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PubMed code 1732525

Compile data set for download or QSAR
Found 11 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229951
PNG
(CHEMBL49458)
Show SMILES CC1CC(=O)NN=C1c1ccc2NC(=O)CSc2c1
Show InChI InChI=1S/C13H13N3O2S/c1-7-4-11(17)15-16-13(7)8-2-3-9-10(5-8)19-6-12(18)14-9/h2-3,5,7H,4,6H2,1H3,(H,14,18)(H,15,17)
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PC sid
UniChem

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Article
PubMed
n/an/a 100n/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of canine cardiac Phosphodiesterase 3


J Med Chem 35: 172-6 (1992)


Article DOI: 10.1021/jm00079a023
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50226407
PNG
(CHEMBL299631 | Y-590)
Show SMILES CC1CC(=O)NN=C1c1ccc2N(C)C(=O)CCc2c1
Show InChI InChI=1S/C15H17N3O2/c1-9-7-13(19)16-17-15(9)11-3-5-12-10(8-11)4-6-14(20)18(12)2/h3,5,8-9H,4,6-7H2,1-2H3,(H,16,19)
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PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 100n/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of canine cardiac Phosphodiesterase 3


J Med Chem 35: 172-6 (1992)


Article DOI: 10.1021/jm00079a023
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50228430
PNG
(BEMORADAN | Bemoradan | ORF-22867)
Show SMILES CC1CC(=O)NN=C1c1ccc2NC(=O)COc2c1
Show InChI InChI=1S/C13H13N3O3/c1-7-4-11(17)15-16-13(7)8-2-3-9-10(5-8)19-6-12(18)14-9/h2-3,5,7H,4,6H2,1H3,(H,14,18)(H,15,17)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 300n/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of canine cardiac Phosphodiesterase 3


J Med Chem 35: 172-6 (1992)


Article DOI: 10.1021/jm00079a023
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229946
PNG
(CHEMBL52168)
Show SMILES CC1CC(=O)NN=C1c1ccc2NC(=O)CCc2c1
Show InChI InChI=1S/C14H15N3O2/c1-8-6-13(19)16-17-14(8)10-2-4-11-9(7-10)3-5-12(18)15-11/h2,4,7-8H,3,5-6H2,1H3,(H,15,18)(H,16,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 300n/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of canine cardiac Phosphodiesterase 3


J Med Chem 35: 172-6 (1992)


Article DOI: 10.1021/jm00079a023
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50228431
PNG
(CHEMBL49406)
Show SMILES CC1CC(=O)NN=C1c1ccc2N(C)C(=O)COc2c1
Show InChI InChI=1S/C14H15N3O3/c1-8-5-12(18)15-16-14(8)9-3-4-10-11(6-9)20-7-13(19)17(10)2/h3-4,6,8H,5,7H2,1-2H3,(H,15,18)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 300n/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of canine cardiac Phosphodiesterase 3


J Med Chem 35: 172-6 (1992)


Article DOI: 10.1021/jm00079a023
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229948
PNG
(CHEMBL294939)
Show SMILES CC1CC(=O)NN=C1c1ccc2N(C)C(=O)CSc2c1
Show InChI InChI=1S/C14H15N3O2S/c1-8-5-12(18)15-16-14(8)9-3-4-10-11(6-9)20-7-13(19)17(10)2/h3-4,6,8H,5,7H2,1-2H3,(H,15,18)
PDB
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UniChem

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Similars

Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of canine cardiac Phosphodiesterase 3


J Med Chem 35: 172-6 (1992)


Article DOI: 10.1021/jm00079a023
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229952
PNG
(CHEMBL49533)
Show SMILES CC1CC(=O)NN=C1c1ccc2NC(=O)C[Se]c2c1
Show InChI InChI=1S/C13H13N3O2Se/c1-7-4-11(17)15-16-13(7)8-2-3-9-10(5-8)19-6-12(18)14-9/h2-3,5,7H,4,6H2,1H3,(H,14,18)(H,15,17)
PDB
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UniProtKB/SwissProt

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DrugBank
GoogleScholar
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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of canine cardiac Phosphodiesterase 3


J Med Chem 35: 172-6 (1992)


Article DOI: 10.1021/jm00079a023
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229949
PNG
(CHEMBL294914)
Show SMILES O=C1CCC(=NN1)c1ccc2NC(=O)CSc2c1
Show InChI InChI=1S/C12H11N3O2S/c16-11-4-3-8(14-15-11)7-1-2-9-10(5-7)18-6-12(17)13-9/h1-2,5H,3-4,6H2,(H,13,17)(H,15,16)
PDB
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UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 7.00E+3n/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of canine cardiac Phosphodiesterase 3


J Med Chem 35: 172-6 (1992)


Article DOI: 10.1021/jm00079a023
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229954
PNG
(CHEMBL52041)
Show SMILES CN1C(=O)CSc2cc(ccc12)C1=NNC(=O)CC1
Show InChI InChI=1S/C13H13N3O2S/c1-16-10-4-2-8(6-11(10)19-7-13(16)18)9-3-5-12(17)15-14-9/h2,4,6H,3,5,7H2,1H3,(H,15,17)
PDB
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UniProtKB/SwissProt

B.MOAD
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.00E+4n/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of canine cardiac Phosphodiesterase 3


J Med Chem 35: 172-6 (1992)


Article DOI: 10.1021/jm00079a023
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229950
PNG
(CHEMBL297940)
Show SMILES CN1C(=O)CS(=O)(=O)c2cc(ccc12)C1=NNC(=O)CC1
Show InChI InChI=1S/C13H13N3O4S/c1-16-10-4-2-8(9-3-5-12(17)15-14-9)6-11(10)21(19,20)7-13(16)18/h2,4,6H,3,5,7H2,1H3,(H,15,17)
PDB
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UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.00E+4n/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of canine cardiac Phosphodiesterase 3


J Med Chem 35: 172-6 (1992)


Article DOI: 10.1021/jm00079a023
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229947
PNG
(CHEMBL49527)
Show SMILES CN1C(=O)C[S+]([O-])c2cc(ccc12)C1=NNC(=O)CC1
Show InChI InChI=1S/C13H13N3O3S/c1-16-10-4-2-8(9-3-5-12(17)15-14-9)6-11(10)20(19)7-13(16)18/h2,4,6H,3,5,7H2,1H3,(H,15,17)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.50E+4n/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of canine cardiac Phosphodiesterase 3


J Med Chem 35: 172-6 (1992)


Article DOI: 10.1021/jm00079a023
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%