Compile Data Set for Download or QSAR
maximum 50k data
Found 38 Enz. Inhib. hit(s) with all data for entry = 50016421
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168766(3-(1-(4-chlorobenzyl)-5-(2-fluoro-2'-methylbipheny...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168776(3-(5-(2'-chloro-2-fluorobiphenyl-4-yl)-1-(4-chloro...)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168760(3-(1-(4-chlorobenzyl)-5-(2-fluoro-2'-methoxybiphen...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168785(3-(5-(2'-acetyl-2-fluorobiphenyl-4-yl)-1-(4-chloro...)
Affinity DataIC50:  6nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168761(3-(1-(4-chlorobenzyl)-5-(2-fluorobiphenyl-4-yl)-3-...)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168770(3-(1-(4-chlorobenzyl)-5-(2,2'-difluorobiphenyl-4-y...)
Affinity DataIC50:  8nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168782(3-(1-(4-chlorobenzyl)-5-(3-fluoro-4-(pyridin-3-yl)...)
Affinity DataIC50:  12nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168768(3-(5-(biphenyl-4-yl)-1-(4-chlorobenzyl)-3-methyl-1...)
Affinity DataIC50:  16nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168787(3-(1-(4-chlorobenzyl)-5-(2-chlorobiphenyl-4-yl)-3-...)
Affinity DataIC50:  22nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168788(3-(1-(4-chlorobenzyl)-5-(2-fluoro-4'-methylbipheny...)
Affinity DataIC50:  31nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168777(3-[1-(4-Chloro-benzyl)-5-(3-fluoro-4-pyrazin-2-yl-...)
Affinity DataIC50:  32nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168763(3-(1-(4-chlorobenzyl)-5-(2-fluoro-3'-methylbipheny...)
Affinity DataIC50:  33nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168762(3-[5-Biphenyl-3-yl-1-(4-chloro-benzyl)-3-methyl-1H...)
Affinity DataIC50:  160nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168771(3-[1-(4-Chloro-benzyl)-3-(3,3-dimethyl-butyryl)-5-...)
Affinity DataIC50:  250nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168774(3-[3-(2-tert-Butylsulfanyl-acetyl)-1-(4-chloro-ben...)
Affinity DataIC50:  260nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168765(3-[3-(4-tert-Butyl-benzyl)-1-(4-chloro-benzyl)-5-i...)
Affinity DataIC50:  290nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168779(3-[5-tert-Butyl-1-(4-chloro-benzyl)-3-methyl-1H-in...)
Affinity DataIC50:  330nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168790(3-[1-(4-Chloro-benzyl)-3-methyl-5-phenyl-1H-indol-...)
Affinity DataIC50:  600nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168769(3-[1-(4-Chloro-benzyl)-5-isopropyl-3-phenoxy-1H-in...)
Affinity DataIC50:  650nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168781(3-[1-(4-Chloro-benzyl)-5-isopropyl-3-(2-methyl-ben...)
Affinity DataIC50:  900nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168766(3-(1-(4-chlorobenzyl)-5-(2-fluoro-2'-methylbipheny...)
Affinity DataIC50:  950nMAssay Description:In vitro inhibition against human Thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168761(3-(1-(4-chlorobenzyl)-5-(2-fluorobiphenyl-4-yl)-3-...)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro binding affinity against FLAP (5-Lipoxygenase activation protein)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168761(3-(1-(4-chlorobenzyl)-5-(2-fluorobiphenyl-4-yl)-3-...)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro inhibition against recombinant human mPGES-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168766(3-(1-(4-chlorobenzyl)-5-(2-fluoro-2'-methylbipheny...)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro inhibition against recombinant human mPGES-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168766(3-(1-(4-chlorobenzyl)-5-(2-fluoro-2'-methylbipheny...)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro binding affinity against FLAP (5-Lipoxygenase activation protein)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168784(3-[1-(4-Chloro-benzyl)-5-isopropyl-3-methyl-1H-ind...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168761(3-(1-(4-chlorobenzyl)-5-(2-fluorobiphenyl-4-yl)-3-...)
Affinity DataIC50:  1.40E+3nMAssay Description:In vitro inhibition against human Thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50006805(3-(1-(4-chlorobenzyl)-3-(tert-butylthio)-5-isoprop...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168772(3-[1-(4-Chloro-benzyl)-5-fluoro-3-methyl-1H-indol-...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168789(3-[1-(4-Chloro-benzyl)-3-methyl-1H-indol-2-yl]-2,2...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168764(3-[3-tert-Butylsulfanyl-5-isopropyl-1-(3-phenyl-pr...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168786(3-[1-(4-Chloro-benzyl)-7-isopropyl-3-methyl-1H-ind...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168775(3-[1-(4-Chloro-benzyl)-5-isopropyl-3-phenyl-1H-ind...)
Affinity DataIC50:  6.40E+3nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168778(3-(1-Allyl-3-tert-butylsulfanyl-5-isopropyl-1H-ind...)
Affinity DataIC50:  6.70E+3nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168783(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-isop...)
Affinity DataIC50:  7.20E+3nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168767(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-isop...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168780(3-(3-tert-Butylsulfanyl-5-isopropyl-1-methyl-1H-in...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168773(3-(3-tert-Butylsulfanyl-5-isopropyl-1H-indol-2-yl)...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed