Compile Data Set for Download or QSAR
maximum 50k data
Found 18 Enz. Inhib. hit(s) with all data for entry = 50000564
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50007314(CHEMBL104834 | [2-(3,4-Dichloro-phenyl)-ethyl]-(2-...)
Affinity DataKi:  0.490nMAssay Description:Inhibiton of [3H]-(+)-3-PPP binding to sigma of guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50007316((3,4-Dichloro-benzyl)-methyl-(2-pyrrolidin-1-yl-cy...)
Affinity DataKi:  1.20nMAssay Description:Compound was tested for the inhibitory activity against Sigma opioid receptor by using [3H]-(+)-3-PPP as radioligand in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50003743((-)-[2-(3,4-Dichloro-phenyl)-ethyl]-methyl-(2-pyrr...)
Affinity DataKi:  1.30nMAssay Description:Inhibiton of [3H]-(+)-3-PPP binding to sigma of guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50003743((-)-[2-(3,4-Dichloro-phenyl)-ethyl]-methyl-(2-pyrr...)
Affinity DataKi:  2nMAssay Description:Inhibiton of [3H]-(+)-3-PPP binding to sigma of guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50007312(CHEMBL320828 | [2-(3,4-Dichloro-phenyl)-ethyl]-(2-...)
Affinity DataKi:  2.40nMAssay Description:Inhibiton of [3H]-(+)-3-PPP binding to sigma of guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50007315(CHEMBL103065 | [2-(3,4-Dichloro-phenyl)-ethyl]-eth...)
Affinity DataKi:  3.10nMAssay Description:Inhibiton of [3H]-(+)-3-PPP binding to sigma of guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50007313(CHEMBL102695 | [2-(3,4-Dichloro-phenyl)-ethyl]-eth...)
Affinity DataKi:  3.5nMAssay Description:Compound was tested for the inhibitory activity against Sigma opioid receptor by using [3H]-(+)-3-PPP as radioligand in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50003747((+)-[2-(3,4-Dichloro-phenyl)-ethyl]-methyl-(2-pyrr...)
Affinity DataKi:  6nMAssay Description:Inhibiton of [3H]-(+)-3-PPP binding to sigma of guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50007322(2-(3,4-Dichloro-phenyl)-N-(2-pyrrolidin-1-yl-cyclo...)
Affinity DataKi:  11nMAssay Description:Compound was tested for the inhibitory activity against Sigma opioid receptor by using [3H]-(+)-3-PPP as radioligand in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50007319(CHEMBL103849 | Cyclopropylmethyl-[2-(3,4-dichloro-...)
Affinity DataKi:  38nMAssay Description:Inhibiton of [3H]-(+)-3-PPP binding to sigma of guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50007321(CHEMBL316797 | [2-(3,4-Dichloro-phenyl)-ethyl]-pro...)
Affinity DataKi:  56nMAssay Description:Inhibiton of [3H]-(+)-3-PPP binding to sigma of guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50003749((2S)-N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(p...)
Affinity DataKi:  65nMAssay Description:Inhibiton of [3H]-(+)-3-PPP binding to sigma of guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50007317(CHEMBL104992 | [2-(3,4-Dichloro-phenyl)-ethyl]-pro...)
Affinity DataKi:  140nMAssay Description:Inhibiton of [3H]-(+)-3-PPP binding to sigma of guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50007318(2-(3,4-Dichloro-phenyl)-N-(2-pyrrolidin-1-yl-cyclo...)
Affinity DataKi:  146nMAssay Description:Inhibiton of [3H]-(+)-3-PPP binding to sigma of guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50007320(CHEMBL103519 | Cyclopropylmethyl-[2-(3,4-dichloro-...)
Affinity DataKi:  412nMAssay Description:Inhibiton of [3H]-(+)-3-PPP binding to sigma of guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50003755((2R)-N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(p...)
Affinity DataKi:  538nMAssay Description:Inhibiton of [3H]-(+)-3-PPP binding to sigma of guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50007314(CHEMBL104834 | [2-(3,4-Dichloro-phenyl)-ethyl]-(2-...)
Affinity DataKi:  6.88E+3nMAssay Description:Compound was tested for the inhibitory concentration against phencyclidine by using [3H]-TCP as radioligand at PCP receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50007314(CHEMBL104834 | [2-(3,4-Dichloro-phenyl)-ethyl]-(2-...)
Affinity DataKi:  8.51E+3nMAssay Description:Compound was tested for the inhibitory concentration against dopamine receptor D2 by using [3H]-()-sulpiride) as radioligand in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed