,9-10H2,1H3
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n/an/a 0.700n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093683
PNG
(2-Methyl-6-phenyl-4-piperidin-1-yl-5H-pyrrolo[3,2-...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C18H20N4/c1-13-19-16-12-15(14-8-4-2-5-9-14)21-17(16)18(20-13)22-10-6-3-7-11-22/h2,4-5,8-9,12,21H,3,6-7,10-11H2,1H3
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n/an/a 1.10n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093651
PNG
(6-Phenyl-4-piperidin-1-yl-5H-pyrrolo[3,2-d]pyrimid...)
Show SMILES Nc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C17H19N5/c18-17-20-14-11-13(12-7-3-1-4-8-12)19-15(14)16(21-17)22-9-5-2-6-10-22/h1,3-4,7-8,11,19H,2,5-6,9-10H2,(H2,18,20,21)
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n/an/a 1.20n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093692
PNG
(5-Methyl-2-phenyl-7-piperidin-1-yl-1H-pyrrolo[3,2-...)
Show SMILES Cc1cc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C19H21N3/c1-14-12-18(22-10-6-3-7-11-22)19-17(20-14)13-16(21-19)15-8-4-2-5-9-15/h2,4-5,8-9,12-13,21H,3,6-7,10-11H2,1H3
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n/an/a 1.70n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093616
PNG
(4-Azepan-1-yl-2-methyl-6-phenyl-5H-pyrrolo[3,2-d]p...)
Show SMILES Cc1nc(N2CCCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C19H22N4/c1-14-20-17-13-16(15-9-5-4-6-10-15)22-18(17)19(21-14)23-11-7-2-3-8-12-23/h4-6,9-10,13,22H,2-3,7-8,11-12H2,1H3
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n/an/a 1.80n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093640
PNG
(4-(2,5-Dihydro-pyrrol-1-yl)-2-methyl-6-phenyl-5H-p...)
Show SMILES Cc1nc(N2CC=CC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C17H16N4/c1-12-18-15-11-14(13-7-3-2-4-8-13)20-16(15)17(19-12)21-9-5-6-10-21/h2-8,11,20H,9-10H2,1H3
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n/an/a 2.20n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093672
PNG
(2-Methyl-4-(2-methyl-piperidin-1-yl)-6-phenyl-5H-p...)
Show SMILES CC1CCCCN1c1nc(C)nc2cc([nH]c12)-c1ccccc1
Show InChI InChI=1S/C19H22N4/c1-13-8-6-7-11-23(13)19-18-17(20-14(2)21-19)12-16(22-18)15-9-4-3-5-10-15/h3-5,9-10,12-13,22H,6-8,11H2,1-2H3
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n/an/a 3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093624
PNG
(2-Methyl-6-phenethyl-4-piperidin-1-yl-5H-pyrrolo[3...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(CCc3ccccc3)cc2n1
Show InChI InChI=1S/C20H24N4/c1-15-21-18-14-17(11-10-16-8-4-2-5-9-16)23-19(18)20(22-15)24-12-6-3-7-13-24/h2,4-5,8-9,14,23H,3,6-7,10-13H2,1H3
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n/an/a 5.30n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093632
PNG
(6-Cyclohexylmethyl-2-methyl-4-piperidin-1-yl-5H-py...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(CC3CCCCC3)cc2n1
Show InChI InChI=1S/C19H28N4/c1-14-20-17-13-16(12-15-8-4-2-5-9-15)22-18(17)19(21-14)23-10-6-3-7-11-23/h13,15,22H,2-12H2,1H3
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n/an/a 8.5n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093666
PNG
(6-Butyl-2-methyl-4-piperidin-1-yl-5H-pyrrolo[3,2-d...)
Show SMILES CCCCc1cc2nc(C)nc(N3CCCCC3)c2[nH]1
Show InChI InChI=1S/C16H24N4/c1-3-4-8-13-11-14-15(19-13)16(18-12(2)17-14)20-9-6-5-7-10-20/h11,19H,3-10H2,1-2H3
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n/an/a 10n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093693
PNG
(6-Cyclohexyl-2-methyl-4-piperidin-1-yl-5H-pyrrolo[...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)C1CCCCC1
Show InChI InChI=1S/C18H26N4/c1-13-19-16-12-15(14-8-4-2-5-9-14)21-17(16)18(20-13)22-10-6-3-7-11-22/h12,14,21H,2-11H2,1H3
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n/an/a 11n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093704
PNG
(4-(2,6-Dimethyl-piperidin-1-yl)-2-methyl-6-phenyl-...)
Show SMILES CC1CCCC(C)N1c1nc(C)nc2cc([nH]c12)-c1ccccc1
Show InChI InChI=1S/C20H24N4/c1-13-8-7-9-14(2)24(13)20-19-18(21-15(3)22-20)12-17(23-19)16-10-5-4-6-11-16/h4-6,10-14,23H,7-9H2,1-3H3
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n/an/a 17n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093633
PNG
(2-Methyl-6-phenoxymethyl-4-piperidin-1-yl-5H-pyrro...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(COc3ccccc3)cc2n1
Show InChI InChI=1S/C19H22N4O/c1-14-20-17-12-15(13-24-16-8-4-2-5-9-16)22-18(17)19(21-14)23-10-6-3-7-11-23/h2,4-5,8-9,12,22H,3,6-7,10-11,13H2,1H3
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n/an/a 18n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093679
PNG
(2-Ethyl-6-phenyl-4-piperidin-1-yl-5H-pyrrolo[3,2-d...)
Show SMILES CCc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C19H22N4/c1-2-17-20-16-13-15(14-9-5-3-6-10-14)21-18(16)19(22-17)23-11-7-4-8-12-23/h3,5-6,9-10,13,21H,2,4,7-8,11-12H2,1H3
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n/an/a 20n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093700
PNG
(6-Phenyl-4-piperidin-1-yl-2-propyl-5H-pyrrolo[3,2-...)
Show SMILES CCCc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C20H24N4/c1-2-9-18-21-17-14-16(15-10-5-3-6-11-15)22-19(17)20(23-18)24-12-7-4-8-13-24/h3,5-6,10-11,14,22H,2,4,7-9,12-13H2,1H3
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n/an/a 28n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093662
PNG
(CHEMBL136650 | Methyl-(6-phenyl-4-piperidin-1-yl-5...)
Show SMILES CNc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C18H21N5/c1-19-18-21-15-12-14(13-8-4-2-5-9-13)20-16(15)17(22-18)23-10-6-3-7-11-23/h2,4-5,8-9,12,20H,3,6-7,10-11H2,1H3,(H,19,21,22)
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n/an/a 29n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093658
PNG
(2-Methyl-6-phenyl-4-piperidin-1-yl-furo[3,2-d]pyri...)
Show SMILES Cc1nc(N2CCCCC2)c2oc(cc2n1)-c1ccccc1
Show InChI InChI=1S/C18H19N3O/c1-13-19-15-12-16(14-8-4-2-5-9-14)22-17(15)18(20-13)21-10-6-3-7-11-21/h2,4-5,8-9,12H,3,6-7,10-11H2,1H3
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n/an/a 30n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093684
PNG
(2-Cyclopropyl-6-phenyl-4-piperidin-1-yl-5H-pyrrolo...)
Show SMILES C1CC1c1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C20H22N4/c1-3-7-14(8-4-1)16-13-17-18(21-16)20(24-11-5-2-6-12-24)23-19(22-17)15-9-10-15/h1,3-4,7-8,13,15,21H,2,5-6,9-12H2
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n/an/a 32n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093614
PNG
(CHEMBL337152 | Diethyl-(2-methyl-6-phenyl-5H-pyrro...)
Show SMILES CCN(CC)c1nc(C)nc2cc([nH]c12)-c1ccccc1
Show InChI InChI=1S/C17H20N4/c1-4-21(5-2)17-16-15(18-12(3)19-17)11-14(20-16)13-9-7-6-8-10-13/h6-11,20H,4-5H2,1-3H3
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n/an/a 36n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093613
PNG
(6-(4-Methoxy-phenyl)-2-methyl-4-piperidin-1-yl-5H-...)
Show SMILES COc1ccc(cc1)-c1cc2nc(C)nc(N3CCCCC3)c2[nH]1
Show InChI InChI=1S/C19H22N4O/c1-13-20-17-12-16(14-6-8-15(24-2)9-7-14)22-18(17)19(21-13)23-10-4-3-5-11-23/h6-9,12,22H,3-5,10-11H2,1-2H3
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n/an/a 41n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093618
PNG
(6-(2-Fluoro-phenyl)-2-methyl-4-piperidin-1-yl-5H-p...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1F
Show InChI InChI=1S/C18H19FN4/c1-12-20-16-11-15(13-7-3-4-8-14(13)19)22-17(16)18(21-12)23-9-5-2-6-10-23/h3-4,7-8,11,22H,2,5-6,9-10H2,1H3
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n/an/a 44n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093674
PNG
(6-Adamantan-1-yl-2-methyl-4-piperidin-1-yl-5H-pyrr...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)C12C[C@H]3C[C@H](C[C@H](C3)C1)C2
Show InChI InChI=1S/C22H30N4/c1-14-23-18-10-19(22-11-15-7-16(12-22)9-17(8-15)13-22)25-20(18)21(24-14)26-5-3-2-4-6-26/h10,15-17,25H,2-9,11-13H2,1H3/t15-,16+,17-,22?
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n/an/a 45n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093657
PNG
(CHEMBL137613 | Furan-2-ylmethyl-methyl-(2-methyl-6...)
Show SMILES CN(Cc1ccco1)c1nc(C)nc2cc([nH]c12)-c1ccccc1
Show InChI InChI=1S/C19H18N4O/c1-13-20-17-11-16(14-7-4-3-5-8-14)22-18(17)19(21-13)23(2)12-15-9-6-10-24-15/h3-11,22H,12H2,1-2H3
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n/an/a 52n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093629
PNG
(2,7-Dimethyl-6-phenyl-4-piperidin-1-yl-5H-pyrrolo[...)
Show SMILES Cc1c([nH]c2c(nc(C)nc12)N1CCCCC1)-c1ccccc1
Show InChI InChI=1S/C19H22N4/c1-13-16(15-9-5-3-6-10-15)22-18-17(13)20-14(2)21-19(18)23-11-7-4-8-12-23/h3,5-6,9-10,22H,4,7-8,11-12H2,1-2H3
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n/an/a 53n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093649
PNG
(4-Azetidin-1-yl-2-methyl-6-phenyl-5H-pyrrolo[3,2-d...)
Show SMILES Cc1nc(N2CCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C16H16N4/c1-11-17-14-10-13(12-6-3-2-4-7-12)19-15(14)16(18-11)20-8-5-9-20/h2-4,6-7,10,19H,5,8-9H2,1H3
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n/an/a 57n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093706
PNG
(2-Methyl-4-piperidin-1-yl-6-propyl-5H-pyrrolo[3,2-...)
Show SMILES CCCc1cc2nc(C)nc(N3CCCCC3)c2[nH]1
Show InChI InChI=1S/C15H22N4/c1-3-7-12-10-13-14(18-12)15(17-11(2)16-13)19-8-5-4-6-9-19/h10,18H,3-9H2,1-2H3
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n/an/a 66n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093667
PNG
(4-(2-Ethyl-piperidin-1-yl)-2-methyl-6-phenyl-5H-py...)
Show SMILES CCC1CCCCN1c1nc(C)nc2cc([nH]c12)-c1ccccc1
Show InChI InChI=1S/C20H24N4/c1-3-16-11-7-8-12-24(16)20-19-18(21-14(2)22-20)13-17(23-19)15-9-5-4-6-10-15/h4-6,9-10,13,16,23H,3,7-8,11-12H2,1-2H3
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n/an/a 74n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093644
PNG
(6-(2,5-Difluoro-phenyl)-2-methyl-4-piperidin-1-yl-...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1cc(F)ccc1F
Show InChI InChI=1S/C18H18F2N4/c1-11-21-16-10-15(13-9-12(19)5-6-14(13)20)23-17(16)18(22-11)24-7-3-2-4-8-24/h5-6,9-10,23H,2-4,7-8H2,1H3
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n/an/a 79n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093639
PNG
(2-Methyl-4-morpholin-4-yl-6-phenyl-5H-pyrrolo[3,2-...)
Show SMILES Cc1nc(N2CCOCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C17H18N4O/c1-12-18-15-11-14(13-5-3-2-4-6-13)20-16(15)17(19-12)21-7-9-22-10-8-21/h2-6,11,20H,7-10H2,1H3
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n/an/a 100n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093702
PNG
(2-Methyl-4-piperidin-1-yl-6-thiophen-2-yl-5H-pyrro...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1cccs1
Show InChI InChI=1S/C16H18N4S/c1-11-17-13-10-12(14-6-5-9-21-14)19-15(13)16(18-11)20-7-3-2-4-8-20/h5-6,9-10,19H,2-4,7-8H2,1H3
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n/an/a 100n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093698
PNG
((6-Phenyl-4-piperidin-1-yl-5H-pyrrolo[3,2-d]pyrimi...)
Show SMILES CCCNc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C20H25N5/c1-2-11-21-20-23-17-14-16(15-9-5-3-6-10-15)22-18(17)19(24-20)25-12-7-4-8-13-25/h3,5-6,9-10,14,22H,2,4,7-8,11-13H2,1H3,(H,21,23,24)
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n/an/a 120n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093659
PNG
(6-Benzo[b]thiophen-2-yl-2-methyl-4-piperidin-1-yl-...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1cc2ccccc2s1
Show InChI InChI=1S/C20H20N4S/c1-13-21-16-12-15(18-11-14-7-3-4-8-17(14)25-18)23-19(16)20(22-13)24-9-5-2-6-10-24/h3-4,7-8,11-12,23H,2,5-6,9-10H2,1H3
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n/an/a 140n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093628
PNG
(6-[2-(4-Methoxy-phenyl)-ethyl]-2-methyl-4-piperidi...)
Show SMILES COc1ccc(CCc2cc3nc(C)nc(N4CCCCC4)c3[nH]2)cc1
Show InChI InChI=1S/C21H26N4O/c1-15-22-19-14-17(9-6-16-7-10-18(26-2)11-8-16)24-20(19)21(23-15)25-12-4-3-5-13-25/h7-8,10-11,14,24H,3-6,9,12-13H2,1-2H3
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n/an/a 150n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093689
PNG
(2-Methyl-4-piperidin-1-yl-6-pyridin-2-yl-5H-pyrrol...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccn1
Show InChI InChI=1S/C17H19N5/c1-12-19-15-11-14(13-7-3-4-8-18-13)21-16(15)17(20-12)22-9-5-2-6-10-22/h3-4,7-8,11,21H,2,5-6,9-10H2,1H3
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n/an/a 150n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093654
PNG
(2,6-Dimethyl-4-piperidin-1-yl-5H-pyrrolo[3,2-d]pyr...)
Show SMILES Cc1cc2nc(C)nc(N3CCCCC3)c2[nH]1
Show InChI InChI=1S/C13H18N4/c1-9-8-11-12(14-9)13(16-10(2)15-11)17-6-4-3-5-7-17/h8,14H,3-7H2,1-2H3
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n/an/a 160n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093653
PNG
(2-Methyl-4-piperidin-1-yl-6-(3-trifluoromethyl-ben...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(Cc3cccc(c3)C(F)(F)F)cc2n1
Show InChI InChI=1S/C20H21F3N4/c1-13-24-17-12-16(11-14-6-5-7-15(10-14)20(21,22)23)26-18(17)19(25-13)27-8-3-2-4-9-27/h5-7,10,12,26H,2-4,8-9,11H2,1H3
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n/an/a 170n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093695
PNG
(4-(3,5-Dimethyl-piperidin-1-yl)-2-methyl-6-phenyl-...)
Show SMILES CC1CC(C)CN(C1)c1nc(C)nc2cc([nH]c12)-c1ccccc1
Show InChI InChI=1S/C20H24N4/c1-13-9-14(2)12-24(11-13)20-19-18(21-15(3)22-20)10-17(23-19)16-7-5-4-6-8-16/h4-8,10,13-14,23H,9,11-12H2,1-3H3
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n/an/a 190n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093623
PNG
(2-(2-Methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-4-...)
Show SMILES Cc1nc(N2CCc3ccccc3C2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C22H20N4/c1-15-23-20-13-19(17-8-3-2-4-9-17)25-21(20)22(24-15)26-12-11-16-7-5-6-10-18(16)14-26/h2-10,13,25H,11-12,14H2,1H3
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n/an/a 220n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093663
PNG
(2-Methyl-6-phenyl-4-piperidin-1-yl-thieno[3,2-d]py...)
Show SMILES Cc1nc(N2CCCCC2)c2sc(cc2n1)-c1ccccc1
Show InChI InChI=1S/C18H19N3S/c1-13-19-15-12-16(14-8-4-2-5-9-14)22-17(15)18(20-13)21-10-6-3-7-11-21/h2,4-5,8-9,12H,3,6-7,10-11H2,1H3
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n/an/a 220n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093641
PNG
(1-(2-Methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-4-...)
Show SMILES Cc1nc(N2CCC(O)CC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C18H20N4O/c1-12-19-16-11-15(13-5-3-2-4-6-13)21-17(16)18(20-12)22-9-7-14(23)8-10-22/h2-6,11,14,21,23H,7-10H2,1H3
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n/an/a 250n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093699
PNG
(CHEMBL138278 | Dimethyl-(6-phenyl-4-piperidin-1-yl...)
Show SMILES CN(C)c1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C19H23N5/c1-23(2)19-21-16-13-15(14-9-5-3-6-10-14)20-17(16)18(22-19)24-11-7-4-8-12-24/h3,5-6,9-10,13,20H,4,7-8,11-12H2,1-2H3
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n/an/a 280n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093650
PNG
(7-Ethyl-2-methyl-6-phenyl-4-piperidin-1-yl-5H-pyrr...)
Show SMILES CCc1c([nH]c2c(nc(C)nc12)N1CCCCC1)-c1ccccc1
Show InChI InChI=1S/C20H24N4/c1-3-16-17(15-10-6-4-7-11-15)23-19-18(16)21-14(2)22-20(19)24-12-8-5-9-13-24/h4,6-7,10-11,23H,3,5,8-9,12-13H2,1-2H3
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n/an/a 330n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093686
PNG
(6-(2,6-Difluoro-phenyl)-2-methyl-4-piperidin-1-yl-...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1c(F)cccc1F
Show InChI InChI=1S/C18H18F2N4/c1-11-21-15-10-14(16-12(19)6-5-7-13(16)20)23-17(15)18(22-11)24-8-3-2-4-9-24/h5-7,10,23H,2-4,8-9H2,1H3
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n/an/a 380n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093615
PNG
(2-Methyl-6,7-diphenyl-4-piperidin-1-yl-5H-pyrrolo[...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(c(-c3ccccc3)c2n1)-c1ccccc1
Show InChI InChI=1S/C24H24N4/c1-17-25-22-20(18-11-5-2-6-12-18)21(19-13-7-3-8-14-19)27-23(22)24(26-17)28-15-9-4-10-16-28/h2-3,5-8,11-14,27H,4,9-10,15-16H2,1H3
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n/an/a 420n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093682
PNG
(2-Isobutyl-6-phenyl-4-piperidin-1-yl-5H-pyrrolo[3,...)
Show SMILES CC(C)Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C21H26N4/c1-15(2)13-19-22-18-14-17(16-9-5-3-6-10-16)23-20(18)21(24-19)25-11-7-4-8-12-25/h3,5-6,9-10,14-15,23H,4,7-8,11-13H2,1-2H3
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n/an/a 460n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093687
PNG
(2-Methyl-8-phenyl-6-piperidin-1-yl-7H-purine | CHE...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(nc2n1)-c1ccccc1
Show InChI InChI=1S/C17H19N5/c1-12-18-16-14(17(19-12)22-10-6-3-7-11-22)20-15(21-16)13-8-4-2-5-9-13/h2,4-5,8-9H,3,6-7,10-11H2,1H3,(H,18,19,20,21)
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n/an/a 470n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093656
PNG
(2-Methoxy-6-phenyl-4-piperidin-1-yl-5H-pyrrolo[3,2...)
Show SMILES COc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C18H20N4O/c1-23-18-20-15-12-14(13-8-4-2-5-9-13)19-16(15)17(21-18)22-10-6-3-7-11-22/h2,4-5,8-9,12,19H,3,6-7,10-11H2,1H3
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n/an/a 540n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093630
PNG
((2-Methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl...)
Show SMILES Cc1nc(Nc2ccccc2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C19H16N4/c1-13-20-17-12-16(14-8-4-2-5-9-14)23-18(17)19(21-13)22-15-10-6-3-7-11-15/h2-12,23H,1H3,(H,20,21,22)
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n/an/a 540n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093636
PNG
(2-Methyl-6-phenyl-4-thiophen-3-yl-5H-pyrrolo[3,2-d...)
Show SMILES Cc1nc(-c2ccsc2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C17H13N3S/c1-11-18-15-9-14(12-5-3-2-4-6-12)20-17(15)16(19-11)13-7-8-21-10-13/h2-10,20H,1H3
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n/an/a 560n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093681
PNG
(7-Bromo-2-methyl-6-phenyl-4-piperidin-1-yl-5H-pyrr...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(c(Br)c2n1)-c1ccccc1
Show InChI InChI=1S/C18H19BrN4/c1-12-20-16-14(19)15(13-8-4-2-5-9-13)22-17(16)18(21-12)23-10-6-3-7-11-23/h2,4-5,8-9,22H,3,6-7,10-11H2,1H3
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n/an/a 580n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093660
PNG
(6-Phenyl-4-piperidin-1-yl-2-trifluoromethyl-5H-pyr...)
Show SMILES FC(F)(F)c1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C18H17F3N4/c19-18(20,21)17-23-14-11-13(12-7-3-1-4-8-12)22-15(14)16(24-17)25-9-5-2-6-10-25/h1,3-4,7-8,11,22H,2,5-6,9-10H2
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n/an/a 590n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093625
PNG
(6-(2-Chloro-phenyl)-2-methyl-4-piperidin-1-yl-5H-p...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1Cl
Show InChI InChI=1S/C18H19ClN4/c1-12-20-16-11-15(13-7-3-4-8-14(13)19)22-17(16)18(21-12)23-9-5-2-6-10-23/h3-4,7-8,11,22H,2,5-6,9-10H2,1H3
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n/an/a 660n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093638
PNG
(6-(4-Chloro-phenylsulfanylmethyl)-2-methyl-4-piper...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(CSc3ccc(Cl)cc3)cc2n1
Show InChI InChI=1S/C19H21ClN4S/c1-13-21-17-11-15(12-25-16-7-5-14(20)6-8-16)23-18(17)19(22-13)24-9-3-2-4-10-24/h5-8,11,23H,2-4,9-10,12H2,1H3
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n/an/a 670n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093627
PNG
((3-Ethoxy-propyl)-(2-methyl-6-phenyl-5H-pyrrolo[3,...)
Show SMILES CCOCCCNc1nc(C)nc2cc([nH]c12)-c1ccccc1
Show InChI InChI=1S/C18H22N4O/c1-3-23-11-7-10-19-18-17-16(20-13(2)21-18)12-15(22-17)14-8-5-4-6-9-14/h4-6,8-9,12,22H,3,7,10-11H2,1-2H3,(H,19,20,21)
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n/an/a 730n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093670
PNG
(2-[1-(2-Methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin...)
Show SMILES Cc1nc(N2CCCCC2CCO)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C20H24N4O/c1-14-21-18-13-17(15-7-3-2-4-8-15)23-19(18)20(22-14)24-11-6-5-9-16(24)10-12-25/h2-4,7-8,13,16,23,25H,5-6,9-12H2,1H3
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n/an/a 730n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093619
PNG
(CHEMBL336029 | N-(6-Phenyl-4-piperidin-1-yl-5H-pyr...)
Show SMILES O=C(Nc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H23N5O/c30-23(18-12-6-2-7-13-18)28-24-26-20-16-19(17-10-4-1-5-11-17)25-21(20)22(27-24)29-14-8-3-9-15-29/h1-2,4-7,10-13,16,25H,3,8-9,14-15H2,(H,26,27,28,30)
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n/an/a 750n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093631
PNG
(6-(4-Fluoro-benzyl)-2-methyl-4-piperidin-1-yl-5H-p...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(Cc3ccc(F)cc3)cc2n1
Show InChI InChI=1S/C19H21FN4/c1-13-21-17-12-16(11-14-5-7-15(20)8-6-14)23-18(17)19(22-13)24-9-3-2-4-10-24/h5-8,12,23H,2-4,9-11H2,1H3
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n/an/a 860n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50409035
PNG
(CHEMBL2111927)
Show SMILES COc1c([nH]c2c(nc(C)nc12)N1CCCCC1)-c1ccccc1
Show InChI InChI=1S/C19H22N4O/c1-13-20-16-17(19(21-13)23-11-7-4-8-12-23)22-15(18(16)24-2)14-9-5-3-6-10-14/h3,5-6,9-10,22H,4,7-8,11-12H2,1-2H3
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n/an/a 910n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093622
PNG
(6-Furan-2-yl-2-methyl-4-piperidin-1-yl-5H-pyrrolo[...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccco1
Show InChI InChI=1S/C16H18N4O/c1-11-17-13-10-12(14-6-5-9-21-14)19-15(13)16(18-11)20-7-3-2-4-8-20/h5-6,9-10,19H,2-4,7-8H2,1H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093637
PNG
(5-Methyl-2-phenyl-7-piperidin-1-yl-1H-pyrrolo[2,3-...)
Show SMILES Cc1cc2cc([nH]c2c(n1)N1CCCCC1)-c1ccccc1
Show InChI InChI=1S/C19H21N3/c1-14-12-16-13-17(15-8-4-2-5-9-15)21-18(16)19(20-14)22-10-6-3-7-11-22/h2,4-5,8-9,12-13,21H,3,6-7,10-11H2,1H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093671
PNG
(2,5-Dimethyl-6-phenyl-4-piperidin-1-yl-5H-pyrrolo[...)
Show SMILES Cc1nc(N2CCCCC2)c2n(C)c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C19H22N4/c1-14-20-16-13-17(15-9-5-3-6-10-15)22(2)18(16)19(21-14)23-11-7-4-8-12-23/h3,5-6,9-10,13H,4,7-8,11-12H2,1-2H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093634
PNG
(2-Methyl-4-piperidin-1-yl-6-pyrazin-2-yl-5H-pyrrol...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1cnccn1
Show InChI InChI=1S/C16H18N6/c1-11-19-13-9-12(14-10-17-5-6-18-14)21-15(13)16(20-11)22-7-3-2-4-8-22/h5-6,9-10,21H,2-4,7-8H2,1H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093655
PNG
(6-Biphenyl-4-yl-2-methyl-4-piperidin-1-yl-5H-pyrro...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C24H24N4/c1-17-25-22-16-21(27-23(22)24(26-17)28-14-6-3-7-15-28)20-12-10-19(11-13-20)18-8-4-2-5-9-18/h2,4-5,8-13,16,27H,3,6-7,14-15H2,1H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093648
PNG
(Benzyl-(2-methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimid...)
Show SMILES Cc1nc(NCc2ccccc2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C20H18N4/c1-14-22-18-12-17(16-10-6-3-7-11-16)24-19(18)20(23-14)21-13-15-8-4-2-5-9-15/h2-12,24H,13H2,1H3,(H,21,22,23)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093708
PNG
(7-Fluoro-2-methyl-6-phenyl-4-piperidin-1-yl-5H-pyr...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(c(F)c2n1)-c1ccccc1
Show InChI InChI=1S/C18H19FN4/c1-12-20-16-14(19)15(13-8-4-2-5-9-13)22-17(16)18(21-12)23-10-6-3-7-11-23/h2,4-5,8-9,22H,3,6-7,10-11H2,1H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093676
PNG
(6-Phenyl-4-piperidin-1-yl-5H-pyrrolo[3,2-d]pyrimid...)
Show SMILES C1CCN(CC1)c1ncnc2cc([nH]c12)-c1ccccc1
Show InChI InChI=1S/C17H18N4/c1-3-7-13(8-4-1)14-11-15-16(20-14)17(19-12-18-15)21-9-5-2-6-10-21/h1,3-4,7-8,11-12,20H,2,5-6,9-10H2
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n/an/a 2.30E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093680
PNG
(6-(4-Methoxy-benzyl)-2-methyl-4-piperidin-1-yl-5H-...)
Show SMILES COc1ccc(Cc2cc3nc(C)nc(N4CCCCC4)c3[nH]2)cc1
Show InChI InChI=1S/C20H24N4O/c1-14-21-18-13-16(12-15-6-8-17(25-2)9-7-15)23-19(18)20(22-14)24-10-4-3-5-11-24/h6-9,13,23H,3-5,10-12H2,1-2H3
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n/an/a 2.40E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093701
PNG
(2-Methyl-4-piperidin-1-yl-6-(2-trifluoromethyl-phe...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C19H19F3N4/c1-12-23-16-11-15(13-7-3-4-8-14(13)19(20,21)22)25-17(16)18(24-12)26-9-5-2-6-10-26/h3-4,7-8,11,25H,2,5-6,9-10H2,1H3
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n/an/a 2.50E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093677
PNG
((5-Methyl-furan-2-ylmethyl)-(2-methyl-6-phenyl-5H-...)
Show SMILES Cc1ccc(CNc2nc(C)nc3cc([nH]c23)-c2ccccc2)o1
Show InChI InChI=1S/C19H18N4O/c1-12-8-9-15(24-12)11-20-19-18-17(21-13(2)22-19)10-16(23-18)14-6-4-3-5-7-14/h3-10,23H,11H2,1-2H3,(H,20,21,22)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093635
PNG
(2-Methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-4-yla...)
Show SMILES Cc1nc(N)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C13H12N4/c1-8-15-11-7-10(9-5-3-2-4-6-9)17-12(11)13(14)16-8/h2-7,17H,1H3,(H2,14,15,16)
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n/an/a 3.10E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093620
PNG
((2-Methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl...)
Show SMILES Cc1nc(NCCN2CCOCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C19H23N5O/c1-14-21-17-13-16(15-5-3-2-4-6-15)23-18(17)19(22-14)20-7-8-24-9-11-25-12-10-24/h2-6,13,23H,7-12H2,1H3,(H,20,21,22)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093621
PNG
(6-Phenyl-2,4-di-piperidin-1-yl-5H-pyrrolo[3,2-d]py...)
Show SMILES C1CCN(CC1)c1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C22H27N5/c1-4-10-17(11-5-1)18-16-19-20(23-18)21(26-12-6-2-7-13-26)25-22(24-19)27-14-8-3-9-15-27/h1,4-5,10-11,16,23H,2-3,6-9,12-15H2
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n/an/a 4.00E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093611
PNG
(2-Methylsulfanyl-6-phenyl-4-piperidin-1-yl-5H-pyrr...)
Show SMILES CSc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C18H20N4S/c1-23-18-20-15-12-14(13-8-4-2-5-9-13)19-16(15)17(21-18)22-10-6-3-7-11-22/h2,4-5,8-9,12,19H,3,6-7,10-11H2,1H3
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n/an/a 4.70E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093612
PNG
(1-(2-Methyl-6-phenyl-4-piperidin-1-yl-5H-pyrrolo[3...)
Show SMILES CC(=O)c1c([nH]c2c(nc(C)nc12)N1CCCCC1)-c1ccccc1
Show InChI InChI=1S/C20H22N4O/c1-13(25)16-17(15-9-5-3-6-10-15)23-19-18(16)21-14(2)22-20(19)24-11-7-4-8-12-24/h3,5-6,9-10,23H,4,7-8,11-12H2,1-2H3
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n/an/a 5.10E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093690
PNG
(CHEMBL137356 | Dimethyl-[1-(2-methyl-6-phenyl-5H-p...)
Show SMILES CN(C)CC1CCCCN1c1nc(C)nc2cc([nH]c12)-c1ccccc1
Show InChI InChI=1S/C21H27N5/c1-15-22-19-13-18(16-9-5-4-6-10-16)24-20(19)21(23-15)26-12-8-7-11-17(26)14-25(2)3/h4-6,9-10,13,17,24H,7-8,11-12,14H2,1-3H3
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n/an/a 5.20E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093665
PNG
(1-[4-(2-Methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin...)
Show SMILES CC(=O)N1CCN(CC1)c1nc(C)nc2cc([nH]c12)-c1ccccc1
Show InChI InChI=1S/C19H21N5O/c1-13-20-17-12-16(15-6-4-3-5-7-15)22-18(17)19(21-13)24-10-8-23(9-11-24)14(2)25/h3-7,12,22H,8-11H2,1-2H3
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n/an/a 6.00E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093617
PNG
(2-Methyl-6-phenyl-4-piperazin-1-yl-5H-pyrrolo[3,2-...)
Show SMILES Cc1nc(N2CCNCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C17H19N5/c1-12-19-15-11-14(13-5-3-2-4-6-13)21-16(15)17(20-12)22-9-7-18-8-10-22/h2-6,11,18,21H,7-10H2,1H3
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n/an/a 7.20E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093669
PNG
(4-(4-Methanesulfonyl-piperazin-1-yl)-2-methyl-6-ph...)
Show SMILES Cc1nc(N2CCN(CC2)S(C)(=O)=O)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C18H21N5O2S/c1-13-19-16-12-15(14-6-4-3-5-7-14)21-17(16)18(20-13)22-8-10-23(11-9-22)26(2,24)25/h3-7,12,21H,8-11H2,1-2H3
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n/an/a 7.50E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093645
PNG
((2-Ethyl-heptyl)-(2-methyl-6-phenyl-5H-pyrrolo[3,2...)
Show SMILES CCCCCC(CC)CNc1nc(C)nc2cc([nH]c12)-c1ccccc1
Show InChI InChI=1S/C22H30N4/c1-4-6-8-11-17(5-2)15-23-22-21-20(24-16(3)25-22)14-19(26-21)18-12-9-7-10-13-18/h7,9-10,12-14,17,26H,4-6,8,11,15H2,1-3H3,(H,23,24,25)
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n/an/a 7.80E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093705
PNG
(4-Cyclohexyl-2-methyl-6-phenyl-5H-pyrrolo[3,2-d]py...)
Show SMILES Cc1nc(C2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C19H21N3/c1-13-20-17-12-16(14-8-4-2-5-9-14)22-19(17)18(21-13)15-10-6-3-7-11-15/h2,4-5,8-9,12,15,22H,3,6-7,10-11H2,1H3
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n/an/a 8.20E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093685
PNG
(2-Isopropyl-6-phenyl-4-piperidin-1-yl-5H-pyrrolo[3...)
Show SMILES CC(C)c1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C20H24N4/c1-14(2)19-22-17-13-16(15-9-5-3-6-10-15)21-18(17)20(23-19)24-11-7-4-8-12-24/h3,5-6,9-10,13-14,21H,4,7-8,11-12H2,1-2H3
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n/an/a 8.30E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093643
PNG
(6-(4-Chloro-benzenesulfonylmethyl)-2-methyl-4-pipe...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(CS(=O)(=O)c3ccc(Cl)cc3)cc2n1
Show InChI InChI=1S/C19H21ClN4O2S/c1-13-21-17-11-15(12-27(25,26)16-7-5-14(20)6-8-16)23-18(17)19(22-13)24-9-3-2-4-10-24/h5-8,11,23H,2-4,9-10,12H2,1H3
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n/an/a 8.50E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093626
PNG
(2-Methyl-6-phenyl-4-pyridin-3-yl-5H-pyrrolo[3,2-d]...)
Show SMILES Cc1nc(-c2cccnc2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C18H14N4/c1-12-20-16-10-15(13-6-3-2-4-7-13)22-18(16)17(21-12)14-8-5-9-19-11-14/h2-11,22H,1H3
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n/an/a 8.50E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093688
PNG
(2,6-Diphenyl-4-piperidin-1-yl-5H-pyrrolo[3,2-d]pyr...)
Show SMILES C1CCN(CC1)c1nc(nc2cc([nH]c12)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C23H22N4/c1-4-10-17(11-5-1)19-16-20-21(24-19)23(27-14-8-3-9-15-27)26-22(25-20)18-12-6-2-7-13-18/h1-2,4-7,10-13,16,24H,3,8-9,14-15H2
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n/an/a 9.30E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093661
PNG
(CHEMBL341791 | Dimethyl-[1-(2-methyl-6-phenyl-5H-p...)
Show SMILES CN(C)C1CCN(CC1)c1nc(C)nc2cc([nH]c12)-c1ccccc1
Show InChI InChI=1S/C20H25N5/c1-14-21-18-13-17(15-7-5-4-6-8-15)23-19(18)20(22-14)25-11-9-16(10-12-25)24(2)3/h4-8,13,16,23H,9-12H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093610
PNG
((2-Methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl...)
Show SMILES Cc1nc(NCC(F)(F)F)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C15H13F3N4/c1-9-20-12-7-11(10-5-3-2-4-6-10)22-13(12)14(21-9)19-8-15(16,17)18/h2-7,22H,8H2,1H3,(H,19,20,21)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%