Compile Data Set for Download or QSAR
maximum 50k data
Found 54 Enz. Inhib. hit(s) with all data for entry = 50018135
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191801((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50:  3nMAssay Description:Activity at CCR2b by calcium flux based FLIPR assay in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191818((2S)-N-[3,5-bis(trifluoromethyl)benzyl]-2-cyclopro...)
Affinity DataIC50:  4nMAssay Description:Activity at CCR2b by calcium flux based FLIPR assay in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191818((2S)-N-[3,5-bis(trifluoromethyl)benzyl]-2-cyclopro...)
Affinity DataIC50:  4nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191801((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50:  9nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191802((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50:  11nMAssay Description:Activity at CCR2b by calcium flux based FLIPR assay in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191802((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50:  12nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191823((2R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50:  13nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191818((2S)-N-[3,5-bis(trifluoromethyl)benzyl]-2-cyclopro...)
Affinity DataIC50:  14nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191800((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50:  15nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191801((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50:  25nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191802((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50:  28nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191812((2R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50:  37nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191803((2R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50:  37nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191798(CHEMBL215654 | N-{[3,5-bis(trifluoromethyl)phenyl]...)
Affinity DataIC50:  38nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191805((R)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(4-phe...)
Affinity DataIC50:  42nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191820((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-3-...)
Affinity DataIC50:  47nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191815(CHEMBL214825 | N-{[3,5-bis(trifluoromethyl)phenyl]...)
Affinity DataIC50:  48nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191814((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50:  67nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191798(CHEMBL215654 | N-{[3,5-bis(trifluoromethyl)phenyl]...)
Affinity DataIC50:  69nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191817((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-cycloprop...)
Affinity DataIC50:  72nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191807((2R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-3-...)
Affinity DataIC50:  72nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191821(CHEMBL214747 | N-{[3,5-bis(trifluoromethyl)phenyl]...)
Affinity DataIC50:  73nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191823((2R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50:  80nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191813((2S)-N-[3,5-bis(trifluoromethyl)benzyl]-2-(4-fluor...)
Affinity DataIC50:  80nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191799(2-(1-acetylpiperidin-3-yl)-N-{[3,5-bis(trifluorome...)
Affinity DataIC50:  80nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191806((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50:  86nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191816(CHEMBL409162 | N-{[3,5-bis(trifluoromethyl)phenyl]...)
Affinity DataIC50:  93nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191800((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50:  98nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191811(CHEMBL211923 | N-{[3,5-bis(trifluoromethyl)phenyl]...)
Affinity DataIC50:  125nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191805((R)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(4-phe...)
Affinity DataIC50:  126nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191808((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-cycloprop...)
Affinity DataIC50:  129nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191821(CHEMBL214747 | N-{[3,5-bis(trifluoromethyl)phenyl]...)
Affinity DataIC50:  160nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191816(CHEMBL409162 | N-{[3,5-bis(trifluoromethyl)phenyl]...)
Affinity DataIC50:  173nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187053((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(4-fluoro...)
Affinity DataIC50:  180nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191803((2R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50:  193nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191820((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-3-...)
Affinity DataIC50:  204nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191809((R)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(4-phe...)
Affinity DataIC50:  216nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191812((2R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50:  231nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191819(2-benzyl-N-{[3,5-bis(trifluoromethyl)phenyl]methyl...)
Affinity DataIC50:  232nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191804(CHEMBL212542 | N-{[3,5-bis(trifluoromethyl)phenyl]...)
Affinity DataIC50:  244nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191817((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-cycloprop...)
Affinity DataIC50:  280nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191808((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-cycloprop...)
Affinity DataIC50:  285nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191819(2-benzyl-N-{[3,5-bis(trifluoromethyl)phenyl]methyl...)
Affinity DataIC50:  298nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191807((2R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-3-...)
Affinity DataIC50:  349nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191822((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-4-...)
Affinity DataIC50:  437nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191825(CHEMBL377819 | N-(3,5-bis(trifluoromethyl)benzyl)-...)
Affinity DataIC50:  462nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191827(CHEMBL378258 | N-{[3,5-bis(trifluoromethyl)phenyl]...)
Affinity DataIC50:  525nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191826(CHEMBL378449 | N-{[3,5-bis(trifluoromethyl)phenyl]...)
Affinity DataIC50:  570nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191806((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50:  605nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191809((R)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(4-phe...)
Affinity DataIC50:  642nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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