Compile Data Set for Download or QSAR
maximum 50k data
Found 19 Enz. Inhib. hit(s) with all data for entry = 3520
TargetCannabinoid receptor 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35870(5,6-bis-(4-bromo-phenyl)-pyrazine-2-carboxylicacid...)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM21278(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl...)
Affinity DataIC50:  3nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCannabinoid receptor 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35873(5,6-bis(4-chlorophenyl)-N-(piperidin-1-yl)pyrazine...)
Affinity DataIC50:  4nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35871(5,6-di-p-tolyl-pyrazine-2-carboxylic acid piperidi...)
Affinity DataIC50:  6nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35877(5,6-bis-(4-methoxy-phenyl)-pyrazine-2-carboxylicac...)
Affinity DataIC50:  8nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35868(5,6-diaryl-pyrazine-2-amide derivative, 2b | 6-(4-...)
Affinity DataIC50:  10nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35875(5,6-bis-(4-bromo-phenyl)-pyrazine-2-carboxylicacid...)
Affinity DataIC50:  11nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35876(5,6-di-p-tolyl-pyrazine-2-carboxylic acid cyclohex...)
Affinity DataIC50:  13nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35878(5,6-bis(4-chlorophenyl)-N-cyclohexylpyrazine-2-car...)
Affinity DataIC50:  19nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35872(5,6-bis(4-methoxyphenyl)-N-(piperidin-1-yl)pyrazin...)
Affinity DataIC50:  21nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35883(5,6-bis-(4-chloro-phenyl)-pyrazine-2-carboxylicaci...)
Affinity DataIC50:  80nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35867(5,6-diaryl-pyrazine-2-amide derivative, 2a | 5-(4-...)
Affinity DataIC50:  114nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35882(5,6-bis(4-methoxyphenyl)-N-phenylpyrazine-2-carbox...)
Affinity DataIC50:  119nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35874(5,6-bis(2-chlorophenyl)-N-(piperidin-1-yl)pyrazine...)
Affinity DataIC50:  174nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35881(5,6-di-p-tolyl-pyrazine-2-carboxylic acid phenylam...)
Affinity DataIC50:  326nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35884(5,6-bis-(2-chloro-phenyl)-pyrazine-2-carboxylicaci...)
Affinity DataIC50:  763nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35869(5,6-diaryl-pyrazine-2-amide derivative, 5a | 5,6-d...)
Affinity DataIC50:  766nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35879(5,6-bis-(2-chloro-phenyl)-pyrazine-2-carboxylicaci...)
Affinity DataIC50:  1.58E+3nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM35880(5,6-diaryl-pyrazine-2-amide derivative, 7a | 5,6-d...)
Affinity DataIC50:  2.79E+3nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed