Compile Data Set for Download or QSAR
maximum 50k data
Found 65 Enz. Inhib. hit(s) with all data for entry = 50017958
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189188(3-amino-N-((1S)-1-(2-(4-(3-(2,4-dichlorophenyl)pro...)
Affinity DataKi:  13nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189232(2-amino-N-((1S)-1-(2-(4-(3-(2,4-dichlorophenyl)pro...)
Affinity DataKi:  18nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189210((S)-2-amino-N-(1-(2-(4-(3-(2,4-dichlorophenyl)prop...)
Affinity DataKi:  19nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189202((S)-3-amino-N-(1-(2-(4-(3-(2,4-dichlorophenyl)prop...)
Affinity DataKi:  25nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189223(1-(4-(2-((1S)-1-(3-aminopropylamino)-2-methylbutyl...)
Affinity DataKi:  30nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189200(1-(4-(2-((1S)-1-(2-aminoethylamino)-2-methylbutyl)...)
Affinity DataKi:  56nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189192(1-(4-(2-((1S)-1-amino-2-methylbutyl)-4-(trifluorom...)
Affinity DataKi:  57nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189217(3-(2,4-dichlorophenyl)-1-(4-(2-((1S)-2-methyl-1-((...)
Affinity DataKi:  64nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189237((1S)-[2-{4-[3-(2,4-dichlorophenyl)propionyl]-1-pip...)
Affinity DataKi:  74nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189211(1-(4-(2-((2S)-1-amino-2-methylbutyl)-4-(trifluorom...)
Affinity DataKi:  75nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189231(1-(4-(2-((1S)-1-amino-2-methylbutyl)-4-(trifluorom...)
Affinity DataKi:  86nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189234(1-(4-(2-((1S)-1-((S)-2-aminopropylamino)-2-methylb...)
Affinity DataKi:  89nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189208(3-(2,4-dichlorophenyl)-1-(4-(2-((1S)-1-(ethylamino...)
Affinity DataKi:  92nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189193((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-fluorophenyl...)
Affinity DataKi:  94nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189183((S)-1-(4-(2-(1-amino-3-methylbutyl)-6-fluorophenyl...)
Affinity DataKi:  110nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189205(3-(2,4-dichlorophenyl)-1-(4-(2-((1S)-2-methyl-1-((...)
Affinity DataKi:  110nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189229(1-(4-(2-(1-amino-2-methylpropyl)-4-(trifluoromethy...)
Affinity DataKi:  140nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189235(1-(4-(2-(1-amino-2-methylbutyl)-4-(trifluoromethyl...)
Affinity DataKi:  160nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189188(3-amino-N-((1S)-1-(2-(4-(3-(2,4-dichlorophenyl)pro...)
Affinity DataKi:  170nMAssay Description:Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189206((S)-3-(2,4-dichlorophenyl)-1-(4-(2-(1-(ethylamino)...)
Affinity DataKi:  170nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189236(1-(4-(2-(1-aminopentyl)-4-(trifluoromethyl)phenyl)...)
Affinity DataKi:  190nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189221(3-amino-N-(2-(benzyloxy)-1-(2-(4-(3-(2,4-dichlorop...)
Affinity DataKi:  210nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189222(3-amino-N-(1-(2-(4-(3-(2,4-dichlorophenyl)propanoy...)
Affinity DataKi:  300nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189219((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Affinity DataKi:  350nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189194(CHEMBL212303 | N-((1S)-1-(2-(4-(3-(2,4-dichlorophe...)
Affinity DataKi:  360nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189218(1-(4-(2-(1-(2-aminoethylamino)-2-(benzyloxy)ethyl)...)
Affinity DataKi:  400nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189214(1-(4-(2-(1-aminoethyl)-4-(trifluoromethyl)phenyl)p...)
Affinity DataKi:  490nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189210((S)-2-amino-N-(1-(2-(4-(3-(2,4-dichlorophenyl)prop...)
Affinity DataKi:  500nMAssay Description:Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189191((S)-3-(2,4-dichlorophenyl)-1-(4-(2-(1-(2-methoxyet...)
Affinity DataKi:  620nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189224((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Affinity DataKi:  640nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189195(1-(4-(2-(1-amino-2-ethoxyethyl)-4-fluorophenyl)pip...)
Affinity DataKi:  690nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189197(3-(2,4-dichlorophenyl)-1-(4-(2-((1S)-2-methyl-1-((...)
Affinity DataKi:  780nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189188(3-amino-N-((1S)-1-(2-(4-(3-(2,4-dichlorophenyl)pro...)
Affinity DataKi:  800nMAssay Description:Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189189(1-(4-(2-(1-amino-2-(benzyloxy)ethyl)-4-fluoropheny...)
Affinity DataKi:  1.00E+3nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189210((S)-2-amino-N-(1-(2-(4-(3-(2,4-dichlorophenyl)prop...)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189183((S)-1-(4-(2-(1-amino-3-methylbutyl)-6-fluorophenyl...)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189183((S)-1-(4-(2-(1-amino-3-methylbutyl)-6-fluorophenyl...)
Affinity DataKi:  1.40E+3nMAssay Description:Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189190((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Affinity DataKi:  1.40E+3nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189182((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Affinity DataKi:  1.50E+3nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189196((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Affinity DataKi:  1.60E+3nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189213((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Affinity DataKi:  1.70E+3nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189212(CHEMBL212553 | N-((1S)-1-(2-(4-(3-(2,4-dichlorophe...)
Affinity DataKi:  1.80E+3nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189209((S)-3-(2,4-dichlorophenyl)-1-(4-(2-(3-methyl-1-(me...)
Affinity DataKi:  1.90E+3nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189215((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Affinity DataKi:  2.10E+3nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189226((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Affinity DataKi:  2.20E+3nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189198((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Affinity DataKi:  2.30E+3nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189186(CHEMBL213935 | methyl (1S)-1-(2-(4-(3-(2,4-dichlor...)
Affinity DataKi:  2.40E+3nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189230(1-(4-(2-((1S)-1-amino-2-methylbutyl)-4-(trifluorom...)
Affinity DataKi:  2.50E+3nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189228((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Affinity DataKi:  2.50E+3nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189227((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Affinity DataKi:  2.60E+3nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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