Compile Data Set for Download or QSAR
maximum 50k data
Found 25 Enz. Inhib. hit(s) with all data for entry = 50017908
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188311(2-(3-(8-chloroquinolin-4-yl)-2,5-dimethyl-1H-indol...)
Affinity DataIC50:  2.30nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188301(2-(2,5-dimethyl-3-(8-methylquinolin-4-yl)-1H-indol...)
Affinity DataIC50:  2.60nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188300(2-(2,5-dimethyl-3-(7-(trifluoromethyl)quinolin-4-y...)
Affinity DataIC50:  5.40nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188305(2-(2,5-dimethyl-3-(8-(trifluoromethyl)quinolin-4-y...)
Affinity DataIC50:  6nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188309(2-(3-(8-fluoroquinolin-4-yl)-2,5-dimethyl-1H-indol...)
Affinity DataIC50:  7.10nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188307(2-(3-(7-chloroquinolin-4-yl)-2,5-dimethyl-1H-indol...)
Affinity DataIC50:  8nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188299(2-(3-(8-methoxyquinolin-4-yl)-2,5-dimethyl-1H-indo...)
Affinity DataIC50:  11nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188308(2-(3-(8-cyanoquinolin-4-yl)-2,5-dimethyl-1H-indol-...)
Affinity DataIC50:  18nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188314(2-(2,5-dimethyl-3-(2-methylquinolin-4-yl)-1H-indol...)
Affinity DataIC50:  18nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188313(2-(2,5-dimethyl-3-(quinolin-4-yl)-1H-indol-1-yl)ac...)
Affinity DataIC50:  21nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188310(2-(2,5-dimethyl-3-(8-(methylsulfonyl)quinolin-4-yl...)
Affinity DataIC50:  23nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188302(2-(1-(7-chloroquinolin-4-yl)-5-methoxy-2-methyl-1H...)
Affinity DataIC50:  40nMAssay Description:Inhibition of COX1-mediated platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188304(2-(3-(7-chloroquinolin-4-yl)-5-methoxy-2-methyl-1H...)
Affinity DataIC50:  50nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188306(2-(2,5-dimethyl-3-(6-(trifluoromethyl)quinolin-4-y...)
Affinity DataIC50:  68nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188312(2-(3-(7-chloroquinolin-4-yl)-2,6-dimethyl-1H-indol...)
Affinity DataIC50:  125nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188301(2-(2,5-dimethyl-3-(8-methylquinolin-4-yl)-1H-indol...)
Affinity DataIC50:  150nMAssay Description:Inhibition at rat aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188302(2-(1-(7-chloroquinolin-4-yl)-5-methoxy-2-methyl-1H...)
Affinity DataIC50:  180nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188307(2-(3-(7-chloroquinolin-4-yl)-2,5-dimethyl-1H-indol...)
Affinity DataIC50:  400nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188302(2-(1-(7-chloroquinolin-4-yl)-5-methoxy-2-methyl-1H...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition at recombinant human CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188301(2-(2,5-dimethyl-3-(8-methylquinolin-4-yl)-1H-indol...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition at rat serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188301(2-(2,5-dimethyl-3-(8-methylquinolin-4-yl)-1H-indol...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition at recombinant human CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188301(2-(2,5-dimethyl-3-(8-methylquinolin-4-yl)-1H-indol...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188301(2-(2,5-dimethyl-3-(8-methylquinolin-4-yl)-1H-indol...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188301(2-(2,5-dimethyl-3-(8-methylquinolin-4-yl)-1H-indol...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition at CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188303(2-(2-methyl-1-(pyrimidin-4-yl)-1H-indol-3-yl)aceti...)
Affinity DataIC50:  5.20E+3nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed