Compile Data Set for Download or QSAR
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Found 68 Enz. Inhib. hit(s) with all data for entry = 50017304
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180334(2-(3,4-Methylenedioxyphenylamino)-6-(3-acetamidoph...)
Affinity DataIC50:  32nMAssay Description:Growth inhibition in human melanoma cells WM266.4 expressing mutant B-RAF with SRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  46nMAssay Description:Inhibitory activity against human B-RAFMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180359(2-(3-Oxo-1,3-dihydroisobenzofuran-5-ylamino)-6-(3-...)
Affinity DataIC50:  490nMAssay Description:Growth inhibition in human melanoma cells WM266.4 expressing mutant B-RAF with SRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180359(2-(3-Oxo-1,3-dihydroisobenzofuran-5-ylamino)-6-(3-...)
Affinity DataIC50:  740nMAssay Description:Inhibitory activity against human B-RAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180350(2-[3-(Oxazol-5-yl)phenylamino]-6-(3-acetamidopheny...)
Affinity DataIC50:  790nMAssay Description:Inhibitory activity against human B-RAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180353(2-(2,6-Dichloropyridin-4-ylamino)-6-(3-acetamidoph...)
Affinity DataIC50:  950nMAssay Description:Inhibitory activity against human B-RAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180339(2-(3,4-Dimethoxyphenylamino)-6-(3-acetamidophenyl)...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibitory activity against human B-RAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180330(2-(3-Chlorophenylamino)-6-(3-acetamidophenyl)pyraz...)
Affinity DataIC50:  1.40E+3nMAssay Description:Growth inhibition in human melanoma cells WM266.4 expressing mutant B-RAF with SRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180354(2-(4-Morpholinophenylamino)-6-(3-acetamidophenyl)p...)
Affinity DataIC50:  2.30E+3nMAssay Description:Growth inhibition in human melanoma cells WM266.4 expressing mutant B-RAF with SRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180331(2-(3,5-Dimethoxyphenylamino)-6-(3-acetamidophenyl)...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibitory activity against human B-RAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180337(2-(2,3-Dihydrobenzo[b][1,4]dioxin-6-ylamino)-6-(3-...)
Affinity DataIC50:  3.00E+3nMAssay Description:Growth inhibition in human melanoma cells WM266.4 expressing mutant B-RAF with SRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180331(2-(3,5-Dimethoxyphenylamino)-6-(3-acetamidophenyl)...)
Affinity DataIC50:  3.00E+3nMAssay Description:Growth inhibition in human melanoma cells WM266.4 expressing mutant B-RAF with SRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180356(2-(3,4-Dihydro-2H-benzo[b][1,4]dioxepin-7-ylamino)...)
Affinity DataIC50:  3.30E+3nMAssay Description:Growth inhibition in human melanoma cells WM266.4 expressing mutant B-RAF with SRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM25561(2,6-Disubstituted Pyrazine, 1 | CHEMBL200114 | N-(...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibitory activity against human B-RAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM25561(2,6-Disubstituted Pyrazine, 1 | CHEMBL200114 | N-(...)
Affinity DataIC50:  3.60E+3nMAssay Description:Growth inhibition in human melanoma cells WM266.4 expressing mutant B-RAF with SRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180332(2-(3,4-Methylenedioxyphenylaminomethyl)-6-(3-aceta...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibitory activity against human B-RAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180358(2-[3-(2-Aminoethoxy)phenylamino]-6-(3-acetamidophe...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibitory activity against human B-RAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180341(2-(3-Methoxyphenylamino)-6-(3-acetamidophenyl)pyra...)
Affinity DataIC50:  4.00E+3nMAssay Description:Growth inhibition in human melanoma cells WM266.4 expressing mutant B-RAF with SRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180333(2-[(5-Methyl-3-isoxazolyl)methylamino]-6-(3-acetam...)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibitory activity against human B-RAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180356(2-(3,4-Dihydro-2H-benzo[b][1,4]dioxepin-7-ylamino)...)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibitory activity against human B-RAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180341(2-(3-Methoxyphenylamino)-6-(3-acetamidophenyl)pyra...)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibitory activity against human B-RAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180355(2-[4-(Trifluoromethoxy)phenylamino]-6-(3-acetamido...)
Affinity DataIC50:  5.20E+3nMAssay Description:Growth inhibition in human melanoma cells WM266.4 expressing mutant B-RAF with SRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180358(2-[3-(2-Aminoethoxy)phenylamino]-6-(3-acetamidophe...)
Affinity DataIC50:  5.20E+3nMAssay Description:Growth inhibition in human melanoma cells WM266.4 expressing mutant B-RAF with SRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180337(2-(2,3-Dihydrobenzo[b][1,4]dioxin-6-ylamino)-6-(3-...)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibitory activity against human B-RAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  6.10E+3nMAssay Description:Growth inhibition in human melanoma cells WM266.4 expressing mutant B-RAF with SRBMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180339(2-(3,4-Dimethoxyphenylamino)-6-(3-acetamidophenyl)...)
Affinity DataIC50:  6.40E+3nMAssay Description:Growth inhibition in human melanoma cells WM266.4 expressing mutant B-RAF with SRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180352(2-(Phenylamino)-6-(3-acetamidophenyl)pyrazine | CH...)
Affinity DataIC50:  7.90E+3nMAssay Description:Inhibitory activity against human B-RAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180344(2-(3-Fluorophenylmethylamino)-6-(3'-acetamidopheny...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibitory activity against human B-RAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180357(2-[4-(Morpholinosulfonyl)phenylamino]-6-(3-acetami...)
Affinity DataIC50:  8.30E+3nMAssay Description:Growth inhibition in human melanoma cells WM266.4 expressing mutant B-RAF with SRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180330(2-(3-Chlorophenylamino)-6-(3-acetamidophenyl)pyraz...)
Affinity DataIC50:  8.80E+3nMAssay Description:Inhibitory activity against human B-RAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180357(2-[4-(Morpholinosulfonyl)phenylamino]-6-(3-acetami...)
Affinity DataIC50:  8.80E+3nMAssay Description:Inhibitory activity against human B-RAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180351(2-(2,4-Dimethoxyphenylamino)-6-(3-acetamidophenyl)...)
Affinity DataIC50:  8.80E+3nMAssay Description:Growth inhibition in human melanoma cells WM266.4 expressing mutant B-RAF with SRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180354(2-(4-Morpholinophenylamino)-6-(3-acetamidophenyl)p...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibitory activity against human B-RAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180334(2-(3,4-Methylenedioxyphenylamino)-6-(3-acetamidoph...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibitory activity against human B-RAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180352(2-(Phenylamino)-6-(3-acetamidophenyl)pyrazine | CH...)
Affinity DataIC50:  1.20E+4nMAssay Description:Growth inhibition in human melanoma cells WM266.4 expressing mutant B-RAF with SRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180327(2-[(1,5-Dimethyl-1H-pyrazol-3-yl)methylamino]-6-(3...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibitory activity against human B-RAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180360(2-(3-Hydroxyphenylamino)-6-(3-acetamidophenyl)pyra...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibitory activity against human B-RAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180363(2-(Benzylamino)-6-(3-acetamidophenyl)pyrazine | CH...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibitory activity against human B-RAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180327(2-[(1,5-Dimethyl-1H-pyrazol-3-yl)methylamino]-6-(3...)
Affinity DataIC50:  1.80E+4nMAssay Description:Growth inhibition in human melanoma cells WM266.4 expressing mutant B-RAF with SRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180329(2-(4-tert-Butylthiazol-2-ylamino)-6-(3-acetamidoph...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibitory activity against human B-RAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180351(2-(2,4-Dimethoxyphenylamino)-6-(3-acetamidophenyl)...)
Affinity DataIC50:  2.10E+4nMAssay Description:Inhibitory activity against human B-RAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180362(CHEMBL199798 | N-(3-(6-(4-methoxyphenylamino)pyraz...)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibitory activity against human B-RAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180347(2-(3-Chloro-4-fluorobenzylamino)-6-(3-acetamidophe...)
Affinity DataIC50:  2.70E+4nMAssay Description:Growth inhibition in human melanoma cells WM266.4 expressing mutant B-RAF with SRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180338(2-(3-Phenylpropylamino)-6-(3-acetamidophenyl)pyraz...)
Affinity DataIC50:  3.30E+4nMAssay Description:Growth inhibition in human melanoma cells WM266.4 expressing mutant B-RAF with SRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180342(2-(3-Furylmethylamino)-6-(3-acetamidophenyl)pyrazi...)
Affinity DataIC50:  3.30E+4nMAssay Description:Inhibitory activity against human B-RAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180340(2-Phenoxyethylamino-6-(3-acetamidophenyl)pyrazine ...)
Affinity DataIC50:  3.30E+4nMAssay Description:Growth inhibition in human melanoma cells WM266.4 expressing mutant B-RAF with SRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180365(2-(2,3-Dehydro-1,4-benzodioxin-6-methylamino)-6-(3...)
Affinity DataIC50:  3.40E+4nMAssay Description:Inhibitory activity against human B-RAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180336(2-(3,4,5-Trimethoxybenzylamino)-6-(3-acetamidophen...)
Affinity DataIC50:  3.70E+4nMAssay Description:Growth inhibition in human melanoma cells WM266.4 expressing mutant B-RAF with SRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180345(2-(2,2-Difluorobenzo[d][1,3]dioxol-5-ylamino)-6-(3...)
Affinity DataIC50:  3.70E+4nMAssay Description:Inhibitory activity against human B-RAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50180349(2-(4-Methoxyphenyloxyethylamino)-6-(3-acetamidophe...)
Affinity DataIC50:  3.80E+4nMAssay Description:Growth inhibition in human melanoma cells WM266.4 expressing mutant B-RAF with SRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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