Compile Data Set for Download or QSAR
maximum 50k data
Found 13 Enz. Inhib. hit(s) with all data for entry = 1546
TargetCaspase-1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM12197((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydr...)
Affinity DataKi:  11nM ΔG°:  -47.3kJ/molepH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM12055((3S)-4-oxo-3-[(2-phenylbenzene)sulfonamido]butanoi...)
Affinity DataKi:  1.60E+3nM ΔG°:  -34.4kJ/molepH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM12049((3S)-3-[(3-methyl-2-phenylbenzene)sulfonamido]-4-o...)
Affinity DataKi:  1.90E+3nM ΔG°:  -34.0kJ/molepH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM12054((3S)-3-{[2-(3-acetamidophenyl)benzene]sulfonamido}...)
Affinity DataKi:  2.30E+3nM ΔG°:  -33.5kJ/molepH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM12051((3S)-3-{[2-(3-methylphenyl)benzene]sulfonamido}-4-...)
Affinity DataKi:  3.10E+3nM ΔG°:  -32.7kJ/molepH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM12050((3S)-3-{[2-(2-methylphenyl)benzene]sulfonamido}-4-...)
Affinity DataKi:  6.80E+3nM ΔG°:  -30.7kJ/molepH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM12053((3S)-3-{[2-(naphthalen-1-yl)benzene]sulfonamido}-4...)
Affinity DataKi:  6.90E+3nM ΔG°:  -30.6kJ/molepH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM12052((3S)-3-{[2-(4-methylphenyl)benzene]sulfonamido}-4-...)
Affinity DataKi:  7.20E+3nM ΔG°:  -30.5kJ/molepH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM12047((3S)-3-benzenesulfonamido-4-oxobutanoic acid | (S)...)
Affinity DataKi:  9.40E+3nM ΔG°:  -29.8kJ/molepH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM12045((3S)-3-benzenesulfonamido-4-oxo-9-phenylnonanoic a...)
Affinity DataKi:  2.40E+4nM ΔG°:  -27.4kJ/molepH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM12046((3S)-3-benzenesulfonamido-4-oxo-5-[(3-phenylpropyl...)
Affinity DataKi:  2.40E+4nM ΔG°:  -27.4kJ/molepH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM12044((3S)-3-{[(benzyloxy)carbonyl]amino}-4-oxo-5-[(3-ph...)
Affinity DataKi:  2.50E+4nM ΔG°:  -27.3kJ/molepH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM12043((3S)-3-{[(benzyloxy)carbonyl]amino}-4-oxo-9-phenyl...)
Affinity DataKi:  1.19E+5nM ΔG°:  -23.3kJ/molepH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed