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PubMed code 17125266

Compile data set for download or QSAR
Found 72 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50392637
PNG
(CHEMBL215421)
Show SMILES COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1
Show InChI InChI=1S/C19H23NO5/c1-21-17-8-5-9-18(22-2)19(17)23-11-10-20-12-14-13-24-15-6-3-4-7-16(15)25-14/h3-9,14,20H,10-13H2,1-2H3/t14-/m0/s1
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PubMed
0.410n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1A receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(HUMAN)
BDBM50392637
PNG
(CHEMBL215421)
Show SMILES COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1
Show InChI InChI=1S/C19H23NO5/c1-21-17-8-5-9-18(22-2)19(17)23-11-10-20-12-14-13-24-15-6-3-4-7-16(15)25-14/h3-9,14,20H,10-13H2,1-2H3/t14-/m0/s1
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0.510n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50411193
PNG
(CHEMBL215151)
Show SMILES COc1cccc(-c2ccccc2)c1OCCNC[C@H]1COc2ccccc2O1
Show InChI InChI=1S/C24H25NO4/c1-26-23-13-7-10-20(18-8-3-2-4-9-18)24(23)27-15-14-25-16-19-17-28-21-11-5-6-12-22(21)29-19/h2-13,19,25H,14-17H2,1H3/t19-/m0/s1
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1.20n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1A receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50411188
PNG
(CHEMBL217469)
Show SMILES COc1ccc2ccccc2c1OCCNC[C@H]1COc2ccccc2O1
Show InChI InChI=1S/C22H23NO4/c1-24-21-11-10-16-6-2-3-7-18(16)22(21)25-13-12-23-14-17-15-26-19-8-4-5-9-20(19)27-17/h2-11,17,23H,12-15H2,1H3/t17-/m0/s1
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1.60n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1A receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50392637
PNG
(CHEMBL215421)
Show SMILES COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1
Show InChI InChI=1S/C19H23NO5/c1-21-17-8-5-9-18(22-2)19(17)23-11-10-20-12-14-13-24-15-6-3-4-7-16(15)25-14/h3-9,14,20H,10-13H2,1-2H3/t14-/m0/s1
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2.5n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat hippocampus


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50411194
PNG
(CHEMBL383938)
Show SMILES COc1ccc2CCCCc2c1OCCNC[C@H]1COc2ccccc2O1
Show InChI InChI=1S/C22H27NO4/c1-24-21-11-10-16-6-2-3-7-18(16)22(21)25-13-12-23-14-17-15-26-19-8-4-5-9-20(19)27-17/h4-5,8-11,17,23H,2-3,6-7,12-15H2,1H3/t17-/m0/s1
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2.80n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1A receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(HUMAN)
BDBM50411193
PNG
(CHEMBL215151)
Show SMILES COc1cccc(-c2ccccc2)c1OCCNC[C@H]1COc2ccccc2O1
Show InChI InChI=1S/C24H25NO4/c1-26-23-13-7-10-20(18-8-3-2-4-9-18)24(23)27-15-14-25-16-19-17-28-21-11-5-6-12-22(21)29-19/h2-13,19,25H,14-17H2,1H3/t19-/m0/s1
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3.40n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50411187
PNG
(CHEMBL439346)
Show SMILES COc1ccc2ccccc2c1OCCNC[C@@H]1COc2ccccc2O1
Show InChI InChI=1S/C22H23NO4/c1-24-21-11-10-16-6-2-3-7-18(16)22(21)25-13-12-23-14-17-15-26-19-8-4-5-9-20(19)27-17/h2-11,17,23H,12-15H2,1H3/t17-/m1/s1
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4.60n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1A receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50411195
PNG
(CHEMBL214694)
Show SMILES COc1ccc(cc1OCCNC[C@H]1COc2ccccc2O1)-c1ccccc1
Show InChI InChI=1S/C24H25NO4/c1-26-21-12-11-19(18-7-3-2-4-8-18)15-24(21)27-14-13-25-16-20-17-28-22-9-5-6-10-23(22)29-20/h2-12,15,20,25H,13-14,16-17H2,1H3/t20-/m0/s1
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5.60n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1A receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50392637
PNG
(CHEMBL215421)
Show SMILES COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1
Show InChI InChI=1S/C19H23NO5/c1-21-17-8-5-9-18(22-2)19(17)23-11-10-20-12-14-13-24-15-6-3-4-7-16(15)25-14/h3-9,14,20H,10-13H2,1-2H3/t14-/m0/s1
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5.80n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1B receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(HUMAN)
BDBM50411188
PNG
(CHEMBL217469)
Show SMILES COc1ccc2ccccc2c1OCCNC[C@H]1COc2ccccc2O1
Show InChI InChI=1S/C22H23NO4/c1-24-21-11-10-16-6-2-3-7-18(16)22(21)25-13-12-23-14-17-15-26-19-8-4-5-9-20(19)27-17/h2-11,17,23H,12-15H2,1H3/t17-/m0/s1
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6.60n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50411193
PNG
(CHEMBL215151)
Show SMILES COc1cccc(-c2ccccc2)c1OCCNC[C@H]1COc2ccccc2O1
Show InChI InChI=1S/C24H25NO4/c1-26-23-13-7-10-20(18-8-3-2-4-9-18)24(23)27-15-14-25-16-19-17-28-21-11-5-6-12-22(21)29-19/h2-13,19,25H,14-17H2,1H3/t19-/m0/s1
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6.90n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat hippocampus


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50411194
PNG
(CHEMBL383938)
Show SMILES COc1ccc2CCCCc2c1OCCNC[C@H]1COc2ccccc2O1
Show InChI InChI=1S/C22H27NO4/c1-24-21-11-10-16-6-2-3-7-18(16)22(21)25-13-12-23-14-17-15-26-19-8-4-5-9-20(19)27-17/h4-5,8-11,17,23H,2-3,6-7,12-15H2,1H3/t17-/m0/s1
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8.5n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat hippocampus


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50002735
PNG
(CHEMBL214952)
Show SMILES COc1cccc(-c2ccccc2)c1OCCNC[C@@H]1COc2ccccc2O1
Show InChI InChI=1S/C24H25NO4.ClH/c1-26-23-13-7-10-20(18-8-3-2-4-9-18)24(23)27-15-14-25-16-19-17-28-21-11-5-6-12-22(21)29-19;/h2-13,19,25H,14-17H2,1H3;1H/t19-;/m1./s1
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9.30n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1A receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(HUMAN)
BDBM50392638
PNG
(CHEMBL214986)
Show SMILES COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1
Show InChI InChI=1S/C19H23NO5/c1-21-17-8-5-9-18(22-2)19(17)23-11-10-20-12-14-13-24-15-6-3-4-7-16(15)25-14/h3-9,14,20H,10-13H2,1-2H3/t14-/m1/s1
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10n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50411195
PNG
(CHEMBL214694)
Show SMILES COc1ccc(cc1OCCNC[C@H]1COc2ccccc2O1)-c1ccccc1
Show InChI InChI=1S/C24H25NO4/c1-26-21-12-11-19(18-7-3-2-4-8-18)15-24(21)27-14-13-25-16-20-17-28-22-9-5-6-10-23(22)29-20/h2-12,15,20,25H,13-14,16-17H2,1H3/t20-/m0/s1
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11n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1B receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50411188
PNG
(CHEMBL217469)
Show SMILES COc1ccc2ccccc2c1OCCNC[C@H]1COc2ccccc2O1
Show InChI InChI=1S/C22H23NO4/c1-24-21-11-10-16-6-2-3-7-18(16)22(21)25-13-12-23-14-17-15-26-19-8-4-5-9-20(19)27-17/h2-11,17,23H,12-15H2,1H3/t17-/m0/s1
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11n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat hippocampus


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50392638
PNG
(CHEMBL214986)
Show SMILES COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1
Show InChI InChI=1S/C19H23NO5/c1-21-17-8-5-9-18(22-2)19(17)23-11-10-20-12-14-13-24-15-6-3-4-7-16(15)25-14/h3-9,14,20H,10-13H2,1-2H3/t14-/m1/s1
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11n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1A receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50002732
PNG
(CHEMBL217143)
Show SMILES COc1ccc2CCCCc2c1OCCNC[C@@H]1COc2ccccc2O1
Show InChI InChI=1S/C22H27NO4.ClH/c1-24-21-11-10-16-6-2-3-7-18(16)22(21)25-13-12-23-14-17-15-26-19-8-4-5-9-20(19)27-17;/h4-5,8-11,17,23H,2-3,6-7,12-15H2,1H3;1H/t17-;/m1./s1
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11n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1A receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(HUMAN)
BDBM50411194
PNG
(CHEMBL383938)
Show SMILES COc1ccc2CCCCc2c1OCCNC[C@H]1COc2ccccc2O1
Show InChI InChI=1S/C22H27NO4/c1-24-21-11-10-16-6-2-3-7-18(16)22(21)25-13-12-23-14-17-15-26-19-8-4-5-9-20(19)27-17/h4-5,8-11,17,23H,2-3,6-7,12-15H2,1H3/t17-/m0/s1
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14n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(HUMAN)
BDBM50411195
PNG
(CHEMBL214694)
Show SMILES COc1ccc(cc1OCCNC[C@H]1COc2ccccc2O1)-c1ccccc1
Show InChI InChI=1S/C24H25NO4/c1-26-21-12-11-19(18-7-3-2-4-8-18)15-24(21)27-14-13-25-16-20-17-28-22-9-5-6-10-23(22)29-20/h2-12,15,20,25H,13-14,16-17H2,1H3/t20-/m0/s1
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15n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50002733
PNG
(CHEMBL214552)
Show SMILES COc1ccc(cc1OCCNC[C@@H]1COc2ccccc2O1)-c1ccccc1
Show InChI InChI=1S/C24H25NO4.ClH/c1-26-21-12-11-19(18-7-3-2-4-8-18)15-24(21)27-14-13-25-16-20-17-28-22-9-5-6-10-23(22)29-20;/h2-12,15,20,25H,13-14,16-17H2,1H3;1H/t20-;/m1./s1
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16n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1A receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50411188
PNG
(CHEMBL217469)
Show SMILES COc1ccc2ccccc2c1OCCNC[C@H]1COc2ccccc2O1
Show InChI InChI=1S/C22H23NO4/c1-24-21-11-10-16-6-2-3-7-18(16)22(21)25-13-12-23-14-17-15-26-19-8-4-5-9-20(19)27-17/h2-11,17,23H,12-15H2,1H3/t17-/m0/s1
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16n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1B receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(HUMAN)
BDBM50002732
PNG
(CHEMBL217143)
Show SMILES COc1ccc2CCCCc2c1OCCNC[C@@H]1COc2ccccc2O1
Show InChI InChI=1S/C22H27NO4.ClH/c1-24-21-11-10-16-6-2-3-7-18(16)22(21)25-13-12-23-14-17-15-26-19-8-4-5-9-20(19)27-17;/h4-5,8-11,17,23H,2-3,6-7,12-15H2,1H3;1H/t17-;/m1./s1
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16n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50411193
PNG
(CHEMBL215151)
Show SMILES COc1cccc(-c2ccccc2)c1OCCNC[C@H]1COc2ccccc2O1
Show InChI InChI=1S/C24H25NO4/c1-26-23-13-7-10-20(18-8-3-2-4-9-18)24(23)27-15-14-25-16-19-17-28-21-11-5-6-12-22(21)29-19/h2-13,19,25H,14-17H2,1H3/t19-/m0/s1
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18n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1B receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50411194
PNG
(CHEMBL383938)
Show SMILES COc1ccc2CCCCc2c1OCCNC[C@H]1COc2ccccc2O1
Show InChI InChI=1S/C22H27NO4/c1-24-21-11-10-16-6-2-3-7-18(16)22(21)25-13-12-23-14-17-15-26-19-8-4-5-9-20(19)27-17/h4-5,8-11,17,23H,2-3,6-7,12-15H2,1H3/t17-/m0/s1
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19n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1B receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(HUMAN)
BDBM50411187
PNG
(CHEMBL439346)
Show SMILES COc1ccc2ccccc2c1OCCNC[C@@H]1COc2ccccc2O1
Show InChI InChI=1S/C22H23NO4/c1-24-21-11-10-16-6-2-3-7-18(16)22(21)25-13-12-23-14-17-15-26-19-8-4-5-9-20(19)27-17/h2-11,17,23H,12-15H2,1H3/t17-/m1/s1
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22n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50411189
PNG
(CHEMBL218079)
Show SMILES COc1cccc(OC)c1OCCNC[C@H]1COc2cc3CCCCc3cc2O1
Show InChI InChI=1S/C23H29NO5/c1-25-19-8-5-9-20(26-2)23(19)27-11-10-24-14-18-15-28-21-12-16-6-3-4-7-17(16)13-22(21)29-18/h5,8-9,12-13,18,24H,3-4,6-7,10-11,14-15H2,1-2H3/t18-/m0/s1
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25n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1A receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(HUMAN)
BDBM50002735
PNG
(CHEMBL214952)
Show SMILES COc1cccc(-c2ccccc2)c1OCCNC[C@@H]1COc2ccccc2O1
Show InChI InChI=1S/C24H25NO4.ClH/c1-26-23-13-7-10-20(18-8-3-2-4-9-18)24(23)27-15-14-25-16-19-17-28-21-11-5-6-12-22(21)29-19;/h2-13,19,25H,14-17H2,1H3;1H/t19-;/m1./s1
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29n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50411190
PNG
(CHEMBL215188)
Show SMILES COc1cccc(OC)c1OCCNC[C@H]1COc2cc3ccccc3cc2O1
Show InChI InChI=1S/C23H25NO5/c1-25-19-8-5-9-20(26-2)23(19)27-11-10-24-14-18-15-28-21-12-16-6-3-4-7-17(16)13-22(21)29-18/h3-9,12-13,18,24H,10-11,14-15H2,1-2H3/t18-/m0/s1
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34n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1A receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50392638
PNG
(CHEMBL214986)
Show SMILES COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1
Show InChI InChI=1S/C19H23NO5/c1-21-17-8-5-9-18(22-2)19(17)23-11-10-20-12-14-13-24-15-6-3-4-7-16(15)25-14/h3-9,14,20H,10-13H2,1-2H3/t14-/m1/s1
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41n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat hippocampus


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50002732
PNG
(CHEMBL217143)
Show SMILES COc1ccc2CCCCc2c1OCCNC[C@@H]1COc2ccccc2O1
Show InChI InChI=1S/C22H27NO4.ClH/c1-24-21-11-10-16-6-2-3-7-18(16)22(21)25-13-12-23-14-17-15-26-19-8-4-5-9-20(19)27-17;/h4-5,8-11,17,23H,2-3,6-7,12-15H2,1H3;1H/t17-;/m1./s1
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49n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1B receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50411195
PNG
(CHEMBL214694)
Show SMILES COc1ccc(cc1OCCNC[C@H]1COc2ccccc2O1)-c1ccccc1
Show InChI InChI=1S/C24H25NO4/c1-26-21-12-11-19(18-7-3-2-4-8-18)15-24(21)27-14-13-25-16-20-17-28-22-9-5-6-10-23(22)29-20/h2-12,15,20,25H,13-14,16-17H2,1H3/t20-/m0/s1
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52n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat hippocampus


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(HUMAN)
BDBM50002733
PNG
(CHEMBL214552)
Show SMILES COc1ccc(cc1OCCNC[C@@H]1COc2ccccc2O1)-c1ccccc1
Show InChI InChI=1S/C24H25NO4.ClH/c1-26-21-12-11-19(18-7-3-2-4-8-18)15-24(21)27-14-13-25-16-20-17-28-22-9-5-6-10-23(22)29-20;/h2-12,15,20,25H,13-14,16-17H2,1H3;1H/t20-;/m1./s1
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54n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50002733
PNG
(CHEMBL214552)
Show SMILES COc1ccc(cc1OCCNC[C@@H]1COc2ccccc2O1)-c1ccccc1
Show InChI InChI=1S/C24H25NO4.ClH/c1-26-21-12-11-19(18-7-3-2-4-8-18)15-24(21)27-14-13-25-16-20-17-28-22-9-5-6-10-23(22)29-20;/h2-12,15,20,25H,13-14,16-17H2,1H3;1H/t20-;/m1./s1
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62n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1B receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50411192
PNG
(CHEMBL385371)
Show SMILES COc1ccc2ccccc2c1OCCNC[C@H]1COc2cc3CCCCc3cc2O1
Show InChI InChI=1S/C26H29NO4/c1-28-23-11-10-18-6-4-5-9-22(18)26(23)29-13-12-27-16-21-17-30-24-14-19-7-2-3-8-20(19)15-25(24)31-21/h4-6,9-11,14-15,21,27H,2-3,7-8,12-13,16-17H2,1H3/t21-/m0/s1
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66n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1A receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50411187
PNG
(CHEMBL439346)
Show SMILES COc1ccc2ccccc2c1OCCNC[C@@H]1COc2ccccc2O1
Show InChI InChI=1S/C22H23NO4/c1-24-21-11-10-16-6-2-3-7-18(16)22(21)25-13-12-23-14-17-15-26-19-8-4-5-9-20(19)27-17/h2-11,17,23H,12-15H2,1H3/t17-/m1/s1
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68n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat hippocampus


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50392638
PNG
(CHEMBL214986)
Show SMILES COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1
Show InChI InChI=1S/C19H23NO5/c1-21-17-8-5-9-18(22-2)19(17)23-11-10-20-12-14-13-24-15-6-3-4-7-16(15)25-14/h3-9,14,20H,10-13H2,1-2H3/t14-/m1/s1
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72n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1B receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50411191
PNG
(CHEMBL214762)
Show SMILES COc1cc(ccc1OCCNC[C@H]1COc2ccccc2O1)-c1ccccc1
Show InChI InChI=1S/C24H25NO4/c1-26-24-15-19(18-7-3-2-4-8-18)11-12-22(24)27-14-13-25-16-20-17-28-21-9-5-6-10-23(21)29-20/h2-12,15,20,25H,13-14,16-17H2,1H3/t20-/m0/s1
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74n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat hippocampus


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50002735
PNG
(CHEMBL214952)
Show SMILES COc1cccc(-c2ccccc2)c1OCCNC[C@@H]1COc2ccccc2O1
Show InChI InChI=1S/C24H25NO4.ClH/c1-26-23-13-7-10-20(18-8-3-2-4-9-18)24(23)27-15-14-25-16-19-17-28-21-11-5-6-12-22(21)29-19;/h2-13,19,25H,14-17H2,1H3;1H/t19-;/m1./s1
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78n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat hippocampus


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50411187
PNG
(CHEMBL439346)
Show SMILES COc1ccc2ccccc2c1OCCNC[C@@H]1COc2ccccc2O1
Show InChI InChI=1S/C22H23NO4/c1-24-21-11-10-16-6-2-3-7-18(16)22(21)25-13-12-23-14-17-15-26-19-8-4-5-9-20(19)27-17/h2-11,17,23H,12-15H2,1H3/t17-/m1/s1
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85n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1B receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50411191
PNG
(CHEMBL214762)
Show SMILES COc1cc(ccc1OCCNC[C@H]1COc2ccccc2O1)-c1ccccc1
Show InChI InChI=1S/C24H25NO4/c1-26-24-15-19(18-7-3-2-4-8-18)11-12-22(24)27-14-13-25-16-20-17-28-21-9-5-6-10-23(21)29-20/h2-12,15,20,25H,13-14,16-17H2,1H3/t20-/m0/s1
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87n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1A receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50002729
PNG
(CHEMBL215857)
Show SMILES COc1cccc(OC)c1OCCNC[C@@H]1COc2cc3CCCCc3cc2O1
Show InChI InChI=1S/C23H29NO5.ClH/c1-25-19-8-5-9-20(26-2)23(19)27-11-10-24-14-18-15-28-21-12-16-6-3-4-7-17(16)13-22(21)29-18;/h5,8-9,12-13,18,24H,3-4,6-7,10-11,14-15H2,1-2H3;1H/t18-;/m1./s1
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100n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1A receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50002730
PNG
(CHEMBL436955)
Show SMILES Cl.COc1cccc(OC)c1OCCNC[C@@H]1COc2cc3ccccc3cc2O1
Show InChI InChI=1S/C23H25NO5.ClH/c1-25-19-8-5-9-20(26-2)23(19)27-11-10-24-14-18-15-28-21-12-16-6-3-4-7-17(16)13-22(21)29-18;/h3-9,12-13,18,24H,10-11,14-15H2,1-2H3;1H/t18-;/m1./s1
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102n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1A receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50002732
PNG
(CHEMBL217143)
Show SMILES COc1ccc2CCCCc2c1OCCNC[C@@H]1COc2ccccc2O1
Show InChI InChI=1S/C22H27NO4.ClH/c1-24-21-11-10-16-6-2-3-7-18(16)22(21)25-13-12-23-14-17-15-26-19-8-4-5-9-20(19)27-17;/h4-5,8-11,17,23H,2-3,6-7,12-15H2,1H3;1H/t17-;/m1./s1
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132n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat hippocampus


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(HUMAN)
BDBM50411192
PNG
(CHEMBL385371)
Show SMILES COc1ccc2ccccc2c1OCCNC[C@H]1COc2cc3CCCCc3cc2O1
Show InChI InChI=1S/C26H29NO4/c1-28-23-11-10-18-6-4-5-9-22(18)26(23)29-13-12-27-16-21-17-30-24-14-19-7-2-3-8-20(19)15-25(24)31-21/h4-6,9-11,14-15,21,27H,2-3,7-8,12-13,16-17H2,1H3/t21-/m0/s1
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148n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50002735
PNG
(CHEMBL214952)
Show SMILES COc1cccc(-c2ccccc2)c1OCCNC[C@@H]1COc2ccccc2O1
Show InChI InChI=1S/C24H25NO4.ClH/c1-26-23-13-7-10-20(18-8-3-2-4-9-18)24(23)27-15-14-25-16-19-17-28-21-11-5-6-12-22(21)29-19;/h2-13,19,25H,14-17H2,1H3;1H/t19-;/m1./s1
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151n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1B receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50411191
PNG
(CHEMBL214762)
Show SMILES COc1cc(ccc1OCCNC[C@H]1COc2ccccc2O1)-c1ccccc1
Show InChI InChI=1S/C24H25NO4/c1-26-24-15-19(18-7-3-2-4-8-18)11-12-22(24)27-14-13-25-16-20-17-28-21-9-5-6-10-23(21)29-20/h2-12,15,20,25H,13-14,16-17H2,1H3/t20-/m0/s1
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186n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1B receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(HUMAN)
BDBM50002729
PNG
(CHEMBL215857)
Show SMILES COc1cccc(OC)c1OCCNC[C@@H]1COc2cc3CCCCc3cc2O1
Show InChI InChI=1S/C23H29NO5.ClH/c1-25-19-8-5-9-20(26-2)23(19)27-11-10-24-14-18-15-28-21-12-16-6-3-4-7-17(16)13-22(21)29-18;/h5,8-9,12-13,18,24H,3-4,6-7,10-11,14-15H2,1-2H3;1H/t18-;/m1./s1
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204n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(HUMAN)
BDBM50411191
PNG
(CHEMBL214762)
Show SMILES COc1cc(ccc1OCCNC[C@H]1COc2ccccc2O1)-c1ccccc1
Show InChI InChI=1S/C24H25NO4/c1-26-24-15-19(18-7-3-2-4-8-18)11-12-22(24)27-14-13-25-16-20-17-28-21-9-5-6-10-23(21)29-20/h2-12,15,20,25H,13-14,16-17H2,1H3/t20-/m0/s1
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214n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50002734
PNG
(CHEMBL214506)
Show SMILES COc1cc(ccc1OCCNC[C@@H]1COc2ccccc2O1)-c1ccccc1
Show InChI InChI=1S/C24H25NO4.ClH/c1-26-24-15-19(18-7-3-2-4-8-18)11-12-22(24)27-14-13-25-16-20-17-28-21-9-5-6-10-23(21)29-20;/h2-12,15,20,25H,13-14,16-17H2,1H3;1H/t20-;/m1./s1
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234n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1A receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(HUMAN)
BDBM50002730
PNG
(CHEMBL436955)
Show SMILES Cl.COc1cccc(OC)c1OCCNC[C@@H]1COc2cc3ccccc3cc2O1
Show InChI InChI=1S/C23H25NO5.ClH/c1-25-19-8-5-9-20(26-2)23(19)27-11-10-24-14-18-15-28-21-12-16-6-3-4-7-17(16)13-22(21)29-18;/h3-9,12-13,18,24H,10-11,14-15H2,1-2H3;1H/t18-;/m1./s1
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295n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50002731
PNG
(CHEMBL218732)
Show SMILES COc1ccc2ccccc2c1OCCNC[C@@H]1COc2cc3CCCCc3cc2O1
Show InChI InChI=1S/C26H29NO4.ClH/c1-28-23-11-10-18-6-4-5-9-22(18)26(23)29-13-12-27-16-21-17-30-24-14-19-7-2-3-8-20(19)15-25(24)31-21;/h4-6,9-11,14-15,21,27H,2-3,7-8,12-13,16-17H2,1H3;1H/t21-;/m1./s1
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324n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1A receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(HUMAN)
BDBM50411189
PNG
(CHEMBL218079)
Show SMILES COc1cccc(OC)c1OCCNC[C@H]1COc2cc3CCCCc3cc2O1
Show InChI InChI=1S/C23H29NO5/c1-25-19-8-5-9-20(26-2)23(19)27-11-10-24-14-18-15-28-21-12-16-6-3-4-7-17(16)13-22(21)29-18/h5,8-9,12-13,18,24H,3-4,6-7,10-11,14-15H2,1-2H3/t18-/m0/s1
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339n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50411190
PNG
(CHEMBL215188)
Show SMILES COc1cccc(OC)c1OCCNC[C@H]1COc2cc3ccccc3cc2O1
Show InChI InChI=1S/C23H25NO5/c1-25-19-8-5-9-20(26-2)23(19)27-11-10-24-14-18-15-28-21-12-16-6-3-4-7-17(16)13-22(21)29-18/h3-9,12-13,18,24H,10-11,14-15H2,1-2H3/t18-/m0/s1
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347n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat hippocampus


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50411189
PNG
(CHEMBL218079)
Show SMILES COc1cccc(OC)c1OCCNC[C@H]1COc2cc3CCCCc3cc2O1
Show InChI InChI=1S/C23H29NO5/c1-25-19-8-5-9-20(26-2)23(19)27-11-10-24-14-18-15-28-21-12-16-6-3-4-7-17(16)13-22(21)29-18/h5,8-9,12-13,18,24H,3-4,6-7,10-11,14-15H2,1-2H3/t18-/m0/s1
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363n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat hippocampus


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50002733
PNG
(CHEMBL214552)
Show SMILES COc1ccc(cc1OCCNC[C@@H]1COc2ccccc2O1)-c1ccccc1
Show InChI InChI=1S/C24H25NO4.ClH/c1-26-21-12-11-19(18-7-3-2-4-8-18)15-24(21)27-14-13-25-16-20-17-28-22-9-5-6-10-23(22)29-20;/h2-12,15,20,25H,13-14,16-17H2,1H3;1H/t20-;/m1./s1
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363n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat hippocampus


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(HUMAN)
BDBM50002734
PNG
(CHEMBL214506)
Show SMILES COc1cc(ccc1OCCNC[C@@H]1COc2ccccc2O1)-c1ccccc1
Show InChI InChI=1S/C24H25NO4.ClH/c1-26-24-15-19(18-7-3-2-4-8-18)11-12-22(24)27-14-13-25-16-20-17-28-21-9-5-6-10-23(21)29-20;/h2-12,15,20,25H,13-14,16-17H2,1H3;1H/t20-;/m1./s1
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363n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50411192
PNG
(CHEMBL385371)
Show SMILES COc1ccc2ccccc2c1OCCNC[C@H]1COc2cc3CCCCc3cc2O1
Show InChI InChI=1S/C26H29NO4/c1-28-23-11-10-18-6-4-5-9-22(18)26(23)29-13-12-27-16-21-17-30-24-14-19-7-2-3-8-20(19)15-25(24)31-21/h4-6,9-11,14-15,21,27H,2-3,7-8,12-13,16-17H2,1H3/t21-/m0/s1
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372n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1B receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50002729
PNG
(CHEMBL215857)
Show SMILES COc1cccc(OC)c1OCCNC[C@@H]1COc2cc3CCCCc3cc2O1
Show InChI InChI=1S/C23H29NO5.ClH/c1-25-19-8-5-9-20(26-2)23(19)27-11-10-24-14-18-15-28-21-12-16-6-3-4-7-17(16)13-22(21)29-18;/h5,8-9,12-13,18,24H,3-4,6-7,10-11,14-15H2,1-2H3;1H/t18-;/m1./s1
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398n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1B receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(HUMAN)
BDBM50411190
PNG
(CHEMBL215188)
Show SMILES COc1cccc(OC)c1OCCNC[C@H]1COc2cc3ccccc3cc2O1
Show InChI InChI=1S/C23H25NO5/c1-25-19-8-5-9-20(26-2)23(19)27-11-10-24-14-18-15-28-21-12-16-6-3-4-7-17(16)13-22(21)29-18/h3-9,12-13,18,24H,10-11,14-15H2,1-2H3/t18-/m0/s1
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417n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50002730
PNG
(CHEMBL436955)
Show SMILES Cl.COc1cccc(OC)c1OCCNC[C@@H]1COc2cc3ccccc3cc2O1
Show InChI InChI=1S/C23H25NO5.ClH/c1-25-19-8-5-9-20(26-2)23(19)27-11-10-24-14-18-15-28-21-12-16-6-3-4-7-17(16)13-22(21)29-18;/h3-9,12-13,18,24H,10-11,14-15H2,1-2H3;1H/t18-;/m1./s1
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427n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1B receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50002729
PNG
(CHEMBL215857)
Show SMILES COc1cccc(OC)c1OCCNC[C@@H]1COc2cc3CCCCc3cc2O1
Show InChI InChI=1S/C23H29NO5.ClH/c1-25-19-8-5-9-20(26-2)23(19)27-11-10-24-14-18-15-28-21-12-16-6-3-4-7-17(16)13-22(21)29-18;/h5,8-9,12-13,18,24H,3-4,6-7,10-11,14-15H2,1-2H3;1H/t18-;/m1./s1
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501n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat hippocampus


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50002731
PNG
(CHEMBL218732)
Show SMILES COc1ccc2ccccc2c1OCCNC[C@@H]1COc2cc3CCCCc3cc2O1
Show InChI InChI=1S/C26H29NO4.ClH/c1-28-23-11-10-18-6-4-5-9-22(18)26(23)29-13-12-27-16-21-17-30-24-14-19-7-2-3-8-20(19)15-25(24)31-21;/h4-6,9-11,14-15,21,27H,2-3,7-8,12-13,16-17H2,1H3;1H/t21-;/m1./s1
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550n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1B receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50002734
PNG
(CHEMBL214506)
Show SMILES COc1cc(ccc1OCCNC[C@@H]1COc2ccccc2O1)-c1ccccc1
Show InChI InChI=1S/C24H25NO4.ClH/c1-26-24-15-19(18-7-3-2-4-8-18)11-12-22(24)27-14-13-25-16-20-17-28-21-9-5-6-10-23(21)29-20;/h2-12,15,20,25H,13-14,16-17H2,1H3;1H/t20-;/m1./s1
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550n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1B receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50411189
PNG
(CHEMBL218079)
Show SMILES COc1cccc(OC)c1OCCNC[C@H]1COc2cc3CCCCc3cc2O1
Show InChI InChI=1S/C23H29NO5/c1-25-19-8-5-9-20(26-2)23(19)27-11-10-24-14-18-15-28-21-12-16-6-3-4-7-17(16)13-22(21)29-18/h5,8-9,12-13,18,24H,3-4,6-7,10-11,14-15H2,1-2H3/t18-/m0/s1
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575n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1B receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50002734
PNG
(CHEMBL214506)
Show SMILES COc1cc(ccc1OCCNC[C@@H]1COc2ccccc2O1)-c1ccccc1
Show InChI InChI=1S/C24H25NO4.ClH/c1-26-24-15-19(18-7-3-2-4-8-18)11-12-22(24)27-14-13-25-16-20-17-28-21-9-5-6-10-23(21)29-20;/h2-12,15,20,25H,13-14,16-17H2,1H3;1H/t20-;/m1./s1
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871n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat hippocampus


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50411190
PNG
(CHEMBL215188)
Show SMILES COc1cccc(OC)c1OCCNC[C@H]1COc2cc3ccccc3cc2O1
Show InChI InChI=1S/C23H25NO5/c1-25-19-8-5-9-20(26-2)23(19)27-11-10-24-14-18-15-28-21-12-16-6-3-4-7-17(16)13-22(21)29-18/h3-9,12-13,18,24H,10-11,14-15H2,1-2H3/t18-/m0/s1
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891n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1B receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(HUMAN)
BDBM50002731
PNG
(CHEMBL218732)
Show SMILES COc1ccc2ccccc2c1OCCNC[C@@H]1COc2cc3CCCCc3cc2O1
Show InChI InChI=1S/C26H29NO4.ClH/c1-28-23-11-10-18-6-4-5-9-22(18)26(23)29-13-12-27-16-21-17-30-24-14-19-7-2-3-8-20(19)15-25(24)31-21;/h4-6,9-11,14-15,21,27H,2-3,7-8,12-13,16-17H2,1H3;1H/t21-;/m1./s1
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955n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50002730
PNG
(CHEMBL436955)
Show SMILES Cl.COc1cccc(OC)c1OCCNC[C@@H]1COc2cc3ccccc3cc2O1
Show InChI InChI=1S/C23H25NO5.ClH/c1-25-19-8-5-9-20(26-2)23(19)27-11-10-24-14-18-15-28-21-12-16-6-3-4-7-17(16)13-22(21)29-18;/h3-9,12-13,18,24H,10-11,14-15H2,1-2H3;1H/t18-;/m1./s1
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1.00E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat hippocampus


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50411192
PNG
(CHEMBL385371)
Show SMILES COc1ccc2ccccc2c1OCCNC[C@H]1COc2cc3CCCCc3cc2O1
Show InChI InChI=1S/C26H29NO4/c1-28-23-11-10-18-6-4-5-9-22(18)26(23)29-13-12-27-16-21-17-30-24-14-19-7-2-3-8-20(19)15-25(24)31-21/h4-6,9-11,14-15,21,27H,2-3,7-8,12-13,16-17H2,1H3/t21-/m0/s1
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1.70E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat hippocampus


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50002731
PNG
(CHEMBL218732)
Show SMILES COc1ccc2ccccc2c1OCCNC[C@@H]1COc2cc3CCCCc3cc2O1
Show InChI InChI=1S/C26H29NO4.ClH/c1-28-23-11-10-18-6-4-5-9-22(18)26(23)29-13-12-27-16-21-17-30-24-14-19-7-2-3-8-20(19)15-25(24)31-21;/h4-6,9-11,14-15,21,27H,2-3,7-8,12-13,16-17H2,1H3;1H/t21-;/m1./s1
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3.63E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat hippocampus


J Med Chem 49: 7140-9 (2006)

Checked by Author
Article DOI: 10.1021/jm060358r
BindingDB Entry DOI: 10.7270/Q25Q4XBK
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%