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PubMed code 11527715

Compile data set for download or QSAR
Found 33 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50073048
PNG
(2-[4-(2-Oxo-2,3-dihydro-benzoimidazol-1-yl)-piperi...)
Show SMILES O=C(CN1CCC(CC1)n1c2ccccc2[nH]c1=O)Nc1ccc2C(=O)c3ccccc3-c2c1
Show InChI InChI=1S/C27H24N4O3/c32-25(28-17-9-10-21-22(15-17)19-5-1-2-6-20(19)26(21)33)16-30-13-11-18(12-14-30)31-24-8-4-3-7-23(24)29-27(31)34/h1-10,15,18H,11-14,16H2,(H,28,32)(H,29,34)
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n/an/a 0.470n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity of the compound against human Neuropeptide Y receptor type 5 in HEK 293 cell line by using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00448-6
BindingDB Entry DOI: 10.7270/Q2NZ86WB
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50103700
PNG
(CHEMBL3084801 | N-{4-[5-Amino-1-(4-trifluoromethyl...)
Show SMILES Nc1cc(nn1-c1ccc(cc1)C(F)(F)F)C1CCC(CNS(=O)(=O)c2ccccc2[N+]([O-])=O)CC1
Show InChI InChI=1S/C23H24F3N5O4S/c24-23(25,26)17-9-11-18(12-10-17)30-22(27)13-19(29-30)16-7-5-15(6-8-16)14-28-36(34,35)21-4-2-1-3-20(21)31(32)33/h1-4,9-13,15-16,28H,5-8,14,27H2
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n/an/a 10n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human neuropeptide Y receptor type 5 in HEK 293 cell line, using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00448-6
BindingDB Entry DOI: 10.7270/Q2NZ86WB
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50103712
PNG
(CHEMBL430414 | N-[4-(5-Amino-1-p-tolyl-1H-pyrazol-...)
Show SMILES COc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1cc(N)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C23H22N4O3S/c1-16-3-9-19(10-4-16)27-23(24)15-22(25-27)17-5-7-18(8-6-17)26-31(28,29)21-13-11-20(30-2)12-14-21/h3-15,26H,24H2,1-2H3
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n/an/a 15n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human neuropeptide Y receptor type 5 in HEK 293 cell line, using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00448-6
BindingDB Entry DOI: 10.7270/Q2NZ86WB
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50103715
PNG
(2-Amino-N-{4-[5-amino-1-(4-trifluoromethyl-phenyl)...)
Show SMILES Nc1cc(nn1-c1ccc(cc1)C(F)(F)F)C1CCC(CNS(=O)(=O)c2ccccc2N)CC1
Show InChI InChI=1S/C23H26F3N5O2S/c24-23(25,26)17-9-11-18(12-10-17)31-22(28)13-20(30-31)16-7-5-15(6-8-16)14-29-34(32,33)21-4-2-1-3-19(21)27/h1-4,9-13,15-16,29H,5-8,14,27-28H2
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n/an/a 20n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human neuropeptide Y receptor type 5 in HEK 293 cell line, using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00448-6
BindingDB Entry DOI: 10.7270/Q2NZ86WB
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50103708
PNG
(CHEMBL75823 | N-[4-(5-Amino-1-p-tolyl-1H-pyrazol-3...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1N)-c1ccc(NS(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C22H20N4O2S/c1-16-7-13-19(14-8-16)26-22(23)15-21(24-26)17-9-11-18(12-10-17)25-29(27,28)20-5-3-2-4-6-20/h2-15,25H,23H2,1H3
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n/an/a 25n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human neuropeptide Y receptor type 5 in HEK 293 cell line, using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00448-6
BindingDB Entry DOI: 10.7270/Q2NZ86WB
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50103691
PNG
(CHEMBL72547 | N-[4-(5-Amino-1-p-tolyl-1H-pyrazol-3...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1N)-c1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C22H19FN4O2S/c1-15-2-10-19(11-3-15)27-22(24)14-21(25-27)16-4-8-18(9-5-16)26-30(28,29)20-12-6-17(23)7-13-20/h2-14,26H,24H2,1H3
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n/an/a 29n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human neuropeptide Y receptor type 5 in HEK 293 cell line, using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00448-6
BindingDB Entry DOI: 10.7270/Q2NZ86WB
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50103694
PNG
(CHEMBL73643 | N-{4-[5-Amino-1-(3-dimethylamino-phe...)
Show SMILES COc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1cc(N)n(n1)-c1cccc(c1)N(C)C
Show InChI InChI=1S/C24H25N5O3S/c1-28(2)19-5-4-6-20(15-19)29-24(25)16-23(26-29)17-7-9-18(10-8-17)27-33(30,31)22-13-11-21(32-3)12-14-22/h4-16,27H,25H2,1-3H3
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n/an/a 30n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human neuropeptide Y receptor type 5 in HEK 293 cell line, using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00448-6
BindingDB Entry DOI: 10.7270/Q2NZ86WB
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50103707
PNG
(CHEMBL444319 | N-[4-(5-Amino-1-m-tolyl-1H-pyrazol-...)
Show SMILES COc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1cc(N)n(n1)-c1cccc(C)c1
Show InChI InChI=1S/C23H22N4O3S/c1-16-4-3-5-19(14-16)27-23(24)15-22(25-27)17-6-8-18(9-7-17)26-31(28,29)21-12-10-20(30-2)11-13-21/h3-15,26H,24H2,1-2H3
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n/an/a 37n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human neuropeptide Y receptor type 5 in HEK 293 cell line, using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00448-6
BindingDB Entry DOI: 10.7270/Q2NZ86WB
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50103692
PNG
(CHEMBL73401 | N-{4-[5-Amino-1-(4-fluoro-phenyl)-1H...)
Show SMILES COc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1cc(N)n(n1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H19FN4O3S/c1-30-19-10-12-20(13-11-19)31(28,29)26-17-6-2-15(3-7-17)21-14-22(24)27(25-21)18-8-4-16(23)5-9-18/h2-14,26H,24H2,1H3
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n/an/a 37n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human neuropeptide Y receptor type 5 in HEK 293 cell line, using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00448-6
BindingDB Entry DOI: 10.7270/Q2NZ86WB
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50103688
PNG
(CHEMBL72133 | N-[4-(5-Amino-1-p-tolyl-1H-pyrazol-3...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1N)-c1ccc(NS(=O)(=O)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C23H22N4O2S/c1-16-3-11-20(12-4-16)27-23(24)15-22(25-27)18-7-9-19(10-8-18)26-30(28,29)21-13-5-17(2)6-14-21/h3-15,26H,24H2,1-2H3
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n/an/a 40n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human neuropeptide Y receptor type 5 in HEK 293 cell line, using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00448-6
BindingDB Entry DOI: 10.7270/Q2NZ86WB
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50103690
PNG
(CHEMBL307458 | N-[4-(5-Amino-1-naphthalen-1-yl-1H-...)
Show SMILES COc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1cc(N)n(n1)-c1cccc2ccccc12
Show InChI InChI=1S/C26H22N4O3S/c1-33-21-13-15-22(16-14-21)34(31,32)29-20-11-9-19(10-12-20)24-17-26(27)30(28-24)25-8-4-6-18-5-2-3-7-23(18)25/h2-17,29H,27H2,1H3
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n/an/a 48n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human neuropeptide Y receptor type 5 in HEK 293 cell line, using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00448-6
BindingDB Entry DOI: 10.7270/Q2NZ86WB
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50103701
PNG
(CHEMBL75827 | N-[4-(5-Amino-1-p-tolyl-1H-pyrazol-3...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1N)-c1ccc(NS(=O)(=O)c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C23H19F3N4O2S/c1-15-2-10-19(11-3-15)30-22(27)14-21(28-30)16-4-8-18(9-5-16)29-33(31,32)20-12-6-17(7-13-20)23(24,25)26/h2-14,29H,27H2,1H3
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n/an/a 63n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human neuropeptide Y receptor type 5 in HEK 293 cell line, using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00448-6
BindingDB Entry DOI: 10.7270/Q2NZ86WB
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50103699
PNG
(CHEMBL308110 | N-[4-(5-Amino-1-p-tolyl-1H-pyrazol-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1N)-c1ccc(NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1S/C23H19F3N4O3S/c1-15-2-8-18(9-3-15)30-22(27)14-21(28-30)16-4-6-17(7-5-16)29-34(31,32)20-12-10-19(11-13-20)33-23(24,25)26/h2-14,29H,27H2,1H3
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n/an/a 67n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human neuropeptide Y receptor type 5 in HEK 293 cell line, using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00448-6
BindingDB Entry DOI: 10.7270/Q2NZ86WB
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50103696
PNG
(4-Amino-N-[4-(5-amino-1-p-tolyl-1H-pyrazol-3-yl)-p...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1N)-c1ccc(NS(=O)(=O)c2ccc(N)cc2)cc1
Show InChI InChI=1S/C22H21N5O2S/c1-15-2-10-19(11-3-15)27-22(24)14-21(25-27)16-4-8-18(9-5-16)26-30(28,29)20-12-6-17(23)7-13-20/h2-14,26H,23-24H2,1H3
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n/an/a 74n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human neuropeptide Y receptor type 5 in HEK 293 cell line, using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00448-6
BindingDB Entry DOI: 10.7270/Q2NZ86WB
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50103713
PNG
(CHEMBL73251 | N-[4-(5-Amino-1-p-tolyl-1H-pyrazol-3...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1N)-c1ccc(NS(=O)(=O)c2ccc(cc2)[N+]([O-])=O)cc1
Show InChI InChI=1S/C22H19N5O4S/c1-15-2-8-18(9-3-15)26-22(23)14-21(24-26)16-4-6-17(7-5-16)25-32(30,31)20-12-10-19(11-13-20)27(28)29/h2-14,25H,23H2,1H3
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n/an/a 79n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human neuropeptide Y receptor type 5 in HEK 293 cell line, using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00448-6
BindingDB Entry DOI: 10.7270/Q2NZ86WB
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50103716
PNG
(CHEMBL75662 | N-[4-(5-Amino-1-phenyl-1H-pyrazol-3-...)
Show SMILES COc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1cc(N)n(n1)-c1ccccc1
Show InChI InChI=1S/C22H20N4O3S/c1-29-19-11-13-20(14-12-19)30(27,28)25-17-9-7-16(8-10-17)21-15-22(23)26(24-21)18-5-3-2-4-6-18/h2-15,25H,23H2,1H3
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n/an/a 100n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human neuropeptide Y receptor type 5 in HEK 293 cell line, using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00448-6
BindingDB Entry DOI: 10.7270/Q2NZ86WB
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50103703
PNG
(CHEMBL308508 | N-{4-[5-Amino-1-(4-trifluoromethyl-...)
Show SMILES Nc1cc(nn1-c1ccc(cc1)C(F)(F)F)-c1ccc(CNS(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C23H19F3N4O2S/c24-23(25,26)18-10-12-19(13-11-18)30-22(27)14-21(29-30)17-8-6-16(7-9-17)15-28-33(31,32)20-4-2-1-3-5-20/h1-14,28H,15,27H2
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n/an/a 114n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human neuropeptide Y receptor type 5 in HEK 293 cell line, using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00448-6
BindingDB Entry DOI: 10.7270/Q2NZ86WB
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50103697
PNG
(CHEMBL75369 | N-[4-(5-Amino-1-p-tolyl-1H-pyrazol-3...)
Show SMILES CN(C)c1cccc(c1)S(=O)(=O)Nc1ccc(cc1)-c1cc(N)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C24H25N5O2S/c1-17-7-13-20(14-8-17)29-24(25)16-23(26-29)18-9-11-19(12-10-18)27-32(30,31)22-6-4-5-21(15-22)28(2)3/h4-16,27H,25H2,1-3H3
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n/an/a 145n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human neuropeptide Y receptor type 5 in HEK 293 cell line, using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00448-6
BindingDB Entry DOI: 10.7270/Q2NZ86WB
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50103693
PNG
(CHEMBL432352 | N-[4-(5-Amino-1-p-tolyl-1H-pyrazol-...)
Show SMILES CN(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1cc(N)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C24H25N5O2S/c1-17-4-10-21(11-5-17)29-24(25)16-23(26-29)18-6-8-19(9-7-18)27-32(30,31)22-14-12-20(13-15-22)28(2)3/h4-16,27H,25H2,1-3H3
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n/an/a 162n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human neuropeptide Y receptor type 5 in HEK 293 cell line, using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00448-6
BindingDB Entry DOI: 10.7270/Q2NZ86WB
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50103711
PNG
(CHEMBL307901 | N-[4-(5-Amino-1-p-tolyl-1H-pyrazol-...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1N)-c1ccc(NS(=O)(=O)c2ccccc2[N+]([O-])=O)cc1
Show InChI InChI=1S/C22H19N5O4S/c1-15-6-12-18(13-7-15)26-22(23)14-19(24-26)16-8-10-17(11-9-16)25-32(30,31)21-5-3-2-4-20(21)27(28)29/h2-14,25H,23H2,1H3
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n/an/a 178n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human neuropeptide Y receptor type 5 in HEK 293 cell line, using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00448-6
BindingDB Entry DOI: 10.7270/Q2NZ86WB
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50103689
PNG
(2-Amino-N-[4-(5-amino-1-p-tolyl-1H-pyrazol-3-yl)-p...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1N)-c1ccc(NS(=O)(=O)c2ccccc2N)cc1
Show InChI InChI=1S/C22H21N5O2S/c1-15-6-12-18(13-7-15)27-22(24)14-20(25-27)16-8-10-17(11-9-16)26-30(28,29)21-5-3-2-4-19(21)23/h2-14,26H,23-24H2,1H3
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n/an/a 229n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human neuropeptide Y receptor type 5 in HEK 293 cell line, using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00448-6
BindingDB Entry DOI: 10.7270/Q2NZ86WB
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50103709
PNG
(3-Amino-N-[4-(5-amino-1-p-tolyl-1H-pyrazol-3-yl)-p...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1N)-c1ccc(NS(=O)(=O)c2cccc(N)c2)cc1
Show InChI InChI=1S/C22H21N5O2S/c1-15-5-11-19(12-6-15)27-22(24)14-21(25-27)16-7-9-18(10-8-16)26-30(28,29)20-4-2-3-17(23)13-20/h2-14,26H,23-24H2,1H3
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n/an/a 303n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human neuropeptide Y receptor type 5 in HEK 293 cell line, using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00448-6
BindingDB Entry DOI: 10.7270/Q2NZ86WB
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50103710
PNG
(CHEMBL307462 | N-[4-(5-Amino-1-pyridin-2-yl-1H-pyr...)
Show SMILES COc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1cc(N)n(n1)-c1ccccn1
Show InChI InChI=1S/C21H19N5O3S/c1-29-17-9-11-18(12-10-17)30(27,28)25-16-7-5-15(6-8-16)19-14-20(22)26(24-19)21-4-2-3-13-23-21/h2-14,25H,22H2,1H3
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n/an/a 436n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human neuropeptide Y receptor type 5 in HEK 293 cell line, using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00448-6
BindingDB Entry DOI: 10.7270/Q2NZ86WB
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50103702
PNG
(4-Dimethylamino-N-[4-(5-methylamino-1-p-tolyl-1H-p...)
Show SMILES CNc1cc(nn1-c1ccc(C)cc1)-c1ccc(NS(=O)(=O)c2ccc(cc2)N(C)C)cc1
Show InChI InChI=1S/C25H27N5O2S/c1-18-5-11-22(12-6-18)30-25(26-2)17-24(27-30)19-7-9-20(10-8-19)28-33(31,32)23-15-13-21(14-16-23)29(3)4/h5-17,26,28H,1-4H3
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n/an/a 487n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human neuropeptide Y receptor type 5 in HEK 293 cell line, using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00448-6
BindingDB Entry DOI: 10.7270/Q2NZ86WB
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50103714
PNG
(3-{5-Amino-3-[4-(4-methoxy-benzenesulfonylamino)-p...)
Show SMILES COc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1cc(N)n(n1)-c1c[n+](ccn1)C(F)(F)F
Show InChI InChI=1S/C21H18F3N6O3S/c1-33-16-6-8-17(9-7-16)34(31,32)28-15-4-2-14(3-5-15)18-12-19(25)30(27-18)20-13-29(11-10-26-20)21(22,23)24/h2-13,28H,25H2,1H3/q+1
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n/an/a 709n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human neuropeptide Y receptor type 5 in HEK 293 cell line, using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00448-6
BindingDB Entry DOI: 10.7270/Q2NZ86WB
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50103704
PNG
(CHEMBL73990 | N-[4-(5-Amino-1-p-tolyl-1H-pyrazol-3...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(C)c1ccc(cc1)-c1cc(N)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C24H24N4O3S/c1-17-4-8-20(9-5-17)28-24(25)16-23(26-28)18-6-10-19(11-7-18)27(2)32(29,30)22-14-12-21(31-3)13-15-22/h4-16H,25H2,1-3H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity of the compound against human Neuropeptide Y receptor type 5 in HEK 293 cell line by using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00448-6
BindingDB Entry DOI: 10.7270/Q2NZ86WB
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50103698
PNG
(CHEMBL419453 | Quinoline-8-sulfonic acid [4-(5-ami...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1N)-c1ccc(NS(=O)(=O)c2cccc3cccnc23)cc1
Show InChI InChI=1S/C25H21N5O2S/c1-17-7-13-21(14-8-17)30-24(26)16-22(28-30)18-9-11-20(12-10-18)29-33(31,32)23-6-2-4-19-5-3-15-27-25(19)23/h2-16,29H,26H2,1H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human neuropeptide Y receptor type 5 in HEK 293 cell line, using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00448-6
BindingDB Entry DOI: 10.7270/Q2NZ86WB
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50103695
PNG
(CHEMBL307611 | N-{4-[5-Amino-1-(3,5-bis-trifluorom...)
Show SMILES COc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1cc(N)n(n1)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C24H18F6N4O3S/c1-37-19-6-8-20(9-7-19)38(35,36)33-17-4-2-14(3-5-17)21-13-22(31)34(32-21)18-11-15(23(25,26)27)10-16(12-18)24(28,29)30/h2-13,33H,31H2,1H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human neuropeptide Y receptor type 5 in HEK 293 cell line, using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00448-6
BindingDB Entry DOI: 10.7270/Q2NZ86WB
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50103705
PNG
(CHEMBL72742 | N-{4-[5-Amino-1-(4-trifluoromethyl-p...)
Show SMILES COc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1cc(N)n(n1)-c1cc(ccn1)C(F)(F)F
Show InChI InChI=1S/C22H18F3N5O3S/c1-33-17-6-8-18(9-7-17)34(31,32)29-16-4-2-14(3-5-16)19-13-20(26)30(28-19)21-12-15(10-11-27-21)22(23,24)25/h2-13,29H,26H2,1H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human neuropeptide Y receptor type 5 in HEK 293 cell line, using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00448-6
BindingDB Entry DOI: 10.7270/Q2NZ86WB
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50103687
PNG
(CHEMBL73500 | Naphthalene-1-sulfonic acid [4-(5-am...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1N)-c1ccc(NS(=O)(=O)c2cccc3ccccc23)cc1
Show InChI InChI=1S/C26H22N4O2S/c1-18-9-15-22(16-10-18)30-26(27)17-24(28-30)20-11-13-21(14-12-20)29-33(31,32)25-8-4-6-19-5-2-3-7-23(19)25/h2-17,29H,27H2,1H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human neuropeptide Y receptor type 5 in HEK 293 cell line, using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00448-6
BindingDB Entry DOI: 10.7270/Q2NZ86WB
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50103706
PNG
(CHEMBL306111 | N-[3-(5-Amino-1-p-tolyl-1H-pyrazol-...)
Show SMILES COc1ccc(cc1)S(=O)(=O)Nc1cccc(c1)-c1cc(N)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C23H22N4O3S/c1-16-6-8-19(9-7-16)27-23(24)15-22(25-27)17-4-3-5-18(14-17)26-31(28,29)21-12-10-20(30-2)11-13-21/h3-15,26H,24H2,1-2H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human neuropeptide Y receptor type 5 in HEK 293 cell line, using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00448-6
BindingDB Entry DOI: 10.7270/Q2NZ86WB
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50103686
PNG
(CHEMBL73384 | N-[4-(5-Amino-1-p-tolyl-1H-pyrazol-3...)
Show SMILES COc1ccc(cc1)C(=O)Nc1ccc(cc1)-c1cc(N)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C24H22N4O2/c1-16-3-11-20(12-4-16)28-23(25)15-22(27-28)17-5-9-19(10-6-17)26-24(29)18-7-13-21(30-2)14-8-18/h3-15H,25H2,1-2H3,(H,26,29)
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n/an/a>3.00E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human neuropeptide Y receptor type 5 in HEK 293 cell line, using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00448-6
BindingDB Entry DOI: 10.7270/Q2NZ86WB
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50103717
PNG
(4-(5-Amino-1-p-tolyl-1H-pyrazol-3-yl)-N-p-tolyl-be...)
Show SMILES Cc1ccc(NC(=O)c2ccc(cc2)-c2cc(N)n(n2)-c2ccc(C)cc2)cc1
Show InChI InChI=1S/C24H22N4O/c1-16-3-11-20(12-4-16)26-24(29)19-9-7-18(8-10-19)22-15-23(25)28(27-22)21-13-5-17(2)6-14-21/h3-15H,25H2,1-2H3,(H,26,29)
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n/an/a>3.00E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human neuropeptide Y receptor type 5 in HEK 293 cell line, using [125I]-PYY as radioligand


Bioorg Med Chem Lett 11: 2283-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00448-6
BindingDB Entry DOI: 10.7270/Q2NZ86WB
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%