BindingDB logo
myBDB logout

PubMed code 1654430

Compile data set for download or QSAR
Found 51 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229570
PNG
(CHEMBL98208)
Show SMILES Cc1cc2[nH]c3nc(O)nc3cc2c(C)c1Br
Show InChI InChI=1S/C12H10BrN3O/c1-5-3-8-7(6(2)10(5)13)4-9-11(14-8)16-12(17)15-9/h3-4H,1-2H3,(H2,14,15,16,17)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229564
PNG
(CHEMBL98269)
Show SMILES COc1cc2cc3[nH]c(O)nc3nc2cc1OC
Show InChI InChI=1S/C12H11N3O3/c1-17-9-4-6-3-8-11(15-12(16)14-8)13-7(6)5-10(9)18-2/h3-5H,1-2H3,(H2,13,14,15,16)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229568
PNG
(CHEMBL100676)
Show SMILES CC(C)Oc1ccc2[nH]c3nc(O)nc3cc2c1
Show InChI InChI=1S/C13H13N3O2/c1-7(2)18-9-3-4-10-8(5-9)6-11-12(14-10)16-13(17)15-11/h3-7H,1-2H3,(H2,14,15,16,17)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50000925
PNG
(7,8-Dimethyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-...)
Show SMILES Cc1ccc2nc3[nH]c(=O)[nH]c3cc2c1C
Show InChI InChI=1S/C12H11N3O/c1-6-3-4-9-8(7(6)2)5-10-11(13-9)15-12(16)14-10/h3-5H,1-2H3,(H2,13,14,15,16)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229569
PNG
(CHEMBL97922)
Show SMILES Cc1cccc2[nH]c3nc(O)nc3cc12
Show InChI InChI=1S/C11H9N3O/c1-6-3-2-4-8-7(6)5-9-10(12-8)14-11(15)13-9/h2-5H,1H3,(H2,12,13,14,15)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229566
PNG
(CHEMBL98268)
Show SMILES Cc1cc2[nH]c3nc(O)nc3cc2c(C)c1Cl
Show InChI InChI=1S/C12H10ClN3O/c1-5-3-8-7(6(2)10(5)13)4-9-11(14-8)16-12(17)15-9/h3-4H,1-2H3,(H2,14,15,16,17)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 20n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229572
PNG
(CHEMBL98812)
Show SMILES CCOc1ccc2[nH]c3nc(O)nc3cc2c1
Show InChI InChI=1S/C12H11N3O2/c1-2-17-8-3-4-9-7(5-8)6-10-11(13-9)15-12(16)14-10/h3-6H,2H2,1H3,(H2,13,14,15,16)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 20n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50007229
PNG
(7-Fluoro-1,3,9,9a-tetrahydro-imidazo[4,5-b]quinoli...)
Show SMILES Fc1ccc2Nc3[nH]c(=O)[nH]c3Cc2c1
Show InChI InChI=1S/C10H8FN3O/c11-6-1-2-7-5(3-6)4-8-9(12-7)14-10(15)13-8/h1-3,12H,4H2,(H2,13,14,15)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 30n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229557
PNG
(CHEMBL100784)
Show SMILES COc1ccc2[nH]c3nc(O)nc3cc2c1
Show InChI InChI=1S/C11H9N3O2/c1-16-7-2-3-8-6(4-7)5-9-10(12-8)14-11(15)13-9/h2-5H,1H3,(H2,12,13,14,15)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 35n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229558
PNG
(CHEMBL319947)
Show SMILES Cc1ccc2[nH]c3nc(O)nc3cc2c1Cl
Show InChI InChI=1S/C11H8ClN3O/c1-5-2-3-7-6(9(5)12)4-8-10(13-7)15-11(16)14-8/h2-4H,1H3,(H2,13,14,15,16)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 40n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229563
PNG
(CHEMBL99760)
Show SMILES Cc1cc2[nH]c3nc(O)nc3cc2cc1Cl
Show InChI InChI=1S/C11H8ClN3O/c1-5-2-8-6(3-7(5)12)4-9-10(13-8)15-11(16)14-9/h2-4H,1H3,(H2,13,14,15,16)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 50n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50000334
PNG
(6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...)
Show SMILES Clc1ccc2N=C3NC(=O)CN3Cc2c1Cl
Show InChI InChI=1S/C10H7Cl2N3O/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7/h1-2H,3-4H2,(H,13,14,16)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 50n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50007221
PNG
(7-Chloro-1,3-dihydro-imidazo[4,5-b]quinolin-2-one ...)
Show SMILES Clc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C10H6ClN3O/c11-6-1-2-7-5(3-6)4-8-9(12-7)14-10(15)13-8/h1-4H,(H2,12,13,14,15)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 50n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50007216
PNG
(7-Methyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-one ...)
Show SMILES Cc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C11H9N3O/c1-6-2-3-8-7(4-6)5-9-10(12-8)14-11(15)13-9/h2-5H,1H3,(H2,12,13,14,15)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 50n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229561
PNG
(CHEMBL317399)
Show SMILES Cc1cc2cc3[nH]c(O)nc3nc2cc1C
Show InChI InChI=1S/C12H11N3O/c1-6-3-8-5-10-11(15-12(16)14-10)13-9(8)4-7(6)2/h3-5H,1-2H3,(H2,13,14,15,16)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 80n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229556
PNG
(CHEMBL319551)
Show SMILES Cc1cccc2cc3[nH]c(O)nc3nc12
Show InChI InChI=1S/C11H9N3O/c1-6-3-2-4-7-5-8-10(13-9(6)7)14-11(15)12-8/h2-5H,1H3,(H2,12,13,14,15)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 90n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50007222
PNG
(1,3,9,9a-Tetrahydro-imidazo[4,5-b]quinolin-2-one |...)
Show SMILES O=c1[nH]c2Cc3ccccc3Nc2[nH]1
Show InChI InChI=1S/C10H9N3O/c14-10-12-8-5-6-3-1-2-4-7(6)11-9(8)13-10/h1-4,11H,5H2,(H2,12,13,14)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 100n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229562
PNG
(CHEMBL98164)
Show SMILES COc1cccc2[nH]c3nc(O)nc3cc12
Show InChI InChI=1S/C11H9N3O2/c1-16-9-4-2-3-7-6(9)5-8-10(12-7)14-11(15)13-8/h2-5H,1H3,(H2,12,13,14,15)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 150n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229567
PNG
(CHEMBL98687)
Show SMILES CC(=O)Oc1ccc2[nH]c3nc(O)nc3cc2c1
Show InChI InChI=1S/C12H9N3O3/c1-6(16)18-8-2-3-9-7(4-8)5-10-11(13-9)15-12(17)14-10/h2-5H,1H3,(H2,13,14,15,17)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 200n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229565
PNG
(CHEMBL99996)
Show SMILES Cc1ccc2N=C3NC(=O)NC3Cc2c1
Show InChI InChI=1S/C11H11N3O/c1-6-2-3-8-7(4-6)5-9-10(12-8)14-11(15)13-9/h2-4,9H,5H2,1H3,(H2,12,13,14,15)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 300n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50007234
PNG
(7-Fluoro-1,3-dihydro-imidazo[4,5-b]quinolin-2-one ...)
Show SMILES Fc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C10H6FN3O/c11-6-1-2-7-5(3-6)4-8-9(12-7)14-10(15)13-8/h1-4H,(H2,12,13,14,15)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 300n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229559
PNG
(CHEMBL98373)
Show SMILES Oc1nc2cc3c(Cl)cccc3[nH]c2n1
Show InChI InChI=1S/C10H6ClN3O/c11-6-2-1-3-7-5(6)4-8-9(12-7)14-10(15)13-8/h1-4H,(H2,12,13,14,15)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 300n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229560
PNG
(CHEMBL98024)
Show SMILES Oc1nc2cc3cc(O)ccc3[nH]c2n1
Show InChI InChI=1S/C10H7N3O2/c14-6-1-2-7-5(3-6)4-8-9(11-7)13-10(15)12-8/h1-4,14H,(H2,11,12,13,15)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 300n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50007220
PNG
(1,3-Dihydro-imidazo[4,5-b]quinolin-2-one | CHEMBL9...)
Show SMILES O=c1[nH]c2cc3ccccc3nc2[nH]1
Show InChI InChI=1S/C10H7N3O/c14-10-12-8-5-6-3-1-2-4-7(6)11-9(8)13-10/h1-5H,(H2,11,12,13,14)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 500n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50007247
PNG
(1,7,8-Trimethyl-1,3-dihydro-imidazo[4,5-b]quinolin...)
Show SMILES Cc1ccc2nc3[nH]c(=O)n(C)c3cc2c1C
Show InChI InChI=1S/C13H13N3O/c1-7-4-5-10-9(8(7)2)6-11-12(14-10)15-13(17)16(11)3/h4-6H,1-3H3,(H,14,15,17)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.50E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229550
PNG
(CHEMBL98340)
Show SMILES COc1cc2[nH]c3nc(O)nc3cc2c(OC)c1OC
Show InChI InChI=1S/C13H13N3O4/c1-18-9-5-7-6(10(19-2)11(9)20-3)4-8-12(14-7)16-13(17)15-8/h4-5H,1-3H3,(H2,14,15,16,17)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229555
PNG
(CHEMBL99507)
Show SMILES COc1cccc2cc3[nH]c(O)nc3nc12
Show InChI InChI=1S/C11H9N3O2/c1-16-8-4-2-3-6-5-7-10(13-9(6)8)14-11(15)12-7/h2-5H,1H3,(H2,12,13,14,15)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50007235
PNG
(1,7-Dimethyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-...)
Show SMILES Cc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C12H11N3O/c1-7-3-4-9-8(5-7)6-10-11(13-9)14-12(16)15(10)2/h3-6H,1-2H3,(H,13,14,16)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229551
PNG
(CHEMBL100365)
Show SMILES Cc1ccc2nc3n(C)c(O)nc3cc2c1C
Show InChI InChI=1S/C13H13N3O/c1-7-4-5-10-9(8(7)2)6-11-12(14-10)16(3)13(17)15-11/h4-6H,1-3H3,(H,15,17)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50007250
PNG
(7-Methoxy-1-methyl-1,3-dihydro-imidazo[4,5-b]quino...)
Show SMILES COc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C12H11N3O2/c1-15-10-6-7-5-8(17-2)3-4-9(7)13-11(10)14-12(15)16/h3-6H,1-2H3,(H,13,14,16)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229553
PNG
(CHEMBL100030)
Show SMILES COc1ccc2nc3n(C)c(O)nc3cc2c1
Show InChI InChI=1S/C12H11N3O2/c1-15-11-10(14-12(15)16)6-7-5-8(17-2)3-4-9(7)13-11/h3-6H,1-2H3,(H,14,16)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50007248
PNG
(1,8-Dimethyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-...)
Show SMILES Cc1cccc2nc3[nH]c(=O)n(C)c3cc12
Show InChI InChI=1S/C12H11N3O/c1-7-4-3-5-9-8(7)6-10-11(13-9)14-12(16)15(10)2/h3-6H,1-2H3,(H,13,14,16)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 7.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50007236
PNG
(1,3-Dihydro-naphtho[2,3-d]imidazol-2-one | CHEMBL3...)
Show SMILES O=c1[nH]c2cc3ccccc3cc2[nH]1
Show InChI InChI=1S/C11H8N2O/c14-11-12-9-5-7-3-1-2-4-8(7)6-10(9)13-11/h1-6H,(H2,12,13,14)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 7.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50007217
PNG
(7-Chloro-1,3,9,9a-tetrahydro-imidazo[4,5-b]quinoli...)
Show SMILES Clc1ccc2Nc3[nH]c(=O)[nH]c3Cc2c1
Show InChI InChI=1S/C10H8ClN3O/c11-6-1-2-7-5(3-6)4-8-9(12-7)14-10(15)13-8/h1-3,12H,4H2,(H2,13,14,15)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 9.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000925
PNG
(7,8-Dimethyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-...)
Show SMILES Cc1ccc2nc3[nH]c(=O)[nH]c3cc2c1C
Show InChI InChI=1S/C12H11N3O/c1-6-3-4-9-8(7(6)2)5-10-11(13-9)15-12(16)14-10/h3-5H,1-2H3,(H2,13,14,15,16)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50007227
PNG
(1-Methyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-one ...)
Show SMILES Cn1c2cc3ccccc3nc2[nH]c1=O
Show InChI InChI=1S/C11H9N3O/c1-14-9-6-7-4-2-3-5-8(7)12-10(9)13-11(14)15/h2-6H,1H3,(H,12,13,15)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50007250
PNG
(7-Methoxy-1-methyl-1,3-dihydro-imidazo[4,5-b]quino...)
Show SMILES COc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C12H11N3O2/c1-15-10-6-7-5-8(17-2)3-4-9(7)13-11(10)14-12(15)16/h3-6H,1-2H3,(H,13,14,16)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 3.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000334
PNG
(6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...)
Show SMILES Clc1ccc2N=C3NC(=O)CN3Cc2c1Cl
Show InChI InChI=1S/C10H7Cl2N3O/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7/h1-2H,3-4H2,(H,13,14,16)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 3.40E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50007229
PNG
(7-Fluoro-1,3,9,9a-tetrahydro-imidazo[4,5-b]quinoli...)
Show SMILES Fc1ccc2Nc3[nH]c(=O)[nH]c3Cc2c1
Show InChI InChI=1S/C10H8FN3O/c11-6-1-2-7-5(3-6)4-8-9(12-7)14-10(15)13-8/h1-3,12H,4H2,(H2,13,14,15)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50007248
PNG
(1,8-Dimethyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-...)
Show SMILES Cc1cccc2nc3[nH]c(=O)n(C)c3cc12
Show InChI InChI=1S/C12H11N3O/c1-7-4-3-5-9-8(7)6-10-11(13-9)14-12(16)15(10)2/h3-6H,1-2H3,(H,13,14,16)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 6.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50007227
PNG
(1-Methyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-one ...)
Show SMILES Cn1c2cc3ccccc3nc2[nH]c1=O
Show InChI InChI=1S/C11H9N3O/c1-14-9-6-7-4-2-3-5-8(7)12-10(9)13-11(14)15/h2-6H,1H3,(H,12,13,15)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229554
PNG
(CHEMBL99441)
Show SMILES Cc1ccc2nc3n(C)c(=O)n(C)c3cc2c1C
Show InChI InChI=1S/C14H15N3O/c1-8-5-6-11-10(9(8)2)7-12-13(15-11)17(4)14(18)16(12)3/h5-7H,1-4H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50007235
PNG
(1,7-Dimethyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-...)
Show SMILES Cc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C12H11N3O/c1-7-3-4-9-8(5-7)6-10-11(13-9)14-12(16)15(10)2/h3-6H,1-2H3,(H,13,14,16)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 7.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50007220
PNG
(1,3-Dihydro-imidazo[4,5-b]quinolin-2-one | CHEMBL9...)
Show SMILES O=c1[nH]c2cc3ccccc3nc2[nH]1
Show InChI InChI=1S/C10H7N3O/c14-10-12-8-5-6-3-1-2-4-7(6)11-9(8)13-10/h1-5H,(H2,11,12,13,14)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 8.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50007217
PNG
(7-Chloro-1,3,9,9a-tetrahydro-imidazo[4,5-b]quinoli...)
Show SMILES Clc1ccc2Nc3[nH]c(=O)[nH]c3Cc2c1
Show InChI InChI=1S/C10H8ClN3O/c11-6-1-2-7-5(3-6)4-8-9(12-7)14-10(15)13-8/h1-3,12H,4H2,(H2,13,14,15)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50007234
PNG
(7-Fluoro-1,3-dihydro-imidazo[4,5-b]quinolin-2-one ...)
Show SMILES Fc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C10H6FN3O/c11-6-1-2-7-5(3-6)4-8-9(12-7)14-10(15)13-8/h1-4H,(H2,12,13,14,15)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50007216
PNG
(7-Methyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-one ...)
Show SMILES Cc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C11H9N3O/c1-6-2-3-8-7(4-6)5-9-10(12-8)14-11(15)13-9/h2-5H,1H3,(H2,12,13,14,15)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50007222
PNG
(1,3,9,9a-Tetrahydro-imidazo[4,5-b]quinolin-2-one |...)
Show SMILES O=c1[nH]c2Cc3ccccc3Nc2[nH]1
Show InChI InChI=1S/C10H9N3O/c14-10-12-8-5-6-3-1-2-4-7(6)11-9(8)13-10/h1-4,11H,5H2,(H2,12,13,14)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50007236
PNG
(1,3-Dihydro-naphtho[2,3-d]imidazol-2-one | CHEMBL3...)
Show SMILES O=c1[nH]c2cc3ccccc3cc2[nH]1
Show InChI InChI=1S/C11H8N2O/c14-11-12-9-5-7-3-1-2-4-8(7)6-10(9)13-11/h1-6H,(H2,12,13,14)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50007247
PNG
(1,7,8-Trimethyl-1,3-dihydro-imidazo[4,5-b]quinolin...)
Show SMILES Cc1ccc2nc3[nH]c(=O)n(C)c3cc2c1C
Show InChI InChI=1S/C13H13N3O/c1-7-4-5-10-9(8(7)2)6-11-12(14-10)15-13(17)16(11)3/h4-6H,1-3H3,(H,14,15,17)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50007221
PNG
(7-Chloro-1,3-dihydro-imidazo[4,5-b]quinolin-2-one ...)
Show SMILES Clc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C10H6ClN3O/c11-6-1-2-7-5(3-6)4-8-9(12-7)14-10(15)13-8/h1-4H,(H2,12,13,14,15)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase


J Med Chem 34: 2906-16 (1991)


Article DOI: 10.1021/jm00113a033
BindingDB Entry DOI: 10.7270/Q20P0Z03
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%