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PubMed code 1352351

Compile data set for download or QSAR
Found 32 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406648
PNG
(CHEMBL82654)
Show SMILES CC(C)NC(=O)NCCCOc1cccc(CN2CCCCC2)c1
Show InChI InChI=1S/C19H31N3O2/c1-16(2)21-19(23)20-10-7-13-24-18-9-6-8-17(14-18)15-22-11-4-3-5-12-22/h6,8-9,14,16H,3-5,7,10-13,15H2,1-2H3,(H2,20,21,23)
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n/an/an/a 43.6n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


J Med Chem 35: 2446-51 (1992)


Article DOI: 10.1021/jm00091a012
BindingDB Entry DOI: 10.7270/Q2V9898T
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406663
PNG
(CHEMBL80069)
Show SMILES FC(F)(F)c1cccc(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)c1
Show InChI InChI=1S/C23H28F3N3O2/c24-23(25,26)19-8-5-9-20(16-19)28-22(30)27-11-6-14-31-21-10-4-7-18(15-21)17-29-12-2-1-3-13-29/h4-5,7-10,15-16H,1-3,6,11-14,17H2,(H2,27,28,30)
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n/an/an/a 813n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


J Med Chem 35: 2446-51 (1992)


Article DOI: 10.1021/jm00091a012
BindingDB Entry DOI: 10.7270/Q2V9898T
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406659
PNG
(CHEMBL78339)
Show SMILES FCCNC(=O)NCCCOc1cccc(CN2CCCCC2)c1
Show InChI InChI=1S/C18H28FN3O2/c19-8-10-21-18(23)20-9-5-13-24-17-7-4-6-16(14-17)15-22-11-2-1-3-12-22/h4,6-7,14H,1-3,5,8-13,15H2,(H2,20,21,23)
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n/an/an/a 85.1n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


J Med Chem 35: 2446-51 (1992)


Article DOI: 10.1021/jm00091a012
BindingDB Entry DOI: 10.7270/Q2V9898T
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406665
PNG
(CHEMBL79507)
Show SMILES COc1ccc(NC(=S)NCCCOc2cccc(CN3CCCCC3)c2)cc1
Show InChI InChI=1S/C23H31N3O2S/c1-27-21-11-9-20(10-12-21)25-23(29)24-13-6-16-28-22-8-5-7-19(17-22)18-26-14-3-2-4-15-26/h5,7-12,17H,2-4,6,13-16,18H2,1H3,(H2,24,25,29)
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n/an/an/a 4.37E+3n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


J Med Chem 35: 2446-51 (1992)


Article DOI: 10.1021/jm00091a012
BindingDB Entry DOI: 10.7270/Q2V9898T
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406667
PNG
(CHEMBL80105)
Show SMILES O=C(NCCCOc1cccc(CN2CCCCC2)c1)NCc1ccccc1
Show InChI InChI=1S/C23H31N3O2/c27-23(25-18-20-9-3-1-4-10-20)24-13-8-16-28-22-12-7-11-21(17-22)19-26-14-5-2-6-15-26/h1,3-4,7,9-12,17H,2,5-6,8,13-16,18-19H2,(H2,24,25,27)
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n/an/an/a 347n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


J Med Chem 35: 2446-51 (1992)


Article DOI: 10.1021/jm00091a012
BindingDB Entry DOI: 10.7270/Q2V9898T
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50036754
PNG
((1Z)-N'-(aminosulfonyl)-3-[({2-[(diaminomethylene)...)
Show SMILES NC(N)=Nc1nc(CSCCC(=N)NS(N)(=O)=O)cs1
Show InChI InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)
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n/an/an/a 100n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


J Med Chem 35: 2446-51 (1992)


Article DOI: 10.1021/jm00091a012
BindingDB Entry DOI: 10.7270/Q2V9898T
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406671
PNG
(CHEMBL312419)
Show SMILES COc1ccc(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)cc1
Show InChI InChI=1S/C23H31N3O3/c1-28-21-11-9-20(10-12-21)25-23(27)24-13-6-16-29-22-8-5-7-19(17-22)18-26-14-3-2-4-15-26/h5,7-12,17H,2-4,6,13-16,18H2,1H3,(H2,24,25,27)
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n/an/an/a 631n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


J Med Chem 35: 2446-51 (1992)


Article DOI: 10.1021/jm00091a012
BindingDB Entry DOI: 10.7270/Q2V9898T
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406657
PNG
(CHEMBL309401)
Show SMILES Nc1cccc(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)c1
Show InChI InChI=1S/C22H30N4O2/c23-19-8-5-9-20(16-19)25-22(27)24-11-6-14-28-21-10-4-7-18(15-21)17-26-12-2-1-3-13-26/h4-5,7-10,15-16H,1-3,6,11-14,17,23H2,(H2,24,25,27)
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n/an/an/a 155n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Compound was evaluated in vitro inhibitory activity against histamine H2 receptor in isolated Guinea pig right atria.


J Med Chem 35: 2446-51 (1992)


Article DOI: 10.1021/jm00091a012
BindingDB Entry DOI: 10.7270/Q2V9898T
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406660
PNG
(CHEMBL81545)
Show SMILES O=C(NCCCOc1cccc(CN2CCCCC2)c1)NC1CCCCC1
Show InChI InChI=1S/C22H35N3O2/c26-22(24-20-10-3-1-4-11-20)23-13-8-16-27-21-12-7-9-19(17-21)18-25-14-5-2-6-15-25/h7,9,12,17,20H,1-6,8,10-11,13-16,18H2,(H2,23,24,26)
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n/an/an/a 43.6n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


J Med Chem 35: 2446-51 (1992)


Article DOI: 10.1021/jm00091a012
BindingDB Entry DOI: 10.7270/Q2V9898T
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50403559
PNG
(Brumetadina | CIMETIDINE)
Show SMILES CNC(NCCSCc1[nH]cnc1C)=NC#N
Show InChI InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14)
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n/an/an/a 263n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


J Med Chem 35: 2446-51 (1992)


Article DOI: 10.1021/jm00091a012
BindingDB Entry DOI: 10.7270/Q2V9898T
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406646
PNG
(CHEMBL311272)
Show SMILES Cc1ccc(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)cc1
Show InChI InChI=1S/C23H31N3O2/c1-19-9-11-21(12-10-19)25-23(27)24-13-6-16-28-22-8-5-7-20(17-22)18-26-14-3-2-4-15-26/h5,7-12,17H,2-4,6,13-16,18H2,1H3,(H2,24,25,27)
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n/an/an/a 631n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


J Med Chem 35: 2446-51 (1992)


Article DOI: 10.1021/jm00091a012
BindingDB Entry DOI: 10.7270/Q2V9898T
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406649
PNG
(CHEMBL81758)
Show SMILES O=C(NCCCOc1cccc(CN2CCCCC2)c1)Nc1ccc2OCOc2c1
Show InChI InChI=1S/C23H29N3O4/c27-23(25-19-8-9-21-22(15-19)30-17-29-21)24-10-5-13-28-20-7-4-6-18(14-20)16-26-11-2-1-3-12-26/h4,6-9,14-15H,1-3,5,10-13,16-17H2,(H2,24,25,27)
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n/an/an/a 288n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


J Med Chem 35: 2446-51 (1992)


Article DOI: 10.1021/jm00091a012
BindingDB Entry DOI: 10.7270/Q2V9898T
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406653
PNG
(CHEMBL313060)
Show SMILES COc1ccc(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)c(OC)c1
Show InChI InChI=1S/C24H33N3O4/c1-29-20-10-11-22(23(17-20)30-2)26-24(28)25-12-7-15-31-21-9-6-8-19(16-21)18-27-13-4-3-5-14-27/h6,8-11,16-17H,3-5,7,12-15,18H2,1-2H3,(H2,25,26,28)
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n/an/an/a 2.24E+3n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


J Med Chem 35: 2446-51 (1992)


Article DOI: 10.1021/jm00091a012
BindingDB Entry DOI: 10.7270/Q2V9898T
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM22893
PNG
(CHEMBL512 | Ranitidine | ZANTAC | dimethyl[(5-{[(2...)
Show SMILES CN\C([CH-][N+]([O-])=O)=[NH+]/CCSCc1ccc(CN(C)C)o1
Show InChI InChI=1S/C13H21N4O3S/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3/h4-5,9H,6-8,10H2,1-3H3,(H,14,15)/q-1/p+1
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n/an/an/a 64.6n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Compound was evaluated in vitro inhibitory activity against histamine H2 receptor in isolated Guinea pig right atria.


J Med Chem 35: 2446-51 (1992)


Article DOI: 10.1021/jm00091a012
BindingDB Entry DOI: 10.7270/Q2V9898T
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406655
PNG
(CHEMBL432167)
Show SMILES O=C(NCCCOc1cccc(CN2CCCCC2)c1)NC1CC1
Show InChI InChI=1S/C19H29N3O2/c23-19(21-17-8-9-17)20-10-5-13-24-18-7-4-6-16(14-18)15-22-11-2-1-3-12-22/h4,6-7,14,17H,1-3,5,8-13,15H2,(H2,20,21,23)
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n/an/an/a 47.9n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


J Med Chem 35: 2446-51 (1992)


Article DOI: 10.1021/jm00091a012
BindingDB Entry DOI: 10.7270/Q2V9898T
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406661
PNG
(CHEMBL79974)
Show SMILES CC(C)CNC(=O)NCCCOc1cccc(CN2CCCCC2)c1
Show InChI InChI=1S/C20H33N3O2/c1-17(2)15-22-20(24)21-10-7-13-25-19-9-6-8-18(14-19)16-23-11-4-3-5-12-23/h6,8-9,14,17H,3-5,7,10-13,15-16H2,1-2H3,(H2,21,22,24)
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n/an/an/a 170n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


J Med Chem 35: 2446-51 (1992)


Article DOI: 10.1021/jm00091a012
BindingDB Entry DOI: 10.7270/Q2V9898T
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406666
PNG
(CHEMBL80046)
Show SMILES O=C(NCCCOc1cccc(CN2CCCCC2)c1)Nc1ccccc1
Show InChI InChI=1S/C22H29N3O2/c26-22(24-20-10-3-1-4-11-20)23-13-8-16-27-21-12-7-9-19(17-21)18-25-14-5-2-6-15-25/h1,3-4,7,9-12,17H,2,5-6,8,13-16,18H2,(H2,23,24,26)
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n/an/an/a 126n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


J Med Chem 35: 2446-51 (1992)


Article DOI: 10.1021/jm00091a012
BindingDB Entry DOI: 10.7270/Q2V9898T
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406668
PNG
(CHEMBL81520)
Show SMILES Clc1ccc(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)cc1
Show InChI InChI=1S/C22H28ClN3O2/c23-19-8-10-20(11-9-19)25-22(27)24-12-5-15-28-21-7-4-6-18(16-21)17-26-13-2-1-3-14-26/h4,6-11,16H,1-3,5,12-15,17H2,(H2,24,25,27)
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n/an/an/a 631n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


J Med Chem 35: 2446-51 (1992)


Article DOI: 10.1021/jm00091a012
BindingDB Entry DOI: 10.7270/Q2V9898T
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406651
PNG
(CHEMBL316154)
Show SMILES COc1ccccc1NC(=O)NCCCOc1cccc(CN2CCCCC2)c1
Show InChI InChI=1S/C23H31N3O3/c1-28-22-12-4-3-11-21(22)25-23(27)24-13-8-16-29-20-10-7-9-19(17-20)18-26-14-5-2-6-15-26/h3-4,7,9-12,17H,2,5-6,8,13-16,18H2,1H3,(H2,24,25,27)
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n/an/an/a 776n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


J Med Chem 35: 2446-51 (1992)


Article DOI: 10.1021/jm00091a012
BindingDB Entry DOI: 10.7270/Q2V9898T
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406652
PNG
(CHEMBL311978)
Show SMILES [O-][N+](=O)c1cccc(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)c1
Show InChI InChI=1S/C22H28N4O4/c27-22(24-19-8-5-9-20(16-19)26(28)29)23-11-6-14-30-21-10-4-7-18(15-21)17-25-12-2-1-3-13-25/h4-5,7-10,15-16H,1-3,6,11-14,17H2,(H2,23,24,27)
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n/an/an/a 269n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


J Med Chem 35: 2446-51 (1992)


Article DOI: 10.1021/jm00091a012
BindingDB Entry DOI: 10.7270/Q2V9898T
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406656
PNG
(CHEMBL81039)
Show SMILES COc1ccc(OC)c(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)c1
Show InChI InChI=1S/C24H33N3O4/c1-29-20-10-11-23(30-2)22(17-20)26-24(28)25-12-7-15-31-21-9-6-8-19(16-21)18-27-13-4-3-5-14-27/h6,8-11,16-17H,3-5,7,12-15,18H2,1-2H3,(H2,25,26,28)
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n/an/an/a 158n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


J Med Chem 35: 2446-51 (1992)


Article DOI: 10.1021/jm00091a012
BindingDB Entry DOI: 10.7270/Q2V9898T
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406658
PNG
(CHEMBL81750)
Show SMILES CCC(C)NC(=O)NCCCOc1cccc(CN2CCCCC2)c1
Show InChI InChI=1S/C20H33N3O2/c1-3-17(2)22-20(24)21-11-8-14-25-19-10-7-9-18(15-19)16-23-12-5-4-6-13-23/h7,9-10,15,17H,3-6,8,11-14,16H2,1-2H3,(H2,21,22,24)
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n/an/an/a 95.5n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


J Med Chem 35: 2446-51 (1992)


Article DOI: 10.1021/jm00091a012
BindingDB Entry DOI: 10.7270/Q2V9898T
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406673
PNG
(CHEMBL78519)
Show SMILES CCCCNC(=O)NCCCOc1cccc(CN2CCCCC2)c1
Show InChI InChI=1S/C20H33N3O2/c1-2-3-11-21-20(24)22-12-8-15-25-19-10-7-9-18(16-19)17-23-13-5-4-6-14-23/h7,9-10,16H,2-6,8,11-15,17H2,1H3,(H2,21,22,24)
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n/an/an/a 81.3n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


J Med Chem 35: 2446-51 (1992)


Article DOI: 10.1021/jm00091a012
BindingDB Entry DOI: 10.7270/Q2V9898T
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406647
PNG
(CHEMBL81506)
Show SMILES CNC(=O)NCCCOc1cccc(CN2CCCCC2)c1
Show InChI InChI=1S/C17H27N3O2/c1-18-17(21)19-9-6-12-22-16-8-5-7-15(13-16)14-20-10-3-2-4-11-20/h5,7-8,13H,2-4,6,9-12,14H2,1H3,(H2,18,19,21)
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n/an/an/a 155n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


J Med Chem 35: 2446-51 (1992)


Article DOI: 10.1021/jm00091a012
BindingDB Entry DOI: 10.7270/Q2V9898T
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406672
PNG
(CHEMBL309659)
Show SMILES Clc1cccc(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)c1
Show InChI InChI=1S/C22H28ClN3O2/c23-19-8-5-9-20(16-19)25-22(27)24-11-6-14-28-21-10-4-7-18(15-21)17-26-12-2-1-3-13-26/h4-5,7-10,15-16H,1-3,6,11-14,17H2,(H2,24,25,27)
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n/an/an/a 316n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


J Med Chem 35: 2446-51 (1992)


Article DOI: 10.1021/jm00091a012
BindingDB Entry DOI: 10.7270/Q2V9898T
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406662
PNG
(CHEMBL312601)
Show SMILES FC(F)(F)c1ccc(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)cc1
Show InChI InChI=1S/C23H28F3N3O2/c24-23(25,26)19-8-10-20(11-9-19)28-22(30)27-12-5-15-31-21-7-4-6-18(16-21)17-29-13-2-1-3-14-29/h4,6-11,16H,1-3,5,12-15,17H2,(H2,27,28,30)
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n/an/an/a 1.70E+3n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


J Med Chem 35: 2446-51 (1992)


Article DOI: 10.1021/jm00091a012
BindingDB Entry DOI: 10.7270/Q2V9898T
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406664
PNG
(CHEMBL81859)
Show SMILES [O-][N+](=O)c1ccc(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)cc1
Show InChI InChI=1S/C22H28N4O4/c27-22(24-19-8-10-20(11-9-19)26(28)29)23-12-5-15-30-21-7-4-6-18(16-21)17-25-13-2-1-3-14-25/h4,6-11,16H,1-3,5,12-15,17H2,(H2,23,24,27)
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n/an/an/a 178n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Compound was evaluated in vitro inhibitory activity against histamine H2 receptor in isolated Guinea pig right atria.


J Med Chem 35: 2446-51 (1992)


Article DOI: 10.1021/jm00091a012
BindingDB Entry DOI: 10.7270/Q2V9898T
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406669
PNG
(CHEMBL80084)
Show SMILES COc1cccc(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)c1
Show InChI InChI=1S/C23H31N3O3/c1-28-21-10-6-9-20(17-21)25-23(27)24-12-7-15-29-22-11-5-8-19(16-22)18-26-13-3-2-4-14-26/h5-6,8-11,16-17H,2-4,7,12-15,18H2,1H3,(H2,24,25,27)
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n/an/an/a 200n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


J Med Chem 35: 2446-51 (1992)


Article DOI: 10.1021/jm00091a012
BindingDB Entry DOI: 10.7270/Q2V9898T
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406670
PNG
(DALCOTIDINE)
Show SMILES CCNC(=O)NCCCOc1cccc(CN2CCCCC2)c1
Show InChI InChI=1S/C18H29N3O2/c1-2-19-18(22)20-10-7-13-23-17-9-6-8-16(14-17)15-21-11-4-3-5-12-21/h6,8-9,14H,2-5,7,10-13,15H2,1H3,(H2,19,20,22)
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n/an/an/a 40.7n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


J Med Chem 35: 2446-51 (1992)


Article DOI: 10.1021/jm00091a012
BindingDB Entry DOI: 10.7270/Q2V9898T
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406650
PNG
(CHEMBL82430)
Show SMILES CCOc1ccc(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)cc1
Show InChI InChI=1S/C24H33N3O3/c1-2-29-22-12-10-21(11-13-22)26-24(28)25-14-7-17-30-23-9-6-8-20(18-23)19-27-15-4-3-5-16-27/h6,8-13,18H,2-5,7,14-17,19H2,1H3,(H2,25,26,28)
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n/an/an/a 490n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


J Med Chem 35: 2446-51 (1992)


Article DOI: 10.1021/jm00091a012
BindingDB Entry DOI: 10.7270/Q2V9898T
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406674
PNG
(CHEMBL82599)
Show SMILES CCCNC(=O)NCCCOc1cccc(CN2CCCCC2)c1
Show InChI InChI=1S/C19H31N3O2/c1-2-10-20-19(23)21-11-7-14-24-18-9-6-8-17(15-18)16-22-12-4-3-5-13-22/h6,8-9,15H,2-5,7,10-14,16H2,1H3,(H2,20,21,23)
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n/an/an/a 97.7n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


J Med Chem 35: 2446-51 (1992)


Article DOI: 10.1021/jm00091a012
BindingDB Entry DOI: 10.7270/Q2V9898T
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406654
PNG
(CHEMBL81597)
Show SMILES CC(C)(C)NC(=O)NCCCOc1cccc(CN2CCCCC2)c1
Show InChI InChI=1S/C20H33N3O2/c1-20(2,3)22-19(24)21-11-8-14-25-18-10-7-9-17(15-18)16-23-12-5-4-6-13-23/h7,9-10,15H,4-6,8,11-14,16H2,1-3H3,(H2,21,22,24)
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n/an/an/a 2.09E+3n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


J Med Chem 35: 2446-51 (1992)


Article DOI: 10.1021/jm00091a012
BindingDB Entry DOI: 10.7270/Q2V9898T
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%