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Found 8 Enz. Inhib. hit(s) with all data for entry = 50012220
TargetGlutamate carboxypeptidase 2(Rattus norvegicus)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116251(2-{[3-(4-Amino-benzoylamino)-3-carboxy-propyl]-hyd...)
Affinity DataIC50:  3nMAssay Description:Compound was evaluated for its ability to inhibit Glutamate carboxypeptidase-II using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Rattus norvegicus)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116253(2-{[3-Carboxy-3-(4-methylamino-benzoylamino)-propy...)
Affinity DataIC50:  4nMAssay Description:Compound was evaluated for its ability to inhibit Glutamate carboxypeptidase-II using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Rattus norvegicus)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116250(2-[(3-Carboxy-3-{4-[(2,4-diamino-pteridin-6-ylmeth...)
Affinity DataIC50:  4nMAssay Description:Compound was evaluated for its ability to inhibit Glutamate carboxypeptidase-II using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Rattus norvegicus)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116252(2-[(3-Carboxy-3-{4-[(2,4-diamino-pteridin-6-ylmeth...)
Affinity DataIC50:  5nMAssay Description:Compound was evaluated for its ability to inhibit Glutamate carboxypeptidase-II using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116252(2-[(3-Carboxy-3-{4-[(2,4-diamino-pteridin-6-ylmeth...)
Affinity DataIC50:  20nMAssay Description:Compound was evaluated for its ability to inhibit Folylpoly-gamma-glutamyl synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116250(2-[(3-Carboxy-3-{4-[(2,4-diamino-pteridin-6-ylmeth...)
Affinity DataIC50:  120nMAssay Description:Compound was evaluated for its ability to inhibit Folylpoly-gamma-glutamyl synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116253(2-{[3-Carboxy-3-(4-methylamino-benzoylamino)-propy...)
Affinity DataIC50:  5.70E+3nMAssay Description:Compound was evaluated for its ability to inhibit Folylpoly-gamma-glutamyl synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116251(2-{[3-(4-Amino-benzoylamino)-3-carboxy-propyl]-hyd...)
Affinity DataIC50:  8.60E+3nMAssay Description:Compound was evaluated for its ability to inhibit Folylpoly-gamma-glutamyl synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed