Compile Data Set for Download or QSAR
maximum 50k data
Found 46 Enz. Inhib. hit(s) with all data for entry = 50016471
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169445((1S,4R,6S)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-c...)
Affinity DataIC50:  6nMAssay Description:Inhibition concentration (binding affinity) against human melanocortin receptor 4 by displacement of [125I]-NDP-alpha-MSH from the human receptors ex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169442((1R,4S,6R)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-c...)
Affinity DataIC50:  8nMAssay Description:Inhibition concentration (binding affinity) against human melanocortin receptor 4 by displacement of [125I]-NDP-alpha-MSH from the human receptors ex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169444((1S,4S,6S)-2-Aza-bicyclo[2.2.2]octane-6-carboxylic...)
Affinity DataIC50:  14nMAssay Description:Inhibition concentration (binding affinity) against human melanocortin receptor 4 by displacement of [125I]-NDP-alpha-MSH from the human receptors ex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50024351(CHEMBL2113031)
Affinity DataIC50:  16nMAssay Description:Inhibition concentration (binding affinity) against human melanocortin receptor 4 by displacement of [125I]-NDP-alpha-MSH from the human receptors ex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029747((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S...)
Affinity DataIC50:  19nMAssay Description:Inhibition concentration (binding affinity) against human melanocortin receptor 4 by displacement of [125I]-NDP-alpha-MSH from the human receptors ex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029747((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S...)
Affinity DataIC50:  19nMAssay Description:Inhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169443((1R,4S,6S)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-c...)
Affinity DataIC50:  28nMAssay Description:Inhibition concentration (binding affinity) against human melanocortin receptor 4 by displacement of [125I]-NDP-alpha-MSH from the human receptors ex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169440((1S,4R,6S)-2-Aza-bicyclo[2.2.2]octane-6-carboxylic...)
Affinity DataIC50:  41nMAssay Description:Inhibition concentration (binding affinity) against human melanocortin receptor 4 by displacement of [125I]-NDP-alpha-MSH from the human receptors ex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029747((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S...)
Affinity DataIC50:  118nMAssay Description:Effective concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]NDP-a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169445((1S,4R,6S)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-c...)
Affinity DataIC50:  410nMAssay Description:Inhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50024351(CHEMBL2113031)
Affinity DataIC50:  620nMAssay Description:Inhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169444((1S,4S,6S)-2-Aza-bicyclo[2.2.2]octane-6-carboxylic...)
Affinity DataIC50:  620nMAssay Description:Inhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50024351(CHEMBL2113031)
Affinity DataIC50:  940nMAssay Description:Inhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169444((1S,4S,6S)-2-Aza-bicyclo[2.2.2]octane-6-carboxylic...)
Affinity DataIC50:  1.02E+3nMAssay Description:Effective concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]NDP-a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169445((1S,4R,6S)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-c...)
Affinity DataIC50:  1.08E+3nMAssay Description:Effective concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]NDP-a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169443((1R,4S,6S)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-c...)
Affinity DataIC50:  1.35E+3nMAssay Description:Inhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169440((1S,4R,6S)-2-Aza-bicyclo[2.2.2]octane-6-carboxylic...)
Affinity DataIC50:  2.06E+3nMAssay Description:Inhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169442((1R,4S,6R)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-c...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition concentration (binding affinity) against mouse melanocortin receptor 4 by displacement of [125I]-NDP-alpha-MSH from the human receptors ex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169442((1R,4S,6R)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-c...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition concentration (binding affinity) against rat melanocortin receptor 4 by displacement of [125I]-NDP-alpha-MSH from the human receptors expr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169443((1R,4S,6S)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-c...)
Affinity DataIC50:  6.46E+3nMAssay Description:Inhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169442((1R,4S,6R)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-c...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition concentration (binding affinity) against dog melanocortin receptor 4 by displacement of [125I]-NDP-alpha-MSH from the human receptors expr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169440((1S,4R,6S)-2-Aza-bicyclo[2.2.2]octane-6-carboxylic...)
Affinity DataIC50:  9.87E+3nMAssay Description:Effective concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]NDP-a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdrenocorticotropic hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169442((1R,4S,6R)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-c...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition concentration (binding affinity) against human melanocortin receptor 2 by displacement of [125I]NDP-alpha-MSH from the human receptors exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169442((1R,4S,6R)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-c...)
Affinity DataIC50:  7.50E+5nMAssay Description:Inhibition concentration (binding affinity) against human melanocortin receptor 1 by displacement of [125I]NDP-alpha-MSH from the human receptors exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169442((1R,4S,6R)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-c...)
Affinity DataIC50:  9.42E+5nMAssay Description:Inhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169442((1R,4S,6R)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-c...)
Affinity DataIC50:  9.45E+5nMAssay Description:Inhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169443((1R,4S,6S)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-c...)
Affinity DataEC50:  850nMAssay Description:Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]-NDP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169443((1R,4S,6S)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-c...)
Affinity DataEC50:  165nMAssay Description:Effective concentration (binding affinity) exhibited against human melanocortin receptor 4 by radio labeled ligand assay (Displacement of [125I]-NDP-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169442((1R,4S,6R)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-c...)
Affinity DataEC50:  8.50E+5nMAssay Description:Effective concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]-NDP-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029747((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S...)
Affinity DataEC50:  17nMAssay Description:Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]-NDP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50024351(CHEMBL2113031)
Affinity DataEC50:  20nMAssay Description:Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 4 by radio labeled ligand assay (Displacement of [125I]-NDP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029747((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S...)
Affinity DataEC50:  1.10nMAssay Description:Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 3 by radio labeled ligand assay (Displacement of [125I]-NDP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169442((1R,4S,6R)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-c...)
Affinity DataEC50:  8.50E+5nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation in human melanocortin receptor (hMC5R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169442((1R,4S,6R)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-c...)
Affinity DataEC50:  1.10E+4nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation in human melanocortin receptor (hMC4R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169442((1R,4S,6R)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-c...)
Affinity DataEC50:  1.10E+4nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation in dog melanocortin receptor (dMC4R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169442((1R,4S,6R)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-c...)
Affinity DataEC50:  5.00E+3nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation in rat melanocortin receptor (rMC4R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169444((1S,4S,6S)-2-Aza-bicyclo[2.2.2]octane-6-carboxylic...)
Affinity DataEC50:  52nMAssay Description:Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 4 by radio labeled ligand assay (Displacement of [125I]-NDP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169445((1S,4R,6S)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-c...)
Affinity DataEC50:  34nMAssay Description:Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 4 by radio labeled ligand assay (Displacement of [125I]-NDP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169440((1S,4R,6S)-2-Aza-bicyclo[2.2.2]octane-6-carboxylic...)
Affinity DataEC50:  1.98E+3nMAssay Description:Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]-NDP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169442((1R,4S,6R)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-c...)
Affinity DataEC50:  1.60E+5nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation in human melanocortin receptor (hMC1R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169440((1S,4R,6S)-2-Aza-bicyclo[2.2.2]octane-6-carboxylic...)
Affinity DataEC50:  238nMAssay Description:Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 4 by radio labeled ligand assay (Displacement of [125I]-NDP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169442((1R,4S,6R)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-c...)
Affinity DataEC50:  8.50E+5nMAssay Description:Effective concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]-NDP-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029747((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S...)
Affinity DataEC50:  1.90nMAssay Description:Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 4 by radio labeled ligand assay (Displacement of [125I]-NDP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169442((1R,4S,6R)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-c...)
Affinity DataEC50:  1.10E+4nMAssay Description:Effective concentration (binding affinity) exhibited against human melanocortin receptor 4 by radio labeled ligand assay (Displacement of [125I]-NDP-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169442((1R,4S,6R)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-c...)
Affinity DataEC50:  6.00E+3nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation in mouse melanocortin receptor (mMC4R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169442((1R,4S,6R)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-c...)
Affinity DataEC50:  1.60E+5nMAssay Description:Effective concentration (binding affinity) exhibited against human melanocortin receptor 1 by radio labeled ligand assay (Displacement of [125I]-NDP-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed