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PubMed code 1671416

Compile data set for download or QSAR
Found 15 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50002172
PNG
(3-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-butyl]...)
Show SMILES C(CCc1c[nH]c2ccccc12)CN1CCC(=CC1)c1ccccc1
Show InChI InChI=1S/C23H26N2/c1-2-8-19(9-3-1)20-13-16-25(17-14-20)15-7-6-10-21-18-24-23-12-5-4-11-22(21)23/h1-5,8-9,11-13,18,24H,6-7,10,14-17H2
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n/an/a 16n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory binding activity against dopamine receptor in rat striatal membranes using [3H]HAL as the radioligand.


J Med Chem 34: 248-56 (1991)


Article DOI: 10.1021/jm00105a039
BindingDB Entry DOI: 10.7270/Q20Z73WT
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM29644
PNG
((6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1ccc(O)c(O)c-31
Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1
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n/an/a 27n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory binding activity against dopamine receptor in rat striatal membranes using [3H]HAL as the radioligand.


J Med Chem 34: 248-56 (1991)


Article DOI: 10.1021/jm00105a039
BindingDB Entry DOI: 10.7270/Q20Z73WT
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50007428
PNG
(7-[3-(4-Pyridin-2-yl-piperazin-1-yl)-propoxy]-chro...)
Show SMILES O=c1ccoc2cc(OCCCN3CCN(CC3)c3ccccn3)ccc12
Show InChI InChI=1S/C21H23N3O3/c25-19-7-15-27-20-16-17(5-6-18(19)20)26-14-3-9-23-10-12-24(13-11-23)21-4-1-2-8-22-21/h1-2,4-8,15-16H,3,9-14H2
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n/an/a 59n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for its inhibitory effect on the binding profile in Dopamine receptor using [3H]N-propylnorapomorphine in rat brain.


J Med Chem 34: 248-56 (1991)


Article DOI: 10.1021/jm00105a039
BindingDB Entry DOI: 10.7270/Q20Z73WT
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50228813
PNG
(CHEMBL87419)
Show SMILES O=c1ccoc2cc(OCCCN3CCC(=CC3)c3ccccc3)ccc12
Show InChI InChI=1S/C23H23NO3/c25-22-11-16-27-23-17-20(7-8-21(22)23)26-15-4-12-24-13-9-19(10-14-24)18-5-2-1-3-6-18/h1-3,5-9,11,16-17H,4,10,12-15H2
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n/an/a 69n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory binding activity against Dopamine receptor in rat striatal membranes using [3H]HAL as the radioligand.


J Med Chem 34: 248-56 (1991)


Article DOI: 10.1021/jm00105a039
BindingDB Entry DOI: 10.7270/Q20Z73WT
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50227607
PNG
(CHEMBL44450)
Show SMILES Nc1cccc(OCCCN2CCN(CC2)c2ccccc2)c1
Show InChI InChI=1S/C19H25N3O/c20-17-6-4-9-19(16-17)23-15-5-10-21-11-13-22(14-12-21)18-7-2-1-3-8-18/h1-4,6-9,16H,5,10-15,20H2
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n/an/a 138n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory binding activity against Dopamine receptor in rat striatal membranes using [3H]HAL as the radioligand.


J Med Chem 34: 248-56 (1991)


Article DOI: 10.1021/jm00105a039
BindingDB Entry DOI: 10.7270/Q20Z73WT
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50007428
PNG
(7-[3-(4-Pyridin-2-yl-piperazin-1-yl)-propoxy]-chro...)
Show SMILES O=c1ccoc2cc(OCCCN3CCN(CC3)c3ccccn3)ccc12
Show InChI InChI=1S/C21H23N3O3/c25-19-7-15-27-20-16-17(5-6-18(19)20)26-14-3-9-23-10-12-24(13-11-23)21-4-1-2-8-22-21/h1-2,4-8,15-16H,3,9-14H2
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n/an/a 170n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for its inhibitory effect on the binding profile in Alpha-1 adrenergic receptor using [3H]prazosin in rat brain.


J Med Chem 34: 248-56 (1991)


Article DOI: 10.1021/jm00105a039
BindingDB Entry DOI: 10.7270/Q20Z73WT
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50228815
PNG
(CHEMBL85216)
Show SMILES O=c1ccoc2cc(OCCCN3CCC=C(C3)c3ccccc3)ccc12
Show InChI InChI=1S/C23H23NO3/c25-22-11-15-27-23-16-20(9-10-21(22)23)26-14-5-13-24-12-4-8-19(17-24)18-6-2-1-3-7-18/h1-3,6-11,15-16H,4-5,12-14,17H2
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n/an/a 243n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory binding activity against Dopamine receptor in rat striatal membranes using [3H]HAL as the radioligand.


J Med Chem 34: 248-56 (1991)


Article DOI: 10.1021/jm00105a039
BindingDB Entry DOI: 10.7270/Q20Z73WT
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50228814
PNG
(CHEMBL87776)
Show SMILES O=c1ccoc2ccc(OCCCCN3CCN(CC3)c3ncccn3)cc12
Show InChI InChI=1S/C21H24N4O3/c26-19-6-15-28-20-5-4-17(16-18(19)20)27-14-2-1-9-24-10-12-25(13-11-24)21-22-7-3-8-23-21/h3-8,15-16H,1-2,9-14H2
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n/an/a 349n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory binding activity against Dopamine receptor in rat striatal membranes using [3H]HAL as the radioligand.


J Med Chem 34: 248-56 (1991)


Article DOI: 10.1021/jm00105a039
BindingDB Entry DOI: 10.7270/Q20Z73WT
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50228816
PNG
(CHEMBL87750)
Show SMILES CC(CN1CCN(CC1)c1ccccn1)Cc1ccc2c(c1)occc2=O
Show InChI InChI=1S/C22H25N3O2/c1-17(14-18-5-6-19-20(26)7-13-27-21(19)15-18)16-24-9-11-25(12-10-24)22-4-2-3-8-23-22/h2-8,13,15,17H,9-12,14,16H2,1H3
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n/an/a 437n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory binding activity against Dopamine receptor in rat striatal membranes using [3H]HAL as the radioligand.


J Med Chem 34: 248-56 (1991)


Article DOI: 10.1021/jm00105a039
BindingDB Entry DOI: 10.7270/Q20Z73WT
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50228817
PNG
(CHEMBL83350)
Show SMILES O=c1ccoc2cc(OCCCN3CCCN(CC3)c3ccccc3)ccc12
Show InChI InChI=1S/C23H26N2O3/c26-22-10-17-28-23-18-20(8-9-21(22)23)27-16-5-12-24-11-4-13-25(15-14-24)19-6-2-1-3-7-19/h1-3,6-10,17-18H,4-5,11-16H2
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n/an/a 884n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory binding activity against Dopamine receptor in rat striatal membranes using [3H]HAL as the radioligand.


J Med Chem 34: 248-56 (1991)


Article DOI: 10.1021/jm00105a039
BindingDB Entry DOI: 10.7270/Q20Z73WT
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50007428
PNG
(7-[3-(4-Pyridin-2-yl-piperazin-1-yl)-propoxy]-chro...)
Show SMILES O=c1ccoc2cc(OCCCN3CCN(CC3)c3ccccn3)ccc12
Show InChI InChI=1S/C21H23N3O3/c25-19-7-15-27-20-16-17(5-6-18(19)20)26-14-3-9-23-10-12-24(13-11-23)21-4-1-2-8-22-21/h1-2,4-8,15-16H,3,9-14H2
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n/an/a 1.00E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for its inhibitory effect on the binding profile in 5-hydroxytryptamine 2 receptor using [3H]spiroperidol in rat brain.


J Med Chem 34: 248-56 (1991)


Article DOI: 10.1021/jm00105a039
BindingDB Entry DOI: 10.7270/Q20Z73WT
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50007428
PNG
(7-[3-(4-Pyridin-2-yl-piperazin-1-yl)-propoxy]-chro...)
Show SMILES O=c1ccoc2cc(OCCCN3CCN(CC3)c3ccccn3)ccc12
Show InChI InChI=1S/C21H23N3O3/c25-19-7-15-27-20-16-17(5-6-18(19)20)26-14-3-9-23-10-12-24(13-11-23)21-4-1-2-8-22-21/h1-2,4-8,15-16H,3,9-14H2
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n/an/a 1.00E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory binding activity against Dopamine receptor in rat striatal membranes using [3H]HAL as the radioligand.


J Med Chem 34: 248-56 (1991)


Article DOI: 10.1021/jm00105a039
BindingDB Entry DOI: 10.7270/Q20Z73WT
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50007428
PNG
(7-[3-(4-Pyridin-2-yl-piperazin-1-yl)-propoxy]-chro...)
Show SMILES O=c1ccoc2cc(OCCCN3CCN(CC3)c3ccccn3)ccc12
Show InChI InChI=1S/C21H23N3O3/c25-19-7-15-27-20-16-17(5-6-18(19)20)26-14-3-9-23-10-12-24(13-11-23)21-4-1-2-8-22-21/h1-2,4-8,15-16H,3,9-14H2
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n/an/a 1.08E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for its inhibitory effect on the binding profile in Dopamine receptor D2 using [3H]haloperidol in rat brain.


J Med Chem 34: 248-56 (1991)


Article DOI: 10.1021/jm00105a039
BindingDB Entry DOI: 10.7270/Q20Z73WT
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50007428
PNG
(7-[3-(4-Pyridin-2-yl-piperazin-1-yl)-propoxy]-chro...)
Show SMILES O=c1ccoc2cc(OCCCN3CCN(CC3)c3ccccn3)ccc12
Show InChI InChI=1S/C21H23N3O3/c25-19-7-15-27-20-16-17(5-6-18(19)20)26-14-3-9-23-10-12-24(13-11-23)21-4-1-2-8-22-21/h1-2,4-8,15-16H,3,9-14H2
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n/an/a 2.60E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for its inhibitory effect on the binding profile in Alpha-2 adrenergic receptor using [3H]p-aminoclonidine in rat brain.


J Med Chem 34: 248-56 (1991)


Article DOI: 10.1021/jm00105a039
BindingDB Entry DOI: 10.7270/Q20Z73WT
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50007428
PNG
(7-[3-(4-Pyridin-2-yl-piperazin-1-yl)-propoxy]-chro...)
Show SMILES O=c1ccoc2cc(OCCCN3CCN(CC3)c3ccccn3)ccc12
Show InChI InChI=1S/C21H23N3O3/c25-19-7-15-27-20-16-17(5-6-18(19)20)26-14-3-9-23-10-12-24(13-11-23)21-4-1-2-8-22-21/h1-2,4-8,15-16H,3,9-14H2
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n/an/a 2.17E+4n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for its inhibitory effect on the binding profile in Dopamine receptor D1 using [3H]flupenthixol in rat brain.


J Med Chem 34: 248-56 (1991)


Article DOI: 10.1021/jm00105a039
BindingDB Entry DOI: 10.7270/Q20Z73WT
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%