Compile Data Set for Download or QSAR
maximum 50k data
Found 37 Enz. Inhib. hit(s) with all data for entry = 50016771
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50240981(4'-piperazin-1-yl-biphenyl-4-carboxylic acid [1-(c...)
Affinity DataIC50:  0.400nMAssay Description:Inhibitory activity against cathepsin K using humanized rabbit enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19854(CHEMBL426819 | CRA-013783/L-006235 | N-{1-[(cyanom...)
Affinity DataIC50:  0.600nMAssay Description:Inhibitory activity against cathepsin K using humanized rabbit enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173405((S)-2-[1-(4-Bromo-phenyl)-2,2,2-trifluoro-ethylami...)
Affinity DataIC50:  0.900nMAssay Description:Inhibitory activity against cathepsin K from humanized rabbit enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150528((S)-4-Methyl-2-[4-(4-piperazin-1-yl-phenyl)-thioph...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against cathepsin K using humanized rabbit enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173405((S)-2-[1-(4-Bromo-phenyl)-2,2,2-trifluoro-ethylami...)
Affinity DataIC50:  1.30nMAssay Description:Inhibitory activity against cathepsin K using humanized rabbit enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173404((S)-2-[1-(4-Bromo-phenyl)-2,2,3,3,3-pentafluoro-pr...)
Affinity DataIC50:  2.40nMAssay Description:Inhibitory activity against cathepsin K using humanized rabbit enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173400((S)-2-{[(4-Bromo-phenyl)-(4-methanesulfonyl-phenyl...)
Affinity DataIC50:  2.5nMAssay Description:Inhibitory activity against cathepsin K using humanized rabbit enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173403(4-Methyl-2-[2,2,2-trifluoro-1-(4'-piperazin-1-yl-b...)
Affinity DataIC50:  4.60nMAssay Description:Inhibitory activity against cathepsin K using humanized rabbit enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173401(1-[2,2,2-Trifluoro-1-(4'-piperazin-1-yl-biphenyl-4...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against cathepsin K using humanized rabbit enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19856((2R)-N-(cyanomethyl)-4-methyl-2-{3-[4-(piperazin-1...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity against cathepsin K using humanized rabbit enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173408((S)-2-{[(4-Bromo-phenyl)-cyano-methyl]-amino}-4-me...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity against cathepsin K using humanized rabbit enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173405((S)-2-[1-(4-Bromo-phenyl)-2,2,2-trifluoro-ethylami...)
Affinity DataIC50:  34nMAssay Description:Inhibitory activity against cathepsin L from humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19518((2S)-N-(cyanomethyl)-4-methyl-2-{[(1S)-2,2,2-trifl...)
Affinity DataIC50:  47nMAssay Description:Inhibitory activity against cathepsin L from humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173403(4-Methyl-2-[2,2,2-trifluoro-1-(4'-piperazin-1-yl-b...)
Affinity DataIC50:  68nMAssay Description:Inhibitory activity against cathepsin L from humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150528((S)-4-Methyl-2-[4-(4-piperazin-1-yl-phenyl)-thioph...)
Affinity DataIC50:  102nMAssay Description:Inhibitory activity against cathepsin S from humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173405((S)-2-[1-(4-Bromo-phenyl)-2,2,2-trifluoro-ethylami...)
Affinity DataIC50:  121nMAssay Description:Inhibitory activity against cathepsin S from humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150528((S)-4-Methyl-2-[4-(4-piperazin-1-yl-phenyl)-thioph...)
Affinity DataIC50:  123nMAssay Description:Inhibitory activity against cathepsin B from humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150528((S)-4-Methyl-2-[4-(4-piperazin-1-yl-phenyl)-thioph...)
Affinity DataIC50:  352nMAssay Description:Inhibitory activity against cathepsin L from humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19518((2S)-N-(cyanomethyl)-4-methyl-2-{[(1S)-2,2,2-trifl...)
Affinity DataIC50:  451nMAssay Description:Inhibitory activity against cathepsin S from humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50240981(4'-piperazin-1-yl-biphenyl-4-carboxylic acid [1-(c...)
Affinity DataIC50:  614nMAssay Description:Inhibitory activity against cathepsin B from humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173402((S)-2-(4-Bromo-benzylamino)-4-methyl-pentanoic aci...)
Affinity DataIC50:  802nMAssay Description:Inhibitory activity against cathepsin K using humanized rabbit enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173403(4-Methyl-2-[2,2,2-trifluoro-1-(4'-piperazin-1-yl-b...)
Affinity DataIC50:  902nMAssay Description:Inhibitory activity against cathepsin S from humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173406((S)-2-[1-(4-Bromo-phenyl)-ethylamino]-4-methyl-pen...)
Affinity DataIC50:  988nMAssay Description:Inhibitory activity against cathepsin K using humanized rabbit enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19854(CHEMBL426819 | CRA-013783/L-006235 | N-{1-[(cyanom...)
Affinity DataIC50:  1.05E+3nMAssay Description:Inhibitory activity against cathepsin B from humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19518((2S)-N-(cyanomethyl)-4-methyl-2-{[(1S)-2,2,2-trifl...)
Affinity DataIC50:  1.11E+3nMAssay Description:Inhibitory activity against cathepsin B from humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19856((2R)-N-(cyanomethyl)-4-methyl-2-{3-[4-(piperazin-1...)
Affinity DataIC50:  2.01E+3nMAssay Description:Inhibitory activity against cathepsin S from humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50240981(4'-piperazin-1-yl-biphenyl-4-carboxylic acid [1-(c...)
Affinity DataIC50:  2.27E+3nMAssay Description:Inhibitory activity against cathepsin L from humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173405((S)-2-[1-(4-Bromo-phenyl)-2,2,2-trifluoro-ethylami...)
Affinity DataIC50:  3.35E+3nMAssay Description:Inhibitory activity against cathepsin B from humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19856((2R)-N-(cyanomethyl)-4-methyl-2-{3-[4-(piperazin-1...)
Affinity DataIC50:  3.73E+3nMAssay Description:Inhibitory activity against cathepsin L from humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19854(CHEMBL426819 | CRA-013783/L-006235 | N-{1-[(cyanom...)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibitory activity against cathepsin L from humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19856((2R)-N-(cyanomethyl)-4-methyl-2-{3-[4-(piperazin-1...)
Affinity DataIC50:  3.95E+3nMAssay Description:Inhibitory activity against cathepsin B from humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50240981(4'-piperazin-1-yl-biphenyl-4-carboxylic acid [1-(c...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against cathepsin S from humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173401(1-[2,2,2-Trifluoro-1-(4'-piperazin-1-yl-biphenyl-4...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against cathepsin L from humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173401(1-[2,2,2-Trifluoro-1-(4'-piperazin-1-yl-biphenyl-4...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against cathepsin B from humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19854(CHEMBL426819 | CRA-013783/L-006235 | N-{1-[(cyanom...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against cathepsin S from humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173403(4-Methyl-2-[2,2,2-trifluoro-1-(4'-piperazin-1-yl-b...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against cathepsin B from humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173401(1-[2,2,2-Trifluoro-1-(4'-piperazin-1-yl-biphenyl-4...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against cathepsin S from humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed