BindingDB PrimarySearch

Found 26 Enz. Inhib. hit(s) with all data for entry = 50017027

cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)

IC50: 40nMAssay Description:Inhibitory activity against PDE2 by scintillation proximity assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM28393((+)-EHNA | (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...)

IC50: 635nMAssay Description:Inhibitory activity against PDE2 by scintillation proximity assayMore data for this Ligand-Target Pair

PDB Reactome pathway
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3D Structure (crystal)

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)

IC50: 1.16E+4nMAssay Description:Inhibitory activity against PDE11 by scintillation proximity assayMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
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cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)

IC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE3 by scintillation proximity assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)

IC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE5 by scintillation proximity assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM28393((+)-EHNA | (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...)

IC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE11 by scintillation proximity assayMore data for this Ligand-Target Pair

Reactome pathway KEGG
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cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM28393((+)-EHNA | (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...)

IC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE3 by scintillation proximity assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM28393((+)-EHNA | (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...)

IC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE4D by scintillation proximity assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)

IC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE10 by scintillation proximity assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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cAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM28393((+)-EHNA | (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...)

IC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE4C by scintillation proximity assayMore data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)

IC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE4C by scintillation proximity assayMore data for this Ligand-Target Pair

PDB Reactome pathway
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antibodypedia GoogleScholar

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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)

IC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE4D by scintillation proximity assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)

IC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE8A by scintillation proximity assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)

IC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)

IC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE4A by scintillation proximity assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)

IC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE9 by scintillation proximity assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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cAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM28393((+)-EHNA | (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...)

IC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE4A by scintillation proximity assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM28393((+)-EHNA | (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...)

IC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE8B by scintillation proximity assayMore data for this Ligand-Target Pair

Reactome pathway KEGG
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM28393((+)-EHNA | (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...)

IC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM28393((+)-EHNA | (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...)

IC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE10 by scintillation proximity assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM28393((+)-EHNA | (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...)

IC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE9 by scintillation proximity assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)

IC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE8B by scintillation proximity assayMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)

IC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE1 by scintillation proximity assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM28393((+)-EHNA | (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...)

IC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE8A by scintillation proximity assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM28393((+)-EHNA | (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...)

IC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE1 by scintillation proximity assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM28393((+)-EHNA | (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...)

IC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE5 by scintillation proximity assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Filter my 26 hits

Targets 13▿
- Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A 2
- cGMP-specific 3',5'-cyclic phosphodiesterase 2
- High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A 2
- High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B 2
- cAMP-specific 3',5'-cyclic phosphodiesterase 4B 2
- cGMP-dependent 3',5'-cyclic phosphodiesterase 2
- cAMP-specific 3',5'-cyclic phosphodiesterase 4C 2
- cAMP-specific 3',5'-cyclic phosphodiesterase 4D 2
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C 2
- High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A 2
- cAMP-specific 3',5'-cyclic phosphodiesterase 4A 2
- cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B 2
- cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 2
Publications 1▿
- Bioorg Med Chem Lett 16: 307-10 (2005) 26
Institutions 1▿
- Pfizer 26
Affinity: 40 to 1.6E+4 nM▿
- IC50 26
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 2