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PubMed code 1552497

Compile data set for download or QSAR
Found 38 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455940
PNG
(CHEMBL8250)
Show SMILES Cn1cc(C2=NCC3(CCN4CCCC3C4)O2)c2ccccc12
Show InChI InChI=1S/C19H23N3O/c1-21-12-16(15-6-2-3-7-17(15)21)18-20-13-19(23-18)8-10-22-9-4-5-14(19)11-22/h2-3,6-7,12,14H,4-5,8-11,13H2,1H3
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n/an/a 1.10n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for the displacement of [3H]Q-ICS-205-930 from 5-HT3 recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50108392
PNG
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
Show SMILES CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)c1c[nH]c2ccccc12
Show InChI InChI=1S/C17H20N2O2/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16/h2-5,10-13,18H,6-9H2,1H3/t11-,12+,13+
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n/an/a 1.30n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM85330
PNG
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1ccccc1n2C
Show InChI InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3
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n/an/a 1.90n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455933
PNG
(CHEMBL1169549)
Show SMILES Cn1cc(C2=NC[C@@]3(CN4CCC3CC4)O2)c2ccccc12
Show InChI InChI=1S/C18H21N3O/c1-20-10-15(14-4-2-3-5-16(14)20)17-19-11-18(22-17)12-21-8-6-13(18)7-9-21/h2-5,10,13H,6-9,11-12H2,1H3/t18-/m0/s1
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n/an/a 2.60n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for the displacement of [3H]Q-ICS-205-930 from 5-HT3 recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455913
PNG
(CHEMBL1169545)
Show SMILES Cn1cc(C2=NC[C@]3(CN4CCC3CC4)O2)c2ccccc12
Show InChI InChI=1S/C18H21N3O/c1-20-10-15(14-4-2-3-5-16(14)20)17-19-11-18(22-17)12-21-8-6-13(18)7-9-21/h2-5,10,13H,6-9,11-12H2,1H3/t18-/m1/s1
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n/an/a 2.90n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455942
PNG
(CHEMBL7788)
Show SMILES Cn1cc(C2=NC[C@]3(C[N@]4CC[C@@H]3C4)O2)c2ccccc12
Show InChI InChI=1S/C17H19N3O/c1-19-9-14(13-4-2-3-5-15(13)19)16-18-10-17(21-16)11-20-7-6-12(17)8-20/h2-5,9,12H,6-8,10-11H2,1H3/t12-,17-/m1/s1
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n/an/a 3.10n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455920
PNG
(CHEMBL1169546)
Show SMILES Cn1cc(C2=NCC3(CN4CCC3CC4)O2)c2ccccc12
Show InChI InChI=1S/C18H21N3O.2ClH/c1-20-10-15(14-4-2-3-5-16(14)20)17-19-11-18(22-17)12-21-8-6-13(18)7-9-21;;/h2-5,10,13H,6-9,11-12H2,1H3;2*1H
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n/an/a 3.20n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455932
PNG
(CHEMBL8421)
Show SMILES Cn1cc(C2=NCC3(CC4CCC(C3)[N+]4(C)C)O2)c2ccccc12
Show InChI InChI=1S/C20H26N3O.HI/c1-22-12-17(16-6-4-5-7-18(16)22)19-21-13-20(24-19)10-14-8-9-15(11-20)23(14,2)3;/h4-7,12,14-15H,8-11,13H2,1-3H3;1H/q+1;/p-1
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n/an/a 3.30n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455924
PNG
(CHEMBL276728)
Show SMILES Cn1cc(C2=NC[C@@]3(C[N@]4CC[C@@H]3C4)O2)c2ccccc12
Show InChI InChI=1S/C17H19N3O/c1-19-9-14(13-4-2-3-5-15(13)19)16-18-10-17(21-16)11-20-7-6-12(17)8-20/h2-5,9,12H,6-8,10-11H2,1H3/t12-,17+/m1/s1
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n/an/a 3.5n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455918
PNG
(CHEMBL8413)
Show SMILES CN1C2CCC1CC1(CN=C(O1)c1cn(C)c3ccccc13)C2
Show InChI InChI=1S/C19H23N3O/c1-21-11-16(15-5-3-4-6-17(15)21)18-20-12-19(23-18)9-13-7-8-14(10-19)22(13)2/h3-6,11,13-14H,7-10,12H2,1-2H3
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n/an/a 4.60n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455939
PNG
(CHEMBL8615)
Show SMILES C1N=C(OC11CN2CCC1CC2)c1c[nH]c2ccccc12
Show InChI InChI=1S/C17H19N3O/c1-2-4-15-13(3-1)14(9-18-15)16-19-10-17(21-16)11-20-7-5-12(17)6-8-20/h1-4,9,12,18H,5-8,10-11H2
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n/an/a 4.80n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455932
PNG
(CHEMBL8421)
Show SMILES Cn1cc(C2=NCC3(CC4CCC(C3)[N+]4(C)C)O2)c2ccccc12
Show InChI InChI=1S/C20H26N3O.HI/c1-22-12-17(16-6-4-5-7-18(16)22)19-21-13-20(24-19)10-14-8-9-15(11-20)23(14,2)3;/h4-7,12,14-15H,8-11,13H2,1-3H3;1H/q+1;/p-1
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n/an/a 5n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for the displacement of [3H]Q-ICS-205-930 from 5-HT3 recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455915
PNG
(CHEMBL266097)
Show SMILES C#CCn1cc(C2=NCC3(CN4CCC3CC4)O2)c2ccccc12
Show InChI InChI=1S/C20H21N3O/c1-2-9-23-12-17(16-5-3-4-6-18(16)23)19-21-13-20(24-19)14-22-10-7-15(20)8-11-22/h1,3-6,12,15H,7-11,13-14H2
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n/an/a 6.20n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455918
PNG
(CHEMBL8413)
Show SMILES CN1C2CCC1CC1(CN=C(O1)c1cn(C)c3ccccc13)C2
Show InChI InChI=1S/C19H23N3O/c1-21-11-16(15-5-3-4-6-17(15)21)18-20-12-19(23-18)9-13-7-8-14(10-19)22(13)2/h3-6,11,13-14H,7-10,12H2,1-2H3
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n/an/a 6.30n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455914
PNG
(CHEMBL7615)
Show SMILES CC(=O)c1c(C2=NCC3(CN4CCC3CC4)O2)c2ccccc2n1C
Show InChI InChI=1S/C20H23N3O2/c1-13(24)18-17(15-5-3-4-6-16(15)22(18)2)19-21-11-20(25-19)12-23-9-7-14(20)8-10-23/h3-6,14H,7-12H2,1-2H3
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n/an/a 6.5n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455935
PNG
(CHEMBL417239)
Show SMILES C=CCn1cc(C2=NCC3(CN4CCC3CC4)O2)c2ccccc12
Show InChI InChI=1S/C20H23N3O/c1-2-9-23-12-17(16-5-3-4-6-18(16)23)19-21-13-20(24-19)14-22-10-7-15(20)8-11-22/h2-6,12,15H,1,7-11,13-14H2
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n/an/a 7.90n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455922
PNG
(CHEMBL267298)
Show SMILES Cc1cccc2c(cn(C)c12)C1=NCC2(CN3CCC2CC3)O1
Show InChI InChI=1S/C19H23N3O/c1-13-4-3-5-15-16(10-21(2)17(13)15)18-20-11-19(23-18)12-22-8-6-14(19)7-9-22/h3-5,10,14H,6-9,11-12H2,1-2H3
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n/an/a 8.90n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455926
PNG
(CHEMBL1169548)
Show SMILES Cn1cc(C2=NC[C@]3(C[N+]4(C)CCC3CC4)O2)c2ccccc12
Show InChI InChI=1S/C19H24N3O.HI/c1-21-11-16(15-5-3-4-6-17(15)21)18-20-12-19(23-18)13-22(2)9-7-14(19)8-10-22;/h3-6,11,14H,7-10,12-13H2,1-2H3;1H/q+1;/p-1/t14?,19-,22?;/m1./s1
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n/an/a 10n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455919
PNG
(CHEMBL276199)
Show SMILES Cn1cc(C2=NCC3(CC4CCC(C3)N4)O2)c2ccccc12
Show InChI InChI=1S/C18H21N3O/c1-21-10-15(14-4-2-3-5-16(14)21)17-19-11-18(22-17)8-12-6-7-13(9-18)20-12/h2-5,10,12-13,20H,6-9,11H2,1H3
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n/an/a 11n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455930
PNG
(CHEMBL8245)
Show SMILES C(C1CC1)n1cc(C2=NCC3(CN4CCC3CC4)O2)c2ccccc12
Show InChI InChI=1S/C21H25N3O/c1-2-4-19-17(3-1)18(12-24(19)11-15-5-6-15)20-22-13-21(25-20)14-23-9-7-16(21)8-10-23/h1-4,12,15-16H,5-11,13-14H2
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n/an/a 13n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455923
PNG
(CHEMBL429401)
Show SMILES CCn1cc(C2=NCC3(CN4CCC3CC4)O2)c2ccccc12
Show InChI InChI=1S/C19H23N3O/c1-2-22-11-16(15-5-3-4-6-17(15)22)18-20-12-19(23-18)13-21-9-7-14(19)8-10-21/h3-6,11,14H,2,7-10,12-13H2,1H3
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n/an/a 13n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455934
PNG
(CHEMBL268892)
Show SMILES Cn1cc(C2=NCC3(CN4CCC3CC4)O2)c2cc(F)ccc12
Show InChI InChI=1S/C18H20FN3O/c1-21-9-15(14-8-13(19)2-3-16(14)21)17-20-10-18(23-17)11-22-6-4-12(18)5-7-22/h2-3,8-9,12H,4-7,10-11H2,1H3
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n/an/a 15n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM82561
PNG
(CAS_40796-97-2 | TROPANYL 3,5-DICHLOROBENZOATE | T...)
Show SMILES CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C15H17Cl2NO2/c1-18-12-2-3-13(18)8-14(7-12)20-15(19)9-4-10(16)6-11(17)5-9/h4-6,12-14H,2-3,7-8H2,1H3/t12-,13+,14+
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n/an/a 22n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455927
PNG
(CHEMBL274149)
Show SMILES C1N=C(OC11CN2CCC1CC2)c1[nH]nc2ccccc12
Show InChI InChI=1S/C16H18N4O/c1-2-4-13-12(3-1)14(19-18-13)15-17-9-16(21-15)10-20-7-5-11(16)6-8-20/h1-4,11H,5-10H2,(H,18,19)
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n/an/a 26n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455936
PNG
(CHEMBL275517)
Show SMILES Cn1c(I)c(C2=NCC3(CN4CCC3CC4)O2)c2ccccc12
Show InChI InChI=1S/C18H20IN3O/c1-21-14-5-3-2-4-13(14)15(16(21)19)17-20-10-18(23-17)11-22-8-6-12(18)7-9-22/h2-5,12H,6-11H2,1H3
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n/an/a 27n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455941
PNG
(CHEMBL274378)
Show SMILES C1N=C(OC11CN2CCC1CC2)c1csc2ccccc12
Show InChI InChI=1S/C17H18N2OS/c1-2-4-15-13(3-1)14(9-21-15)16-18-10-17(20-16)11-19-7-5-12(17)6-8-19/h1-4,9,12H,5-8,10-11H2
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n/an/a 27n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455944
PNG
(CHEMBL1169544)
Show SMILES Cn1cc(C2=NC[C@@]3(C[N+]4(C)CCC3CC4)O2)c2ccccc12
Show InChI InChI=1S/C19H24N3O.HI/c1-21-11-16(15-5-3-4-6-17(15)21)18-20-12-19(23-18)13-22(2)9-7-14(19)8-10-22;/h3-6,11,14H,7-10,12-13H2,1-2H3;1H/q+1;/p-1/t14?,19-,22?;/m0./s1
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n/an/a 43n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455925
PNG
(CHEMBL267297)
Show SMILES Cc1ccc2n(C)cc(C3=NCC4(CN5CCC4CC5)O3)c2c1
Show InChI InChI=1S/C19H23N3O/c1-13-3-4-17-15(9-13)16(10-21(17)2)18-20-11-19(23-18)12-22-7-5-14(19)6-8-22/h3-4,9-10,14H,5-8,11-12H2,1-2H3
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n/an/a 132n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455929
PNG
(CHEMBL266227)
Show SMILES Cn1c(c(C2=NCC3(CN4CCC3CC4)O2)c2ccccc12)[Si](C)(C)C
Show InChI InChI=1S/C21H29N3OSi/c1-23-17-8-6-5-7-16(17)18(20(23)26(2,3)4)19-22-13-21(25-19)14-24-11-9-15(21)10-12-24/h5-8,15H,9-14H2,1-4H3
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n/an/a 155n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455931
PNG
(CHEMBL267991)
Show SMILES CN1CCC2(CN=C(O2)c2cn(C)c3ccccc23)CC1
Show InChI InChI=1S/C17H21N3O/c1-19-9-7-17(8-10-19)12-18-16(21-17)14-11-20(2)15-6-4-3-5-13(14)15/h3-6,11H,7-10,12H2,1-2H3
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n/an/a 158n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455917
PNG
(CHEMBL268180)
Show SMILES Cn1cc(C2=NCC3(CC4CCC(C3)N4Cc3ccccc3)O2)c2ccccc12
Show InChI InChI=1S/C25H27N3O/c1-27-16-22(21-9-5-6-10-23(21)27)24-26-17-25(29-24)13-19-11-12-20(14-25)28(19)15-18-7-3-2-4-8-18/h2-10,16,19-20H,11-15,17H2,1H3
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n/an/a 174n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for the displacement of [3H]Q-ICS-205-930 from 5-HT3 recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455938
PNG
(CHEMBL8261)
Show SMILES Cn1cc(C2=NCC3(CN4CCC3CC4)O2)c2cc(O)ccc12
Show InChI InChI=1S/C18H21N3O2/c1-20-9-15(14-8-13(22)2-3-16(14)20)17-19-10-18(23-17)11-21-6-4-12(18)5-7-21/h2-3,8-9,12,22H,4-7,10-11H2,1H3
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n/an/a 195n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455943
PNG
(CHEMBL8279)
Show SMILES Cn1cc(C2=NCC3(CN4CCC3CC4)O2)c2cc(ccc12)[N+]([O-])=O
Show InChI InChI=1S/C18H20N4O3/c1-20-9-15(14-8-13(22(23)24)2-3-16(14)20)17-19-10-18(25-17)11-21-6-4-12(18)5-7-21/h2-3,8-9,12H,4-7,10-11H2,1H3
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n/an/a 229n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455937
PNG
(CHEMBL7818)
Show SMILES COc1ccc2n(C)cc(C3=NCC4(CN5CCC4CC5)O3)c2c1
Show InChI InChI=1S/C19H23N3O2/c1-21-10-16(15-9-14(23-2)3-4-17(15)21)18-20-11-19(24-18)12-22-7-5-13(19)6-8-22/h3-4,9-10,13H,5-8,11-12H2,1-2H3
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n/an/a 263n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455916
PNG
(CHEMBL7857)
Show SMILES COc1cccc(c1)C1=NCC2(CN3CCC2CC3)O1
Show InChI InChI=1S/C16H20N2O2/c1-19-14-4-2-3-12(9-14)15-17-10-16(20-15)11-18-7-5-13(16)6-8-18/h2-4,9,13H,5-8,10-11H2,1H3
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n/an/a 407n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455928
PNG
(CHEMBL267076)
Show SMILES Cn1cc(C2=NCC3(CN4CCC3CC4)O2)c2cc(N)ccc12
Show InChI InChI=1S/C18H22N4O/c1-21-9-15(14-8-13(19)2-3-16(14)21)17-20-10-18(23-17)11-22-6-4-12(18)5-7-22/h2-3,8-9,12H,4-7,10-11,19H2,1H3
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n/an/a 575n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50014406
PNG
(2-Me 5-HT | 2-Methyl-5-hydroxytryptamine | 2-methy...)
Show SMILES Cc1[nH]c2ccc(O)cc2c1CCN
Show InChI InChI=1S/C11H14N2O/c1-7-9(4-5-12)10-6-8(14)2-3-11(10)13-7/h2-3,6,13-14H,4-5,12H2,1H3
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n/an/a 646n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455921
PNG
(CHEMBL274094)
Show SMILES Cn1cc(C2=NCC3(C[N+]4([O-])CCC3CC4)O2)c2ccccc12
Show InChI InChI=1S/C18H21N3O2/c1-20-10-15(14-4-2-3-5-16(14)20)17-19-11-18(23-17)12-21(22)8-6-13(18)7-9-21/h2-5,10,13H,6-9,11-12H2,1H3
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n/an/a 2.63E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for the displacement of [3H]Q-ICS-205-930 from 5-HT3 recognition sites in rat brain membranes


J Med Chem 35: 1019-31 (1992)


Article DOI: 10.1021/jm00084a007
BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%