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Found 46 Enz. Inhib. hit(s) with all data for entry = 50013627
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132647(1-(3,3-Diphenyl-propyl)-4-(3-trifluoromethyl-pheny...)
Affinity DataKi:  1nMAssay Description:Antagonistic activity against opioid receptor mu1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132644(4-(4-Chloro-3-trifluoromethyl-phenyl)-1-(3,3-diphe...)
Affinity DataKi:  4nMAssay Description:Antagonistic activity against opioid receptor mu1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132645(4-(4-Chloro-3-trifluoromethyl-phenyl)-1-(4-isoprop...)
Affinity DataKi:  8nMAssay Description:Antagonistic activity against opioid receptor mu1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132650(1-(Decahydro-naphthalen-2-yl)-4-(3-trifluoromethyl...)
Affinity DataKi:  12nMAssay Description:Antagonistic activity against orphan FQ receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132639(1-(4-Isopropyl-cyclohexyl)-4-(3-trifluoromethyl-ph...)
Affinity DataKi:  12nMAssay Description:Antagonistic activity against orphan FQ receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132641(4-(4-Chloro-3-trifluoromethyl-phenyl)-1-indan-2-yl...)
Affinity DataKi:  19nMAssay Description:Antagonistic activity against opioid receptor mu1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132650(1-(Decahydro-naphthalen-2-yl)-4-(3-trifluoromethyl...)
Affinity DataKi:  21nMAssay Description:Antagonistic activity against opioid receptor mu1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132645(4-(4-Chloro-3-trifluoromethyl-phenyl)-1-(4-isoprop...)
Affinity DataKi:  33nMAssay Description:Antagonistic activity against orphan FQ receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132639(1-(4-Isopropyl-cyclohexyl)-4-(3-trifluoromethyl-ph...)
Affinity DataKi:  36nMAssay Description:Antagonistic activity against opioid receptor mu1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132642(1-(4-Propyl-cyclohexyl)-4-(3-trifluoromethyl-pheny...)
Affinity DataKi:  46nMAssay Description:Antagonistic activity against opioid receptor mu1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132643(4-(4-Chloro-3-trifluoromethyl-phenyl)-1-cyclooctyl...)
Affinity DataKi:  47nMAssay Description:Antagonistic activity against orphan FQ receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132641(4-(4-Chloro-3-trifluoromethyl-phenyl)-1-indan-2-yl...)
Affinity DataKi:  82nMAssay Description:Antagonistic activity against orphan FQ receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132652(1-Cyclooctylmethyl-4-(3-trifluoromethyl-phenyl)-pi...)
Affinity DataKi:  102nMAssay Description:Antagonistic activity against orphan FQ receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132652(1-Cyclooctylmethyl-4-(3-trifluoromethyl-phenyl)-pi...)
Affinity DataKi:  113nMAssay Description:Antagonistic activity against opioid receptor mu1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132647(1-(3,3-Diphenyl-propyl)-4-(3-trifluoromethyl-pheny...)
Affinity DataKi:  116nMAssay Description:Antagonistic activity against orphan FQ receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132643(4-(4-Chloro-3-trifluoromethyl-phenyl)-1-cyclooctyl...)
Affinity DataKi:  124nMAssay Description:Antagonistic activity against opioid receptor mu1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132642(1-(4-Propyl-cyclohexyl)-4-(3-trifluoromethyl-pheny...)
Affinity DataKi:  135nMAssay Description:Antagonistic activity against orphan FQ receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132654(4-(4-Chloro-phenyl)-1-naphthalen-2-ylmethyl-piperi...)
Affinity DataKi:  153nMAssay Description:Binding affinity against human orphanin FQ receptor expressed in recombinant HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132644(4-(4-Chloro-3-trifluoromethyl-phenyl)-1-(3,3-diphe...)
Affinity DataKi:  225nMAssay Description:Antagonistic activity against orphan FQ receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132658(4-(4-Chloro-3-trifluoromethyl-phenyl)-1-(4-fluoro-...)
Affinity DataKi:  234nMAssay Description:Binding affinity against human orphanin FQ receptor expressed in recombinant HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132655(4-(4-Chloro-phenyl)-1-(4-trifluoromethyl-benzyl)-p...)
Affinity DataKi:  307nMAssay Description:Binding affinity against human orphanin FQ receptor expressed in recombinant HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132648(4-(4-Chloro-phenyl)-1-cyclooctylmethyl-piperidin-4...)
Affinity DataKi:  502nMAssay Description:Antagonistic activity against orphan FQ receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132648(4-(4-Chloro-phenyl)-1-cyclooctylmethyl-piperidin-4...)
Affinity DataKi:  626nMAssay Description:Antagonistic activity against opioid receptor mu1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132646(1-(4-Fluoro-benzyl)-4-(3-trifluoromethyl-phenyl)-p...)
Affinity DataKi:  692nMAssay Description:Binding affinity against human orphanin FQ receptor expressed in recombinant HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132664(1-Naphthalen-2-ylmethyl-4-(3-trifluoromethyl-pheny...)
Affinity DataKi:  715nMAssay Description:Binding affinity against human orphanin FQ receptor expressed in recombinant HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132663(1-Naphthalen-1-ylmethyl-4-phenyl-piperidine-4-carb...)
Affinity DataKi:  827nMAssay Description:Binding affinity against human orphanin FQ receptor expressed in recombinant HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132662(4-(4-Chloro-3-trifluoromethyl-phenyl)-1-naphthalen...)
Affinity DataKi:  879nMAssay Description:Binding affinity against human orphanin FQ receptor expressed in recombinant HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132656(1-Naphthalen-2-ylmethyl-4-phenyl-piperidine-4-carb...)
Affinity DataKi:  1.11E+3nMAssay Description:Binding affinity against human orphanin FQ receptor expressed in recombinant HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132651(4-(4-Chloro-3-trifluoromethyl-phenyl)-1-(4-trifluo...)
Affinity DataKi:  1.19E+3nMAssay Description:Binding affinity against human orphanin FQ receptor expressed in recombinant HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132659(1-(3,4-Dichloro-benzyl)-4-phenyl-piperidine-4-carb...)
Affinity DataKi:  1.27E+3nMAssay Description:Binding affinity against human orphanin FQ receptor expressed in recombinant HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132643(4-(4-Chloro-3-trifluoromethyl-phenyl)-1-cyclooctyl...)
Affinity DataKi:  1.65E+3nMAssay Description:Antagonistic activity of the compound against opioid receptor kappa 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132639(1-(4-Isopropyl-cyclohexyl)-4-(3-trifluoromethyl-ph...)
Affinity DataKi:  4.15E+3nMAssay Description:Antagonistic activity of the compound against opioid receptor kappa 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132652(1-Cyclooctylmethyl-4-(3-trifluoromethyl-phenyl)-pi...)
Affinity DataKi:  4.24E+3nMAssay Description:Antagonistic activity of the compound against opioid receptor kappa 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132639(1-(4-Isopropyl-cyclohexyl)-4-(3-trifluoromethyl-ph...)
Affinity DataKi:  5.67E+3nMAssay Description:Antagonistic activity against Opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132642(1-(4-Propyl-cyclohexyl)-4-(3-trifluoromethyl-pheny...)
Affinity DataKi:  6.00E+3nMAssay Description:Antagonistic activity of the compound against opioid receptor kappa 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132660(1-(4-Trifluoromethyl-benzyl)-4-(3-trifluoromethyl-...)
Affinity DataKi:  6.52E+3nMAssay Description:Binding affinity against human orphanin FQ receptor expressed in recombinant HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132643(4-(4-Chloro-3-trifluoromethyl-phenyl)-1-cyclooctyl...)
Affinity DataKi:  8.78E+3nMAssay Description:Antagonistic activity against Opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132647(1-(3,3-Diphenyl-propyl)-4-(3-trifluoromethyl-pheny...)
Affinity DataKi:  9.39E+3nMAssay Description:Antagonistic activity against Opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132649(1-(4-Fluoro-benzyl)-4-phenyl-piperidine-4-carbonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity against human orphanin FQ receptor expressed in recombinant HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132645(4-(4-Chloro-3-trifluoromethyl-phenyl)-1-(4-isoprop...)
Affinity DataKi:  1.00E+4nMAssay Description:Antagonistic activity against Opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132650(1-(Decahydro-naphthalen-2-yl)-4-(3-trifluoromethyl...)
Affinity DataKi:  1.00E+4nMAssay Description:Antagonistic activity against Opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132641(4-(4-Chloro-3-trifluoromethyl-phenyl)-1-indan-2-yl...)
Affinity DataKi:  1.00E+4nMAssay Description:Antagonistic activity against Opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132653(4-[4-(4-Chloro-3-trifluoromethyl-phenyl)-4-hydroxy...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity against human orphanin FQ receptor expressed in recombinant HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132640(2-Benzyloxy-1-[4-(4-bromo-phenyl)-4-hydroxy-piperi...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity against human orphanin FQ receptor expressed in recombinant HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132657(4-(4-Chloro-3-trifluoromethyl-phenyl)-1-(5-nitro-f...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity against human orphanin FQ receptor expressed in recombinant HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50132661(1-(2-Methyl-naphthalen-1-ylmethyl)-4-phenyl-piperi...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity against human orphanin FQ receptor expressed in recombinant HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed