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PubMed code 1336055

Compile data set for download or QSAR
Found 22 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50230226
PNG
(CHEMBL144015)
Show SMILES CCc1nccc2nc(O)ccc12
Show InChI InChI=1S/C10H10N2O/c1-2-8-7-3-4-10(13)12-9(7)5-6-11-8/h3-6H,2H2,1H3,(H,12,13)
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n/an/a 40n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cAMP PDE III.


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50230281
PNG
(CHEMBL144682)
Show SMILES CCCc1nccc2nc(O)ccc12
Show InChI InChI=1S/C11H12N2O/c1-2-3-9-8-4-5-11(14)13-10(8)6-7-12-9/h4-7H,2-3H2,1H3,(H,13,14)
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n/an/a 48n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cAMP PDE III.


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50230235
PNG
(CHEMBL144395)
Show SMILES Oc1ccc2c(nccc2n1)-c1ccco1
Show InChI InChI=1S/C12H8N2O2/c15-11-4-3-8-9(14-11)5-6-13-12(8)10-2-1-7-16-10/h1-7H,(H,14,15)
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n/an/a 140n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cAMP PDE III.


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50230227
PNG
(CHEMBL356549)
Show SMILES Oc1ccc2c(nccc2n1)-c1cccs1
Show InChI InChI=1S/C12H8N2OS/c15-11-4-3-8-9(14-11)5-6-13-12(8)10-2-1-7-16-10/h1-7H,(H,14,15)
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n/an/a 140n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cAMP PDE III.


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50230228
PNG
(CHEMBL144154)
Show SMILES Oc1ccc2c(nccc2n1)C(Cl)Cl
Show InChI InChI=1S/C9H6Cl2N2O/c10-9(11)8-5-1-2-7(14)13-6(5)3-4-12-8/h1-4,9H,(H,13,14)
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n/an/a 160n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE 3


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50230229
PNG
(CHEMBL144190)
Show SMILES Oc1ccc2c(Br)nccc2n1
Show InChI InChI=1S/C8H5BrN2O/c9-8-5-1-2-7(12)11-6(5)3-4-10-8/h1-4H,(H,11,12)
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n/an/a 170n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE 3


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50230225
PNG
(CHEMBL144713)
Show SMILES Nc1ccc(cc1)-c1nccc2nc(O)ccc12
Show InChI InChI=1S/C14H11N3O/c15-10-3-1-9(2-4-10)14-11-5-6-13(18)17-12(11)7-8-16-14/h1-8H,15H2,(H,17,18)
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n/an/a 230n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cAMP PDE III.


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50230231
PNG
(CHEMBL556516)
Show SMILES Oc1ccc2c(nccc2n1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C14H9ClN2O/c15-10-3-1-9(2-4-10)14-11-5-6-13(18)17-12(11)7-8-16-14/h1-8H,(H,17,18)
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n/an/a 300n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cAMP PDE III.


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM15296
PNG
(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N
Show InChI InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
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n/an/a 360n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of cAMP Phosphodiesterase 3


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50230222
PNG
(MEDORINONE | Medorinone | WIN-49016)
Show SMILES Cc1nccc2nc(O)ccc12
Show InChI InChI=1S/C9H8N2O/c1-6-7-2-3-9(12)11-8(7)4-5-10-6/h2-5H,1H3,(H,11,12)
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n/an/a 550n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE 3


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50230237
PNG
(CHEMBL357234)
Show SMILES CC(C)Cc1nccc2nc(O)ccc12
Show InChI InChI=1S/C12H14N2O/c1-8(2)7-11-9-3-4-12(15)14-10(9)5-6-13-11/h3-6,8H,7H2,1-2H3,(H,14,15)
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n/an/a 570n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cAMP PDE III.


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50230238
PNG
(CHEMBL356805)
Show SMILES Oc1ccc(cc1)-c1nccc2nc(O)ccc12
Show InChI InChI=1S/C14H10N2O2/c17-10-3-1-9(2-4-10)14-11-5-6-13(18)16-12(11)7-8-15-14/h1-8,17H,(H,16,18)
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n/an/a 600n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of cAMP Phosphodiesterase 3


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50230223
PNG
(CHEMBL144453)
Show SMILES Oc1ccc2c(nccc2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C14H9FN2O/c15-10-3-1-9(2-4-10)14-11-5-6-13(18)17-12(11)7-8-16-14/h1-8H,(H,17,18)
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n/an/a 940n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cAMP PDE III.


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50230279
PNG
(CHEMBL144706)
Show SMILES Cc1nccc2nc(S)ccc12
Show InChI InChI=1S/C9H8N2S/c1-6-7-2-3-9(12)11-8(7)4-5-10-6/h2-5H,1H3,(H,11,12)
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n/an/a 960n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of cAMP Phosphodiesterase 3


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50230239
PNG
(CHEMBL343895)
Show SMILES Oc1ccc2c(nccc2n1)-c1ccccc1
Show InChI InChI=1S/C14H10N2O/c17-13-7-6-11-12(16-13)8-9-15-14(11)10-4-2-1-3-5-10/h1-9H,(H,16,17)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cAMP PDE III.


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50230232
PNG
(CHEMBL145429)
Show SMILES CC(=O)c1nccc2nc(O)ccc12
Show InChI InChI=1S/C10H8N2O2/c1-6(13)10-7-2-3-9(14)12-8(7)4-5-11-10/h2-5H,1H3,(H,12,14)
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n/an/a 1.42E+3n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cAMP PDE III.


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50230224
PNG
(CHEMBL147736)
Show SMILES Oc1ccc2c(nccc2n1)-c1ccncc1
Show InChI InChI=1S/C13H9N3O/c17-12-2-1-10-11(16-12)5-8-15-13(10)9-3-6-14-7-4-9/h1-8H,(H,16,17)
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n/an/a 2.20E+3n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cAMP PDE III.


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50230280
PNG
(CHEMBL142834)
Show SMILES Cc1cn(cn1)-c1nccc2nc(O)ccc12
Show InChI InChI=1S/C12H10N4O/c1-8-6-16(7-14-8)12-9-2-3-11(17)15-10(9)4-5-13-12/h2-7H,1H3,(H,15,17)
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n/an/a 2.80E+3n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cAMP PDE III.


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50230236
PNG
(CHEMBL2112000)
Show SMILES Cc1[n+]([O-])ccc2[nH]c(=O)ccc12
Show InChI InChI=1S/C9H8N2O2/c1-6-7-2-3-9(12)10-8(7)4-5-11(6)13/h2-5H,1H3,(H,10,12)
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n/an/a 3.10E+3n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cAMP PDE III.


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50230234
PNG
(CHEMBL356143)
Show SMILES COc1ccc(cc1)-c1nccc2nc(O)ccc12
Show InChI InChI=1S/C15H12N2O2/c1-19-11-4-2-10(3-5-11)15-12-6-7-14(18)17-13(12)8-9-16-15/h2-9H,1H3,(H,17,18)
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n/an/a 3.20E+3n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cAMP PDE III.


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50230233
PNG
(CHEMBL145024)
Show SMILES OCc1nccc2nc(O)ccc12
Show InChI InChI=1S/C9H8N2O2/c12-5-8-6-1-2-9(13)11-7(6)3-4-10-8/h1-4,12H,5H2,(H,11,13)
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n/an/a 3.70E+3n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cAMP PDE III.


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50230230
PNG
(CHEMBL422303)
Show SMILES Oc1ccc2cnccc2n1
Show InChI InChI=1S/C8H6N2O/c11-8-2-1-6-5-9-4-3-7(6)10-8/h1-5H,(H,10,11)
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n/an/a 1.88E+4n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cAMP PDE III.


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%