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PubMed code 1531365

Compile data set for download or QSAR
Found 7 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM82247
PNG
(8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c1ccccc1
Show InChI InChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m1/s1
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Article
PubMed
0.300n/an/an/an/an/an/an/an/a



University of Lund

Curated by ChEMBL


Assay Description
Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1


J Med Chem 35: 502-7 (1992)


Article DOI: 10.1021/jm00081a010
BindingDB Entry DOI: 10.7270/Q2TH8N95
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50004823
PNG
((6aS,13bR)-11-Chloro-7-methyl-5,6a,7,8,9,13b-hexah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C19H20ClNO/c1-21-9-8-13-10-16(20)18(22)11-15(13)19-14-5-3-2-4-12(14)6-7-17(19)21/h2-5,10-11,17,19,22H,6-9H2,1H3/t17-,19+/m0/s1
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PubMed
1.90n/an/an/an/an/an/an/an/a



University of Lund

Curated by ChEMBL


Assay Description
Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1


J Med Chem 35: 502-7 (1992)


Article DOI: 10.1021/jm00081a010
BindingDB Entry DOI: 10.7270/Q2TH8N95
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50004820
PNG
(3-Chloro-7-methyl-5,6,7,7a,8,12b-hexahydro-7-aza-d...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1Cc1ccccc21
Show InChI InChI=1S/C18H18ClNO/c1-20-7-6-12-8-15(19)17(21)10-14(12)18-13-5-3-2-4-11(13)9-16(18)20/h2-5,8,10,16,18,21H,6-7,9H2,1H3/t16-,18+/m0/s1
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PubMed
7n/an/an/an/an/an/an/an/a



University of Lund

Curated by ChEMBL


Assay Description
Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1


J Med Chem 35: 502-7 (1992)


Article DOI: 10.1021/jm00081a010
BindingDB Entry DOI: 10.7270/Q2TH8N95
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM82248
PNG
(CAS_73445-63-3 | SCH 23388 (S-enantiomer))
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H](C1)c1ccccc1
Show InChI InChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m0/s1
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PubMed
192n/an/an/an/an/an/an/an/a



University of Lund

Curated by ChEMBL


Assay Description
Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1


J Med Chem 35: 502-7 (1992)


Article DOI: 10.1021/jm00081a010
BindingDB Entry DOI: 10.7270/Q2TH8N95
More data for this
Ligand-Target Pair
Adenylate cyclase


(Homo sapiens)
BDBM50230364
PNG
(CHEMBL146629)
Show SMILES Oc1cc2CCNC[C@H](C3CCCCC3)c2cc1O
Show InChI InChI=1S/C16H23NO2/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11/h8-9,11,14,17-19H,1-7,10H2/t14-/m1/s1
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PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



University of Lund

Curated by ChEMBL


Assay Description
Compound was tested for the adenylate cyclase stimulation


J Med Chem 35: 502-7 (1992)


Article DOI: 10.1021/jm00081a010
BindingDB Entry DOI: 10.7270/Q2TH8N95
More data for this
Ligand-Target Pair
Adenylate cyclase


(Homo sapiens)
BDBM50004822
PNG
((R)-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine...)
Show SMILES Oc1cc2CCNC[C@H](c3ccccc3)c2cc1O
Show InChI InChI=1S/C16H17NO2/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11/h1-5,8-9,14,17-19H,6-7,10H2/t14-/m1/s1
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PubMed
n/an/an/an/a 71n/an/an/an/a



University of Lund

Curated by ChEMBL


Assay Description
Compound was tested for the adenylate cyclase stimulation


J Med Chem 35: 502-7 (1992)


Article DOI: 10.1021/jm00081a010
BindingDB Entry DOI: 10.7270/Q2TH8N95
More data for this
Ligand-Target Pair
Adenylate cyclase


(Homo sapiens)
BDBM50004821
PNG
(2,3,4,5-Tetrahydro-1H-benzo[d]azepine-7,8-diol | C...)
Show SMILES Oc1cc2CCNCCc2cc1O
Show InChI InChI=1S/C10H13NO2/c12-9-5-7-1-3-11-4-2-8(7)6-10(9)13/h5-6,11-13H,1-4H2
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PubMed
n/an/an/an/a 5.20E+3n/an/an/an/a



University of Lund

Curated by ChEMBL


Assay Description
Compound was tested for the adenylate cyclase stimulation


J Med Chem 35: 502-7 (1992)


Article DOI: 10.1021/jm00081a010
BindingDB Entry DOI: 10.7270/Q2TH8N95
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%