BindingDB PrimarySearch

Found 26 Enz. Inhib. hit(s) with all data for entry = 50013031

Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM50125662((S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]-4-meth...)

IC50: 160nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

BDBM50125656((S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]-4-meth...)

IC50: 180nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

BDBM50125670((S)-4-Methyl-2-(4-methyl-pentanoylamino)-pentanoic...)

IC50: 300nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

BDBM50125653((S)-4-Methyl-2-phenylacetylamino-pentanoic acid ((...)

IC50: 400nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

BDBM50125658((S)-2-[2-(3-Fluoro-phenyl)-acetylamino]-4-methyl-p...)

IC50: 400nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

BDBM50125657((2R,3S)-4-Cyclohexyl-3-{(S)-2-[2-(3,5-difluoro-phe...)

IC50: 450nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

BDBM50125666((S)-4-Methyl-2-(4-methyl-pentanoylamino)-pentanoic...)

IC50: 550nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

BDBM50125659((S)-4-Methyl-2-(4-methyl-pentanoylamino)-pentanoic...)

IC50: 580nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

BDBM50125677((S)-4-Methyl-2-phenylacetylamino-pentanoic acid ((...)

IC50: 600nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

BDBM50125675((S)-4-Methyl-2-(4-methyl-pentanoylamino)-pentanoic...)

IC50: 620nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

BDBM50125672((S)-4-Methyl-2-phenylacetylamino-pentanoic acid ((...)

IC50: 900nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

BDBM50125664((S)-4-Methyl-2-phenylacetylamino-pentanoic acid ((...)

IC50: 900nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

BDBM50125654((2R,3S)-4-Cyclohexyl-3-{(S)-2-[2-(3-fluoro-phenyl)...)

IC50: 920nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

BDBM50125669((2R,3S)-4-Cyclohexyl-2-hydroxy-3-[(S)-4-methyl-2-(...)

IC50: 1.50E+3nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

BDBM50125668((2R,3S)-4-Cyclohexyl-2-hydroxy-3-((S)-4-methyl-2-p...)

IC50: 1.60E+3nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

BDBM50125671((2R,3S)-4-Cyclohexyl-3-{(S)-2-[2-(4-fluoro-phenyl)...)

IC50: 1.80E+3nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

BDBM50125655((2R,3S)-4-Cyclohexyl-2-hydroxy-3-[(S)-3-methyl-2-(...)

IC50: 3.30E+3nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

BDBM50125674((2R,3S)-4-Cyclohexyl-2-hydroxy-3-((S)-3-methyl-2-p...)

IC50: 3.40E+3nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

BDBM50125652((S)-4-Methyl-2-(4-methyl-pentanoylamino)-pentanoic...)

IC50: 4.50E+3nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

BDBM50125673((2R,3S)-4-Cyclohexyl-2-hydroxy-3-{(S)-3-methyl-2-[...)

IC50: 5.00E+3nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

BDBM50125665((2R,3S)-4-Cyclohexyl-2-hydroxy-3-((S)-3-phenyl-2-p...)

IC50: 1.50E+4nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

BDBM50125661((2R,3S)-4-Cyclohexyl-2-hydroxy-3-((S)-4-methyl-2-p...)

IC50: 1.50E+4nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

CHEMBL KEGG PC cid PC sid Similars

Details Article PubMed

BDBM50125663((2R,3S)-4-Cyclohexyl-3-{(S)-2-[2-(2-fluoro-phenyl)...)

IC50: 1.70E+4nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

BDBM50125660((2R,3S)-3-((S)-2-Benzoylamino-3-methyl-butyrylamin...)

IC50: >2.50E+4nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

BDBM50125667((2R,3S)-4-Cyclohexyl-2-hydroxy-3-{(S)-3-methyl-2-[...)

IC50: >2.50E+4nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

BDBM50125676((2R,3S)-4-Cyclohexyl-2-hydroxy-3-((R)-3-methyl-2-p...)

IC50: >2.50E+4nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed