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Found 13 Enz. Inhib. hit(s) with all data for entry = 50018053
TargetOxytocin receptor(Homo sapiens (Human))
Cardiovascular And Urogenital Centre Of Excellence For Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50190528((2R)-2-(2,4-difluorophenyl)-2-[(3R,6R)-3-(2,3-dihy...)
Affinity DataIC50:  3.70nMAssay Description:Agonist activity at human OTR expressed in CHO cells assessed as inhibition of oxytocin-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Cardiovascular And Urogenital Centre Of Excellence For Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50190529((2R)-2-(1-benzofuran-5-yl)-2-[(3R,6R)-3-(2,3-dihyd...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of CYP450 3A4 transfected in human microsome using DEF fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Cardiovascular And Urogenital Centre Of Excellence For Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50190529((2R)-2-(1-benzofuran-5-yl)-2-[(3R,6R)-3-(2,3-dihyd...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of CYP450 2C9 transfected in human microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Cardiovascular And Urogenital Centre Of Excellence For Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50190529((2R)-2-(1-benzofuran-5-yl)-2-[(3R,6R)-3-(2,3-dihyd...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of CYP450 3A4 transfected in human microsome using PPR fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Cardiovascular And Urogenital Centre Of Excellence For Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50190528((2R)-2-(2,4-difluorophenyl)-2-[(3R,6R)-3-(2,3-dihy...)
Affinity DataIC50:  4.90E+4nMAssay Description:Inhibition of CYP450 2C9 transfected in human microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Cardiovascular And Urogenital Centre Of Excellence For Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50190529((2R)-2-(1-benzofuran-5-yl)-2-[(3R,6R)-3-(2,3-dihyd...)
Affinity DataIC50:  6.20E+4nMAssay Description:Inhibition of CYP450 2D6 transfected in human microsome using DEF fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Cardiovascular And Urogenital Centre Of Excellence For Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50190528((2R)-2-(2,4-difluorophenyl)-2-[(3R,6R)-3-(2,3-dihy...)
Affinity DataIC50:  6.20E+4nMAssay Description:Inhibition of CYP450 3A4 transfected in human microsome using PPR fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Cardiovascular And Urogenital Centre Of Excellence For Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50190528((2R)-2-(2,4-difluorophenyl)-2-[(3R,6R)-3-(2,3-dihy...)
Affinity DataIC50:  6.40E+4nMAssay Description:Inhibition of CYP450 1A2 transfected in human microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Cardiovascular And Urogenital Centre Of Excellence For Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50190529((2R)-2-(1-benzofuran-5-yl)-2-[(3R,6R)-3-(2,3-dihyd...)
Affinity DataIC50:  7.30E+4nMAssay Description:Inhibition of CYP450 1A2 transfected in human microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Cardiovascular And Urogenital Centre Of Excellence For Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50190528((2R)-2-(2,4-difluorophenyl)-2-[(3R,6R)-3-(2,3-dihy...)
Affinity DataIC50:  8.90E+4nMAssay Description:Inhibition of CYP450 3A4 transfected in human microsome using DEF fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Cardiovascular And Urogenital Centre Of Excellence For Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50190528((2R)-2-(2,4-difluorophenyl)-2-[(3R,6R)-3-(2,3-dihy...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP450 2C19 transfected in human microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Cardiovascular And Urogenital Centre Of Excellence For Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50190529((2R)-2-(1-benzofuran-5-yl)-2-[(3R,6R)-3-(2,3-dihyd...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP450 2C19 transfected in human microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Cardiovascular And Urogenital Centre Of Excellence For Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50190528((2R)-2-(2,4-difluorophenyl)-2-[(3R,6R)-3-(2,3-dihy...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP450 2D6 transfected in human microsome using DEF fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed