Compile Data Set for Download or QSAR
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Found 9 Enz. Inhib. hit(s) with all data for entry = 50016227
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50166590(4-{3-[4-(2-Methyl-imidazol-1-ylmethyl)-phenylsulfa...)
Affinity DataIC50:  140nMAssay Description:Inhibition of 5-lipoxygenase mediated LTB4 synthesis in A-23187 simulated human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50166593(4-{3-[4-(2-Methyl-imidazol-1-yl)-phenylsulfanyl]-p...)
Affinity DataIC50:  150nMAssay Description:Inhibition of 5-lipoxygenase mediated LTB4 synthesis in A-23187 simulated human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50166596(4-(3-(4-(2-methyl-1H-imidazol-1-yl)phenylthio)phen...)
Affinity DataIC50:  230nMAssay Description:Inhibition of 5-lipoxygenase mediated LTB4 synthesis in A-23187 simulated human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50166595(4-[3-(4-Pyrrol-1-ylmethyl-phenylsulfanyl)-phenyl]-...)
Affinity DataIC50:  270nMAssay Description:Inhibition of 5-lipoxygenase mediated LTB4 synthesis in A-23187 simulated human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50166592((1R,3S)-3-{3-[4-(2-Methyl-imidazol-1-yl)-phenylsul...)
Affinity DataIC50:  830nMAssay Description:Inhibition of 5-lipoxygenase mediated LTB4 synthesis in A-23187 simulated human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50166594((1S,3S)-3-{3-[4-(2-Methyl-imidazol-1-yl)-phenylsul...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of 5-lipoxygenase mediated LTB4 synthesis in A-23187 simulated human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50166589(4-{3-[4-(3,5-Dimethyl-pyrazol-1-yl)-phenylsulfanyl...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of 5-lipoxygenase mediated LTB4 synthesis in A-23187 simulated human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50166591(4-[3-(4-[1,2,4]Triazol-4-yl-phenylsulfanyl)-phenyl...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of 5-lipoxygenase mediated LTB4 synthesis in A-23187 simulated human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50166597(4-{3-[4-(2-Methyl-imidazol-1-yl)-phenylsulfanyl]-p...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of 5-lipoxygenase mediated LTB4 synthesis in A-23187 simulated human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed