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Found 18 Enz. Inhib. hit(s) with all data for entry = 50016606
TargetCaspase-1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50171145((S)-2-(2-Chloro-phenyl)-8-oxo-5,6,7,8-tetrahydro-1...)
Affinity DataIC50:  14nMAssay Description:Inhibitory activity towards CASP1 using fluorogenic substrates following an incubation for over 30 min at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50171144((S)-2-(3-Chloro-phenyl)-8-oxo-5,6,7,8-tetrahydro-1...)
Affinity DataIC50:  55nMAssay Description:Inhibitory activity towards CASP1 using fluorogenic substrates following an incubation for over 30 min at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50171146((S)-2-(4-Chloro-phenyl)-8-oxo-5,6,7,8-tetrahydro-1...)
Affinity DataIC50:  97nMAssay Description:Inhibitory activity towards CASP1 using fluorogenic substrates following an incubation for over 30 min at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50171147((S)-8-Oxo-2-phenyl-5,6,7,8-tetrahydro-1H-1,4,7a-tr...)
Affinity DataIC50:  264nMAssay Description:Inhibitory activity towards CASP1 using fluorogenic substrates following an incubation for over 30 min at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50171145((S)-2-(2-Chloro-phenyl)-8-oxo-5,6,7,8-tetrahydro-1...)
Affinity DataIC50:  336nMAssay Description:Inhibitory activity towards CASP8 using fluorogenic substrates following an incubation for over 30 min at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50171149((S)-2-tert-Butyl-8-oxo-5,6,7,8-tetrahydro-1H-1,4,7...)
Affinity DataIC50:  421nMAssay Description:Inhibitory activity towards CASP1 using fluorogenic substrates following an incubation for over 30 min at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50171144((S)-2-(3-Chloro-phenyl)-8-oxo-5,6,7,8-tetrahydro-1...)
Affinity DataIC50:  1.82E+3nMAssay Description:Inhibitory activity towards CASP8 using fluorogenic substrates following an incubation for over 30 min at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50171145((S)-2-(2-Chloro-phenyl)-8-oxo-5,6,7,8-tetrahydro-1...)
Affinity DataIC50:  1.84E+3nMAssay Description:Inhibitory activity towards CASP3 using fluorogenic substrates following an incubation for over 30 min at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50171149((S)-2-tert-Butyl-8-oxo-5,6,7,8-tetrahydro-1H-1,4,7...)
Affinity DataIC50:  2.29E+3nMAssay Description:Inhibitory activity towards CASP3 using fluorogenic substrates following an incubation for over 30 min at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50171147((S)-8-Oxo-2-phenyl-5,6,7,8-tetrahydro-1H-1,4,7a-tr...)
Affinity DataIC50:  3.05E+3nMAssay Description:Inhibitory activity towards CASP8 using fluorogenic substrates following an incubation for over 30 min at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50171144((S)-2-(3-Chloro-phenyl)-8-oxo-5,6,7,8-tetrahydro-1...)
Affinity DataIC50:  4.39E+3nMAssay Description:Inhibitory activity towards CASP3 using fluorogenic substrates following an incubation for over 30 min at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50171148((S)-9-Oxo-1,2,3,9-tetrahydro-pyrrolo[2,1-b]quinazo...)
Affinity DataIC50:  4.58E+3nMAssay Description:Inhibitory activity towards CASP1 using fluorogenic substrates following an incubation for over 30 min at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50171146((S)-2-(4-Chloro-phenyl)-8-oxo-5,6,7,8-tetrahydro-1...)
Affinity DataIC50:  4.81E+3nMAssay Description:Inhibitory activity towards CASP8 using fluorogenic substrates following an incubation for over 30 min at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50171149((S)-2-tert-Butyl-8-oxo-5,6,7,8-tetrahydro-1H-1,4,7...)
Affinity DataIC50:  7.54E+3nMAssay Description:Inhibitory activity towards CASP8 using fluorogenic substrates following an incubation for over 30 min at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50171147((S)-8-Oxo-2-phenyl-5,6,7,8-tetrahydro-1H-1,4,7a-tr...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibitory activity towards CASP3 using fluorogenic substrates following an incubation for over 30 min at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50171146((S)-2-(4-Chloro-phenyl)-8-oxo-5,6,7,8-tetrahydro-1...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibitory activity towards CASP3 using fluorogenic substrates following an incubation for over 30 min at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50171148((S)-9-Oxo-1,2,3,9-tetrahydro-pyrrolo[2,1-b]quinazo...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibitory activity towards CASP8 using fluorogenic substrates following an incubation for over 30 min at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50171148((S)-9-Oxo-1,2,3,9-tetrahydro-pyrrolo[2,1-b]quinazo...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibitory activity towards CASP3 using fluorogenic substrates following an incubation for over 30 min at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed