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PubMed code 11859006

Compile data set for download or QSAR
Found 15 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50110571
PNG
(CHEMBL167991 | FR-230481 | Naphthalene-1-sulfonic ...)
Show SMILES COc1ccc2CCCC(O)(CNCC3CCN(CCNS(=O)(=O)c4cccc5ccccc45)CC3)c2c1
Show InChI InChI=1S/C30H39N3O4S/c1-37-26-12-11-25-8-5-15-30(34,28(25)20-26)22-31-21-23-13-17-33(18-14-23)19-16-32-38(35,36)29-10-4-7-24-6-2-3-9-27(24)29/h2-4,6-7,9-12,20,23,31-32,34H,5,8,13-19,21-22H2,1H3
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n/an/a 0.540n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of 125 I-PYY binding to human Neuropeptide Y receptor type 5


Bioorg Med Chem Lett 12: 799-802 (2002)


Article DOI: 10.1016/s0960-894x(02)00018-5
BindingDB Entry DOI: 10.7270/Q2M044R7
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50110562
PNG
(5-Chloro-3-(2-{4-[(3-methoxy-6,7,8,9-tetrahydro-5H...)
Show SMILES COc1ccc2CCCC(Cc2c1)NCC1CCN(CC1)C(=O)Cn1c2cc(Cl)ccc2sc1=O
Show InChI InChI=1S/C27H32ClN3O3S/c1-34-23-7-5-19-3-2-4-22(13-20(19)14-23)29-16-18-9-11-30(12-10-18)26(32)17-31-24-15-21(28)6-8-25(24)35-27(31)33/h5-8,14-15,18,22,29H,2-4,9-13,16-17H2,1H3
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n/an/a 0.700n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of 125 I-PYY binding to human Neuropeptide Y receptor type 5


Bioorg Med Chem Lett 12: 799-802 (2002)


Article DOI: 10.1016/s0960-894x(02)00018-5
BindingDB Entry DOI: 10.7270/Q2M044R7
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50110567
PNG
(1-[2-(5-Chloro-2-oxo-benzothiazol-3-yl)-acetyl]-pi...)
Show SMILES COc1ccc2CCCC(O)(CNC(=O)C3CCN(CC3)C(=O)Cn3c4cc(Cl)ccc4sc3=O)c2c1
Show InChI InChI=1S/C27H30ClN3O5S/c1-36-20-6-4-17-3-2-10-27(35,21(17)14-20)16-29-25(33)18-8-11-30(12-9-18)24(32)15-31-22-13-19(28)5-7-23(22)37-26(31)34/h4-7,13-14,18,35H,2-3,8-12,15-16H2,1H3,(H,29,33)
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n/an/a 1n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of 125 I-PYY binding to human Neuropeptide Y receptor type 5


Bioorg Med Chem Lett 12: 799-802 (2002)


Article DOI: 10.1016/s0960-894x(02)00018-5
BindingDB Entry DOI: 10.7270/Q2M044R7
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50110569
PNG
(1-[2-(5-Chloro-2-oxo-benzothiazol-3-yl)-acetyl]-pi...)
Show SMILES COc1ccc2CCCC(CNC(=O)C3CCN(CC3)C(=O)Cn3c4cc(Cl)ccc4sc3=O)Cc2c1
Show InChI InChI=1S/C28H32ClN3O4S/c1-36-23-7-5-19-4-2-3-18(13-21(19)14-23)16-30-27(34)20-9-11-31(12-10-20)26(33)17-32-24-15-22(29)6-8-25(24)37-28(32)35/h5-8,14-15,18,20H,2-4,9-13,16-17H2,1H3,(H,30,34)
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n/an/a 1.20n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of 125 I-PYY binding to human Neuropeptide Y receptor type 5


Bioorg Med Chem Lett 12: 799-802 (2002)


Article DOI: 10.1016/s0960-894x(02)00018-5
BindingDB Entry DOI: 10.7270/Q2M044R7
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50110565
PNG
(CHEMBL164873 | Naphthalene-1-sulfonic acid (2-{4-[...)
Show SMILES COc1ccc2CCCC(Cc2c1)NCC1CCN(CC1)C(=O)CNS(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C30H37N3O4S/c1-37-27-13-12-23-7-4-9-26(18-25(23)19-27)31-20-22-14-16-33(17-15-22)30(34)21-32-38(35,36)29-11-5-8-24-6-2-3-10-28(24)29/h2-3,5-6,8,10-13,19,22,26,31-32H,4,7,9,14-18,20-21H2,1H3
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n/an/a 3.70n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of 125 I-PYY binding to human Neuropeptide Y receptor type 5


Bioorg Med Chem Lett 12: 799-802 (2002)


Article DOI: 10.1016/s0960-894x(02)00018-5
BindingDB Entry DOI: 10.7270/Q2M044R7
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50110573
PNG
(3-Chloro-N-[2-(4-{[(1-hydroxy-7-methoxy-1,2,3,4-te...)
Show SMILES COc1ccc2CCCC(O)(CNCC3CCN(CCNS(=O)(=O)c4cccc(Cl)c4C)CC3)c2c1
Show InChI InChI=1S/C27H38ClN3O4S/c1-20-25(28)6-3-7-26(20)36(33,34)30-13-16-31-14-10-21(11-15-31)18-29-19-27(32)12-4-5-22-8-9-23(35-2)17-24(22)27/h3,6-9,17,21,29-30,32H,4-5,10-16,18-19H2,1-2H3
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n/an/a 11n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of 125 I-PYY binding to human Neuropeptide Y receptor type 5


Bioorg Med Chem Lett 12: 799-802 (2002)


Article DOI: 10.1016/s0960-894x(02)00018-5
BindingDB Entry DOI: 10.7270/Q2M044R7
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50110572
PNG
(CHEMBL167860 | N-[2-(4-{[(1-Hydroxy-7-methoxy-1,2,...)
Show SMILES COc1ccc2CCCC(O)(CNCC3CCN(CCNS(=O)(=O)c4cccc(C)c4)CC3)c2c1
Show InChI InChI=1S/C27H39N3O4S/c1-21-5-3-7-25(17-21)35(32,33)29-13-16-30-14-10-22(11-15-30)19-28-20-27(31)12-4-6-23-8-9-24(34-2)18-26(23)27/h3,5,7-9,17-18,22,28-29,31H,4,6,10-16,19-20H2,1-2H3
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n/an/a 13n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of 125 I-PYY binding to human Neuropeptide Y receptor type 5


Bioorg Med Chem Lett 12: 799-802 (2002)


Article DOI: 10.1016/s0960-894x(02)00018-5
BindingDB Entry DOI: 10.7270/Q2M044R7
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50110416
PNG
(CHEMBL350620 | FR-226928 | Naphthalene-1-sulfonic ...)
Show SMILES COc1ccc2CCCC(CNCC3CCN(CCNS(=O)(=O)c4cccc5ccccc45)CC3)Cc2c1
Show InChI InChI=1S/C31H41N3O3S/c1-37-29-13-12-26-8-4-6-25(20-28(26)21-29)23-32-22-24-14-17-34(18-15-24)19-16-33-38(35,36)31-11-5-9-27-7-2-3-10-30(27)31/h2-3,5,7,9-13,21,24-25,32-33H,4,6,8,14-20,22-23H2,1H3
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n/an/a 16n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of 125 I-PYY binding to human Neuropeptide Y receptor type 5


Bioorg Med Chem Lett 12: 799-802 (2002)


Article DOI: 10.1016/s0960-894x(02)00018-5
BindingDB Entry DOI: 10.7270/Q2M044R7
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50110570
PNG
(CHEMBL166399 | Naphthalene-1-sulfonic acid [2-(4-{...)
Show SMILES COc1ccc2CCCC(O)(CNCCC3CCN(CCNS(=O)(=O)c4cccc5ccccc45)CC3)c2c1
Show InChI InChI=1S/C31H41N3O4S/c1-38-27-12-11-26-8-5-16-31(35,29(26)22-27)23-32-17-13-24-14-19-34(20-15-24)21-18-33-39(36,37)30-10-4-7-25-6-2-3-9-28(25)30/h2-4,6-7,9-12,22,24,32-33,35H,5,8,13-21,23H2,1H3
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n/an/a 24n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of 125 I-PYY binding to human Neuropeptide Y receptor type 5


Bioorg Med Chem Lett 12: 799-802 (2002)


Article DOI: 10.1016/s0960-894x(02)00018-5
BindingDB Entry DOI: 10.7270/Q2M044R7
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50110564
PNG
(5-Chloro-3-[2-(4-{[(1-hydroxy-7-methoxy-1,2,3,4-te...)
Show SMILES COc1ccc2CCCC(O)(CNCC3CCN(CC3)C(=O)Cn3c4cc(Cl)ccc4sc3=O)c2c1
Show InChI InChI=1S/C27H32ClN3O4S/c1-35-21-6-4-19-3-2-10-27(34,22(19)14-21)17-29-15-18-8-11-30(12-9-18)25(32)16-31-23-13-20(28)5-7-24(23)36-26(31)33/h4-7,13-14,18,29,34H,2-3,8-12,15-17H2,1H3
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n/an/a 28n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of 125 I-PYY binding to human Neuropeptide Y receptor type 5


Bioorg Med Chem Lett 12: 799-802 (2002)


Article DOI: 10.1016/s0960-894x(02)00018-5
BindingDB Entry DOI: 10.7270/Q2M044R7
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50110568
PNG
(1-[2-(5-Chloro-2-oxo-benzothiazol-3-yl)-acetyl]-pi...)
Show SMILES Clc1ccc2sc(=O)n(CC(=O)N3CCC(CC3)C(=O)Nc3nccs3)c2c1
Show InChI InChI=1S/C18H17ClN4O3S2/c19-12-1-2-14-13(9-12)23(18(26)28-14)10-15(24)22-6-3-11(4-7-22)16(25)21-17-20-5-8-27-17/h1-2,5,8-9,11H,3-4,6-7,10H2,(H,20,21,25)
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n/an/a 53n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of 125 I-PYY binding to human Neuropeptide Y receptor type 5


Bioorg Med Chem Lett 12: 799-802 (2002)


Article DOI: 10.1016/s0960-894x(02)00018-5
BindingDB Entry DOI: 10.7270/Q2M044R7
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50110566
PNG
(CHEMBL167621 | Naphthalene-1-sulfonic acid [2-(4-{...)
Show SMILES COc1ccc2CCCC(O)(CNCC3CCN(CCNS(=O)(=O)c4cccc5ccccc45)CC3)Cc2c1
Show InChI InChI=1S/C31H41N3O4S/c1-38-28-12-11-25-8-5-15-31(35,21-27(25)20-28)23-32-22-24-13-17-34(18-14-24)19-16-33-39(36,37)30-10-4-7-26-6-2-3-9-29(26)30/h2-4,6-7,9-12,20,24,32-33,35H,5,8,13-19,21-23H2,1H3
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n/an/a 56n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of 125 I-PYY binding to human Neuropeptide Y receptor type 5


Bioorg Med Chem Lett 12: 799-802 (2002)


Article DOI: 10.1016/s0960-894x(02)00018-5
BindingDB Entry DOI: 10.7270/Q2M044R7
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50110563
PNG
(CHEMBL354111 | Naphthalene-1-sulfonic acid [2-(4-{...)
Show SMILES COc1ccc2CCC(O)(CNCC3CCN(CCNS(=O)(=O)c4cccc5ccccc45)CC3)c2c1
Show InChI InChI=1S/C29H37N3O4S/c1-36-25-10-9-24-11-14-29(33,27(24)19-25)21-30-20-22-12-16-32(17-13-22)18-15-31-37(34,35)28-8-4-6-23-5-2-3-7-26(23)28/h2-10,19,22,30-31,33H,11-18,20-21H2,1H3
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n/an/a 66n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of 125 I-PYY binding to human Neuropeptide Y receptor type 5


Bioorg Med Chem Lett 12: 799-802 (2002)


Article DOI: 10.1016/s0960-894x(02)00018-5
BindingDB Entry DOI: 10.7270/Q2M044R7
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50110416
PNG
(CHEMBL350620 | FR-226928 | Naphthalene-1-sulfonic ...)
Show SMILES COc1ccc2CCCC(CNCC3CCN(CCNS(=O)(=O)c4cccc5ccccc45)CC3)Cc2c1
Show InChI InChI=1S/C31H41N3O3S/c1-37-29-13-12-26-8-4-6-25(20-28(26)21-29)23-32-22-24-14-17-34(18-15-24)19-16-33-38(35,36)31-11-5-9-27-7-2-3-10-30(27)31/h2-3,5,7,9-13,21,24-25,32-33H,4,6,8,14-20,22-23H2,1H3
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n/an/a 9.50E+3n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against human Neuropeptide Y receptor type 1


Bioorg Med Chem Lett 12: 799-802 (2002)


Article DOI: 10.1016/s0960-894x(02)00018-5
BindingDB Entry DOI: 10.7270/Q2M044R7
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50110562
PNG
(5-Chloro-3-(2-{4-[(3-methoxy-6,7,8,9-tetrahydro-5H...)
Show SMILES COc1ccc2CCCC(Cc2c1)NCC1CCN(CC1)C(=O)Cn1c2cc(Cl)ccc2sc1=O
Show InChI InChI=1S/C27H32ClN3O3S/c1-34-23-7-5-19-3-2-4-22(13-20(19)14-23)29-16-18-9-11-30(12-10-18)26(32)17-31-24-15-21(28)6-8-25(24)35-27(31)33/h5-8,14-15,18,22,29H,2-4,9-13,16-17H2,1H3
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n/an/a 1.20E+4n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against human Neuropeptide Y receptor type 1


Bioorg Med Chem Lett 12: 799-802 (2002)


Article DOI: 10.1016/s0960-894x(02)00018-5
BindingDB Entry DOI: 10.7270/Q2M044R7
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%