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PubMed code 16403626

Compile data set for download or QSAR
Found 55 hits of Enzyme Inhibition Constant Data   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15097
PNG
(N-[(2S)-2-amino-3-(1H-indol-3-yl)propyl]-5-[(E)-2-...)
Show SMILES N[C@H](CNc1cncc(\C=C\c2ccncc2)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H23N5/c24-20(12-19-14-28-23-4-2-1-3-22(19)23)15-27-21-11-18(13-26-16-21)6-5-17-7-9-25-10-8-17/h1-11,13-14,16,20,27-28H,12,15,24H2/b6-5+/t20-/m0/s1
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n/an/a 9.70n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15022
PNG
(3-[(2S)-2-amino-3-({5-[(E)-2-(pyridin-4-yl)ethenyl...)
Show SMILES N[C@H](COc1cncc(\C=C\c2ccncc2)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H22N4O/c24-20(12-19-14-27-23-4-2-1-3-22(19)23)16-28-21-11-18(13-26-15-21)6-5-17-7-9-25-10-8-17/h1-11,13-15,20,27H,12,16,24H2/b6-5+/t20-/m0/s1
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n/an/a 14n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15095
PNG
(N-[(2S)-2-amino-3-(1H-indol-3-yl)propyl]-6-chloro-...)
Show SMILES N[C@H](CNc1cnc(Cl)c(\C=C\c2ccncc2)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H22ClN5/c24-23-17(6-5-16-7-9-26-10-8-16)12-20(15-29-23)27-14-19(25)11-18-13-28-22-4-2-1-3-21(18)22/h1-10,12-13,15,19,27-28H,11,14,25H2/b6-5+/t19-/m0/s1
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n/an/a 19n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15088
PNG
(3-[(2S)-2-amino-3-({6-chloro-5-[(E)-2-(pyridin-4-y...)
Show SMILES N[C@H](COc1cnc(Cl)c(\C=C\c2ccncc2)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H21ClN4O/c24-23-17(6-5-16-7-9-26-10-8-16)12-20(14-28-23)29-15-19(25)11-18-13-27-22-4-2-1-3-21(18)22/h1-10,12-14,19,27H,11,15,25H2/b6-5+/t19-/m0/s1
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n/an/a 23n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM15022
PNG
(3-[(2S)-2-amino-3-({5-[(E)-2-(pyridin-4-yl)ethenyl...)
Show SMILES N[C@H](COc1cncc(\C=C\c2ccncc2)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H22N4O/c24-20(12-19-14-27-23-4-2-1-3-22(19)23)16-28-21-11-18(13-26-15-21)6-5-17-7-9-25-10-8-17/h1-11,13-15,20,27H,12,16,24H2/b6-5+/t20-/m0/s1
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n/an/a 38n/an/an/an/a7.422



Abbott Laboratories



Assay Description
The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15118
PNG
(4-[(E)-2-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy...)
Show SMILES N[C@H](COc1cncc(\C=C\c2ccnc(NC3CC3)c2)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C26H27N5O/c27-21(13-20-15-30-25-4-2-1-3-24(20)25)17-32-23-11-19(14-28-16-23)6-5-18-9-10-29-26(12-18)31-22-7-8-22/h1-6,9-12,14-16,21-22,30H,7-8,13,17,27H2,(H,29,31)/b6-5+/t21-/m0/s1
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n/an/a 69n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15096
PNG
(N-[(2S)-2-amino-3-(2,3-dihydro-1H-indol-3-yl)propy...)
Show SMILES N[C@H](CNc1cnc(Cl)c(\C=C\c2ccncc2)c1)CC1CNc2ccccc12
Show InChI InChI=1S/C23H24ClN5/c24-23-17(6-5-16-7-9-26-10-8-16)12-20(15-29-23)27-14-19(25)11-18-13-28-22-4-2-1-3-21(18)22/h1-10,12,15,18-19,27-28H,11,13-14,25H2/b6-5+/t18?,19-/m0/s1
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n/an/a 79n/an/an/an/a7.522



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15115
PNG
(4-[(E)-2-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy...)
Show SMILES N[C@H](COc1cncc(\C=C\c2ccnc(N)c2)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H23N5O/c24-19(11-18-13-28-22-4-2-1-3-21(18)22)15-29-20-9-17(12-26-14-20)6-5-16-7-8-27-23(25)10-16/h1-10,12-14,19,28H,11,15,24H2,(H2,25,27)/b6-5+/t19-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15085
PNG
(3-[(2S)-2-amino-3-(1-benzothiophen-3-yl)propoxy]-5...)
Show SMILES N[C@H](COc1cncc(\C=C\c2ccncc2)c1)Cc1csc2ccccc12
Show InChI InChI=1S/C23H21N3OS/c24-20(12-19-16-28-23-4-2-1-3-22(19)23)15-27-21-11-18(13-26-14-21)6-5-17-7-9-25-10-8-17/h1-11,13-14,16,20H,12,15,24H2/b6-5+/t20-/m0/s1
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n/an/a 142n/an/an/an/a7.522



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15084
PNG
(3-[(2S)-2-amino-3-(naphthalen-2-yl)propoxy]-5-[(E)...)
Show SMILES N[C@H](COc1cncc(\C=C\c2ccncc2)c1)Cc1ccc2ccccc2c1
Show InChI InChI=1S/C25H23N3O/c26-24(14-20-7-8-22-3-1-2-4-23(22)13-20)18-29-25-15-21(16-28-17-25)6-5-19-9-11-27-12-10-19/h1-13,15-17,24H,14,18,26H2/b6-5+/t24-/m0/s1
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n/an/a 146n/an/an/an/a7.522



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15119
PNG
(4-[(E)-2-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy...)
Show SMILES N[C@H](COc1cncc(\C=C\c2ccnc(NCc3ccccc3)c2)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C30H29N5O/c31-26(16-25-19-34-29-9-5-4-8-28(25)29)21-36-27-14-24(17-32-20-27)11-10-22-12-13-33-30(15-22)35-18-23-6-2-1-3-7-23/h1-15,17,19-20,26,34H,16,18,21,31H2,(H,33,35)/b11-10+/t26-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15117
PNG
(4-[(E)-2-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy...)
Show SMILES CCNc1cc(\C=C\c2cncc(OC[C@@H](N)Cc3c[nH]c4ccccc34)c2)ccn1
Show InChI InChI=1S/C25H27N5O/c1-2-28-25-12-18(9-10-29-25)7-8-19-11-22(16-27-14-19)31-17-21(26)13-20-15-30-24-6-4-3-5-23(20)24/h3-12,14-16,21,30H,2,13,17,26H2,1H3,(H,28,29)/b8-7+/t21-/m0/s1
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n/an/a 163n/an/an/an/a7.522



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15116
PNG
(4-[(E)-2-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy...)
Show SMILES CNc1cc(\C=C\c2cncc(OC[C@@H](N)Cc3c[nH]c4ccccc34)c2)ccn1
Show InChI InChI=1S/C24H25N5O/c1-26-24-11-17(8-9-28-24)6-7-18-10-21(15-27-13-18)30-16-20(25)12-19-14-29-23-5-3-2-4-22(19)23/h2-11,13-15,20,29H,12,16,25H2,1H3,(H,26,28)/b7-6+/t20-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15094
PNG
((2R)-4-{6-chloro-5-[(E)-2-(pyridin-4-yl)ethenyl]py...)
Show SMILES N[C@H](CCc1cnc(Cl)c(\C=C\c2ccncc2)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C24H23ClN4/c25-24-19(7-5-17-9-11-27-12-10-17)13-18(15-29-24)6-8-21(26)14-20-16-28-23-4-2-1-3-22(20)23/h1-5,7,9-13,15-16,21,28H,6,8,14,26H2/b7-5+/t21-/m1/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM15022
PNG
(3-[(2S)-2-amino-3-({5-[(E)-2-(pyridin-4-yl)ethenyl...)
Show SMILES N[C@H](COc1cncc(\C=C\c2ccncc2)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H22N4O/c24-20(12-19-14-27-23-4-2-1-3-22(19)23)16-28-21-11-18(13-26-15-21)6-5-17-7-9-25-10-8-17/h1-11,13-15,20,27H,12,16,24H2/b6-5+/t20-/m0/s1
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n/an/a 257n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15089
PNG
(3-[(2S)-2-amino-3-({2-chloro-5-[(E)-2-(pyridin-4-y...)
Show SMILES N[C@H](COc1cc(\C=C\c2ccncc2)cnc1Cl)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H21ClN4O/c24-23-22(11-17(13-28-23)6-5-16-7-9-26-10-8-16)29-15-19(25)12-18-14-27-21-4-2-1-3-20(18)21/h1-11,13-14,19,27H,12,15,25H2/b6-5+/t19-/m0/s1
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Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15098
PNG
((2S)-2-amino-3-(1H-indol-3-yl)-N-{5-[(E)-2-(pyridi...)
Show SMILES N[C@@H](Cc1c[nH]c2ccccc12)C(=O)Nc1cncc(\C=C\c2ccncc2)c1
Show InChI InChI=1S/C23H21N5O/c24-21(12-18-14-27-22-4-2-1-3-20(18)22)23(29)28-19-11-17(13-26-15-19)6-5-16-7-9-25-10-8-16/h1-11,13-15,21,27H,12,24H2,(H,28,29)/b6-5+/t21-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15103
PNG
(2-phenyl-2-{5-[(E)-2-(pyridin-4-yl)ethenyl]pyridin...)
Show SMILES NCC(c1ccccc1)c1cncc(\C=C\c2ccncc2)c1
Show InChI InChI=1S/C20H19N3/c21-13-20(18-4-2-1-3-5-18)19-12-17(14-23-15-19)7-6-16-8-10-22-11-9-16/h1-12,14-15,20H,13,21H2/b7-6+
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15082
PNG
(3-[(2S)-2-amino-3-({5-[(E)-2-(pyridin-4-yl)ethenyl...)
Show SMILES N[C@H](COc1cncc(\C=C\c2ccncc2)c1)Cc1cccc(c1)C#N
Show InChI InChI=1S/C22H20N4O/c23-13-19-3-1-2-18(10-19)11-21(24)16-27-22-12-20(14-26-15-22)5-4-17-6-8-25-9-7-17/h1-10,12,14-15,21H,11,16,24H2/b5-4+/t21-/m0/s1
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Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15083
PNG
(3-[(2S)-2-amino-3-(naphthalen-1-yl)propoxy]-5-[(E)...)
Show SMILES N[C@H](COc1cncc(\C=C\c2ccncc2)c1)Cc1cccc2ccccc12
Show InChI InChI=1S/C25H23N3O/c26-23(15-22-6-3-5-21-4-1-2-7-25(21)22)18-29-24-14-20(16-28-17-24)9-8-19-10-12-27-13-11-19/h1-14,16-17,23H,15,18,26H2/b9-8+/t23-/m0/s1
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Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM15022
PNG
(3-[(2S)-2-amino-3-({5-[(E)-2-(pyridin-4-yl)ethenyl...)
Show SMILES N[C@H](COc1cncc(\C=C\c2ccncc2)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H22N4O/c24-20(12-19-14-27-23-4-2-1-3-22(19)23)16-28-21-11-18(13-26-15-21)6-5-17-7-9-25-10-8-17/h1-11,13-15,20,27H,12,16,24H2/b6-5+/t20-/m0/s1
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n/an/a 354n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15087
PNG
(3-[(2R)-2-amino-3-({5-[(E)-2-(pyridin-4-yl)ethenyl...)
Show SMILES N[C@@H](COc1cncc(\C=C\c2ccncc2)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H22N4O/c24-20(12-19-14-27-23-4-2-1-3-22(19)23)16-28-21-11-18(13-26-15-21)6-5-17-7-9-25-10-8-17/h1-11,13-15,20,27H,12,16,24H2/b6-5+/t20-/m1/s1
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n/an/a 360n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15090
PNG
(3-[(2S)-2-amino-3-({5-[(E)-2-(pyridin-4-yl)ethenyl...)
Show SMILES Cn1cc(C[C@H](N)COc2cncc(\C=C\c3ccncc3)c2)c2ccccc12
Show InChI InChI=1S/C24H24N4O/c1-28-16-20(23-4-2-3-5-24(23)28)13-21(25)17-29-22-12-19(14-27-15-22)7-6-18-8-10-26-11-9-18/h2-12,14-16,21H,13,17,25H2,1H3/b7-6+/t21-/m0/s1
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n/an/a 500n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15101
PNG
((2S)-2-amino-3-(naphthalen-1-yl)-N-{5-[(E)-2-(pyri...)
Show SMILES N[C@@H](Cc1cccc2ccccc12)C(=O)Nc1cncc(\C=C\c2ccncc2)c1
Show InChI InChI=1S/C25H22N4O/c26-24(15-21-6-3-5-20-4-1-2-7-23(20)21)25(30)29-22-14-19(16-28-17-22)9-8-18-10-12-27-13-11-18/h1-14,16-17,24H,15,26H2,(H,29,30)/b9-8+/t24-/m0/s1
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n/an/a 668n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15021
PNG
(3-[(2S)-2-amino-3-phenylpropoxy]-5-[(E)-2-(pyridin...)
Show SMILES N[C@H](COc1cncc(\C=C\c2ccncc2)c1)Cc1ccccc1
Show InChI InChI=1S/C21H21N3O/c22-20(12-18-4-2-1-3-5-18)16-25-21-13-19(14-24-15-21)7-6-17-8-10-23-11-9-17/h1-11,13-15,20H,12,16,22H2/b7-6+/t20-/m0/s1
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n/an/a 690n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15104
PNG
(2-(1-methyl-1H-indol-3-yl)-2-{5-[(E)-2-(pyridin-4-...)
Show SMILES Cn1cc(C(CN)c2cncc(\C=C\c3ccncc3)c2)c2ccccc12
Show InChI InChI=1S/C23H22N4/c1-27-16-22(20-4-2-3-5-23(20)27)21(13-24)19-12-18(14-26-15-19)7-6-17-8-10-25-11-9-17/h2-12,14-16,21H,13,24H2,1H3/b7-6+
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n/an/a 760n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15081
PNG
(3-[(2S)-2-amino-3-({5-[(E)-2-(pyridin-4-yl)ethenyl...)
Show SMILES N[C@H](COc1cncc(\C=C\c2ccncc2)c1)Cc1cccc(O)c1
Show InChI InChI=1S/C21H21N3O2/c22-19(10-17-2-1-3-20(25)11-17)15-26-21-12-18(13-24-14-21)5-4-16-6-8-23-9-7-16/h1-9,11-14,19,25H,10,15,22H2/b5-4+/t19-/m0/s1
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n/an/a 875n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15091
PNG
([(2S)-1-(1H-indol-3-yl)-3-({5-[(E)-2-(pyridin-4-yl...)
Show SMILES CN(C)[C@H](COc1cncc(\C=C\c2ccncc2)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C25H26N4O/c1-29(2)22(14-21-16-28-25-6-4-3-5-24(21)25)18-30-23-13-20(15-27-17-23)8-7-19-9-11-26-12-10-19/h3-13,15-17,22,28H,14,18H2,1-2H3/b8-7+/t22-/m0/s1
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n/an/a 1.10E+3n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15111
PNG
(3-[(2S)-2-amino-3-({5-[(E)-2-(2-methoxypyridin-4-y...)
Show SMILES COc1cc(\C=C\c2cncc(OC[C@@H](N)Cc3c[nH]c4ccccc34)c2)ccn1
Show InChI InChI=1S/C24H24N4O2/c1-29-24-11-17(8-9-27-24)6-7-18-10-21(15-26-13-18)30-16-20(25)12-19-14-28-23-5-3-2-4-22(19)23/h2-11,13-15,20,28H,12,16,25H2,1H3/b7-6+/t20-/m0/s1
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n/an/a 2.67E+3n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15114
PNG
(3-[(2S)-2-amino-3-({5-[(E)-2-[2-(benzylsulfanyl)py...)
Show SMILES N[C@H](COc1cncc(\C=C\c2ccnc(SCc3ccccc3)c2)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C30H28N4OS/c31-26(16-25-18-34-29-9-5-4-8-28(25)29)20-35-27-14-24(17-32-19-27)11-10-22-12-13-33-30(15-22)36-21-23-6-2-1-3-7-23/h1-15,17-19,26,34H,16,20-21,31H2/b11-10+/t26-/m0/s1
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n/an/a 3.11E+3n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15100
PNG
((2S)-2-amino-3-phenyl-N-{5-[(E)-2-(pyridin-4-yl)et...)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)Nc1cncc(\C=C\c2ccncc2)c1
Show InChI InChI=1S/C21H20N4O/c22-20(13-17-4-2-1-3-5-17)21(26)25-19-12-18(14-24-15-19)7-6-16-8-10-23-11-9-16/h1-12,14-15,20H,13,22H2,(H,25,26)/b7-6+/t20-/m0/s1
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n/an/a 3.20E+3n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15120
PNG
(1-{4-[(E)-2-{5-[(2S)-2-amino-3-(1H-indol-3-yl)prop...)
Show SMILES N[C@H](COc1cncc(\C=C\c2ccnc(c2)-n2ccc3ccccc23)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C31H27N5O/c32-26(17-25-19-35-29-7-3-2-6-28(25)29)21-37-27-15-23(18-33-20-27)10-9-22-11-13-34-31(16-22)36-14-12-24-5-1-4-8-30(24)36/h1-16,18-20,26,35H,17,21,32H2/b10-9+/t26-/m0/s1
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n/an/a 3.34E+3n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15079
PNG
((2S)-1-(benzyloxy)-3-({5-[(E)-2-(pyridin-4-yl)ethe...)
Show SMILES N[C@@H](COCc1ccccc1)COc1cncc(\C=C\c2ccncc2)c1
Show InChI InChI=1S/C22H23N3O2/c23-21(16-26-15-19-4-2-1-3-5-19)17-27-22-12-20(13-25-14-22)7-6-18-8-10-24-11-9-18/h1-14,21H,15-17,23H2/b7-6+/t21-/m0/s1
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n/an/a 4.04E+3n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15070
PNG
(3-(2-aminoethoxy)-5-[(E)-2-(pyridin-4-yl)ethenyl]p...)
Show SMILES NCCOc1cncc(\C=C\c2ccncc2)c1
Show InChI InChI=1S/C14H15N3O/c15-5-8-18-14-9-13(10-17-11-14)2-1-12-3-6-16-7-4-12/h1-4,6-7,9-11H,5,8,15H2/b2-1+
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n/an/a 5.08E+3n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15069
PNG
(5-[(2S)-2-aminopropoxy]-2-chloro-3-[(E)-2-(pyridin...)
Show SMILES C[C@H](N)COc1cnc(Cl)c(\C=C\c2ccncc2)c1
Show InChI InChI=1S/C15H16ClN3O/c1-11(17)10-20-14-8-13(15(16)19-9-14)3-2-12-4-6-18-7-5-12/h2-9,11H,10,17H2,1H3/b3-2+/t11-/m0/s1
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n/an/a 5.29E+3n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15113
PNG
(3-[(2S)-2-amino-3-({5-[(E)-2-[2-(phenylsulfanyl)py...)
Show SMILES N[C@H](COc1cncc(\C=C\c2ccnc(Sc3ccccc3)c2)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C29H26N4OS/c30-24(16-23-18-33-28-9-5-4-8-27(23)28)20-34-25-14-22(17-31-19-25)11-10-21-12-13-32-29(15-21)35-26-6-2-1-3-7-26/h1-15,17-19,24,33H,16,20,30H2/b11-10+/t24-/m0/s1
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n/an/a 6.35E+3n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15112
PNG
(3-[(2S)-2-amino-3-({5-[(E)-2-(2-phenoxypyridin-4-y...)
Show SMILES N[C@H](COc1cncc(\C=C\c2ccnc(Oc3ccccc3)c2)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C29H26N4O2/c30-24(16-23-18-33-28-9-5-4-8-27(23)28)20-34-26-14-22(17-31-19-26)11-10-21-12-13-32-29(15-21)35-25-6-2-1-3-7-25/h1-15,17-19,24,33H,16,20,30H2/b11-10+/t24-/m0/s1
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n/an/a 6.45E+3n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15077
PNG
(3-[(2S)-2-amino-3,3-diphenylpropoxy]-5-[(E)-2-(pyr...)
Show SMILES N[C@H](COc1cncc(\C=C\c2ccncc2)c1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H25N3O/c28-26(27(23-7-3-1-4-8-23)24-9-5-2-6-10-24)20-31-25-17-22(18-30-19-25)12-11-21-13-15-29-16-14-21/h1-19,26-27H,20,28H2/b12-11+/t26-/m1/s1
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n/an/a 6.76E+3n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15078
PNG
(3-[(2S)-2-amino-4-phenylbutoxy]-5-[(E)-2-(pyridin-...)
Show SMILES N[C@@H](CCc1ccccc1)COc1cncc(\C=C\c2ccncc2)c1
Show InChI InChI=1S/C22H23N3O/c23-21(9-8-18-4-2-1-3-5-18)17-26-22-14-20(15-25-16-22)7-6-19-10-12-24-13-11-19/h1-7,10-16,21H,8-9,17,23H2/b7-6+/t21-/m0/s1
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n/an/a 8.02E+3n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15074
PNG
(3-[(2S)-azetidin-2-ylmethoxy]-5-[(E)-2-(pyridin-4-...)
Show SMILES C(Oc1cncc(\C=C\c2ccncc2)c1)[C@@H]1CCN1
Show InChI InChI=1S/C16H17N3O/c1(13-3-6-17-7-4-13)2-14-9-16(11-18-10-14)20-12-15-5-8-19-15/h1-4,6-7,9-11,15,19H,5,8,12H2/b2-1+/t15-/m0/s1
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n/an/a 1.09E+4n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15071
PNG
(3-(3-aminopropoxy)-5-[(E)-2-(pyridin-4-yl)ethenyl]...)
Show SMILES NCCCOc1cncc(\C=C\c2ccncc2)c1
Show InChI InChI=1S/C15H17N3O/c16-6-1-9-19-15-10-14(11-18-12-15)3-2-13-4-7-17-8-5-13/h2-5,7-8,10-12H,1,6,9,16H2/b3-2+
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n/an/a 1.47E+4n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15072
PNG
(3-[(2S)-2-amino-3-methylbutoxy]-5-[(E)-2-(pyridin-...)
Show SMILES CC(C)[C@H](N)COc1cncc(\C=C\c2ccncc2)c1
Show InChI InChI=1S/C17H21N3O/c1-13(2)17(18)12-21-16-9-15(10-20-11-16)4-3-14-5-7-19-8-6-14/h3-11,13,17H,12,18H2,1-2H3/b4-3+/t17-/m1/s1
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n/an/a 1.93E+4n/an/an/an/a7.522



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15108
PNG
(3-[(2S)-2-amino-3-({6-[(E)-2-(pyridin-4-yl)ethenyl...)
Show SMILES N[C@H](COc1cccc(\C=C\c2ccncc2)n1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H22N4O/c24-19(14-18-15-26-22-6-2-1-5-21(18)22)16-28-23-7-3-4-20(27-23)9-8-17-10-12-25-13-11-17/h1-13,15,19,26H,14,16,24H2/b9-8+/t19-/m0/s1
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n/an/a 2.33E+4n/an/an/an/a7.522



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15075
PNG
(3-[(E)-2-(pyridin-4-yl)ethenyl]-5-[(2S)-pyrrolidin...)
Show SMILES C(Oc1cncc(\C=C\c2ccncc2)c1)[C@@H]1CCCN1
Show InChI InChI=1S/C17H19N3O/c1-2-16(20-7-1)13-21-17-10-15(11-19-12-17)4-3-14-5-8-18-9-6-14/h3-6,8-12,16,20H,1-2,7,13H2/b4-3+/t16-/m0/s1
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n/an/a 2.39E+4n/an/an/an/a7.522



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15092
PNG
(1-(1H-indol-3-yl)-3-({5-[(E)-2-(pyridin-4-yl)ethen...)
Show SMILES OC(COc1cncc(\C=C\c2ccncc2)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H21N3O2/c27-20(12-19-14-26-23-4-2-1-3-22(19)23)16-28-21-11-18(13-25-15-21)6-5-17-7-9-24-10-8-17/h1-11,13-15,20,26-27H,12,16H2/b6-5+
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n/an/a 2.40E+4n/an/an/an/a7.522



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15102
PNG
([(2E)-3-(4-bromophenyl)prop-2-en-1-yl][2-({5-[(E)-...)
Show SMILES Brc1ccc(\C=C\CNCCOc2cncc(\C=C\c3ccncc3)c2)cc1
Show InChI InChI=1S/C23H22BrN3O/c24-22-7-5-19(6-8-22)2-1-11-25-14-15-28-23-16-21(17-27-18-23)4-3-20-9-12-26-13-10-20/h1-10,12-13,16-18,25H,11,14-15H2/b2-1+,4-3+
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n/an/a 3.23E+4n/an/an/an/a7.522



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15110
PNG
(2-[(2S)-2-amino-3-phenylpropoxy]-5-[(E)-2-(pyridin...)
Show SMILES N[C@H](COc1ccc(\C=C\c2ccncc2)cn1)Cc1ccccc1
Show InChI InChI=1S/C21H21N3O/c22-20(14-18-4-2-1-3-5-18)16-25-21-9-8-19(15-24-21)7-6-17-10-12-23-13-11-17/h1-13,15,20H,14,16,22H2/b7-6+/t20-/m0/s1
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n/an/a 4.30E+4n/an/an/an/a7.522



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15093
PNG
(3-[3-({5-[(E)-2-(pyridin-4-yl)ethenyl]pyridin-3-yl...)
Show SMILES C(COc1cncc(\C=C\c2ccncc2)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H21N3O/c1-2-6-23-22(5-1)20(16-26-23)4-3-13-27-21-14-19(15-25-17-21)8-7-18-9-11-24-12-10-18/h1-2,5-12,14-17,26H,3-4,13H2/b8-7+
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n/an/a>5.00E+4n/an/an/an/a7.522



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15073
PNG
((2R)-2-amino-3-({5-[(E)-2-(pyridin-4-yl)ethenyl]py...)
Show SMILES N[C@H](COc1cncc(\C=C\c2ccncc2)c1)C(O)=O
Show InChI InChI=1S/C15H15N3O3/c16-14(15(19)20)10-21-13-7-12(8-18-9-13)2-1-11-3-5-17-6-4-11/h1-9,14H,10,16H2,(H,19,20)/b2-1+/t14-/m1/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15080
PNG
((2R)-2-amino-N-(naphthalen-2-yl)-3-({5-[(E)-2-(pyr...)
Show SMILES N[C@H](COc1cncc(\C=C\c2ccncc2)c1)C(=O)Nc1ccc2ccccc2c1
Show InChI InChI=1S/C25H22N4O2/c26-24(25(30)29-22-8-7-20-3-1-2-4-21(20)14-22)17-31-23-13-19(15-28-16-23)6-5-18-9-11-27-12-10-18/h1-16,24H,17,26H2,(H,29,30)/b6-5+/t24-/m1/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15109
PNG
(3-[(2S)-2-amino-3-phenylpropoxy]-4-[(E)-2-(pyridin...)
Show SMILES N[C@H](COc1cnccc1\C=C\c1ccncc1)Cc1ccccc1
Show InChI InChI=1S/C21H21N3O/c22-20(14-18-4-2-1-3-5-18)16-25-21-15-24-13-10-19(21)7-6-17-8-11-23-12-9-17/h1-13,15,20H,14,16,22H2/b7-6+/t20-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15107
PNG
(3-[(2S)-2-amino-3-({4-[(E)-2-(pyridin-4-yl)ethenyl...)
Show SMILES N[C@H](COc1cc(\C=C\c2ccncc2)ccn1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H22N4O/c24-20(14-19-15-27-22-4-2-1-3-21(19)22)16-28-23-13-18(9-12-26-23)6-5-17-7-10-25-11-8-17/h1-13,15,20,27H,14,16,24H2/b6-5+/t20-/m0/s1
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Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15106
PNG
(3-[(2S)-2-amino-3-{3-[(E)-2-(pyridin-4-yl)ethenyl]...)
Show SMILES N[C@H](COc1cccc(\C=C\c2ccncc2)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C24H23N3O/c25-21(15-20-16-27-24-7-2-1-6-23(20)24)17-28-22-5-3-4-19(14-22)9-8-18-10-12-26-13-11-18/h1-14,16,21,27H,15,17,25H2/b9-8+/t21-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15105
PNG
(3-[(2S)-2-amino-3-({5-[(E)-2-phenylethenyl]pyridin...)
Show SMILES N[C@H](COc1cncc(\C=C\c2ccccc2)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C24H23N3O/c25-21(13-20-15-27-24-9-5-4-8-23(20)24)17-28-22-12-19(14-26-16-22)11-10-18-6-2-1-3-7-18/h1-12,14-16,21,27H,13,17,25H2/b11-10+/t21-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (human))
BDBM15099
PNG
((2S)-2-amino-3-(1H-imidazol-5-yl)-N-{5-[(E)-2-(pyr...)
Show SMILES N[C@@H](Cc1cnc[nH]1)C(=O)Nc1cncc(C=Cc2ccncc2)c1
Show InChI InChI=1S/C18H18N6O/c19-17(8-15-10-22-12-23-15)18(25)24-16-7-14(9-21-11-16)2-1-13-3-5-20-6-4-13/h1-7,9-12,17H,8,19H2,(H,22,23)(H,24,25)/t17-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 1679-85 (2006)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%