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Found 107 Enz. Inhib. hit(s) with all data for entry = 2017
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16171(2-[4-chloro-7-({1-[(4-methylpiperazin-1-yl)carbony...)
Affinity DataKi:  1.40nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16170(2-(4-chloro-7-{[1-(morpholin-4-ylcarbonyl)cyclopen...)
Affinity DataKi:  1.60nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16165(1-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)
Affinity DataKi:  2.60nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16154(1-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)
Affinity DataKi:  5.80nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16153(1-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)
Affinity DataKi:  7.40nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16156(4-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)
Affinity DataKi:  7.40nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16155(1-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)
Affinity DataKi:  8nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16159((2R)-1-({4-chloro-1-[(diaminomethylidene)amino]iso...)
Affinity DataKi:  9.90nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16169(1-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)
Affinity DataKi:  10nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16152(2-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)
Affinity DataKi:  10nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16157(4-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)
Affinity DataKi:  11nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16164(1-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)
Affinity DataKi:  11nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16166(cycloleucine deriv. 40 | ethyl 1-({4-chloro-1-[(di...)
Affinity DataKi:  14nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16129(1-isoquinolinylguanidine 3 | 3-{4-chloro-1-[(diami...)
Affinity DataKi:  17nM ΔG°:  -46.1kJ/molepH: 8.1 T: 2°CAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16148((2R)-2-({4-chloro-1-[(diaminomethylidene)amino]iso...)
Affinity DataKi:  19nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16147((2S)-2-({4-chloro-1-[(diaminomethylidene)amino]iso...)
Affinity DataKi:  21nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16150((2R)-2-({4-chloro-1-[(diaminomethylidene)amino]iso...)
Affinity DataKi:  22nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16161((2R)-1-({4-chloro-1-[(diaminomethylidene)amino]iso...)
Affinity DataKi:  23nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16151((2S)-2-[benzyl({4-chloro-1-[(diaminomethylidene)am...)
Affinity DataKi:  27nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16146((2R)-2-({4-chloro-1-[(diaminomethylidene)amino]iso...)
Affinity DataKi:  28nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16143(2-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)
Affinity DataKi:  29nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16168(1-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)
Affinity DataKi:  30nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16145(2-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)
Affinity DataKi:  31nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16144(2-[benzyl({4-chloro-1-[(diaminomethylidene)amino]i...)
Affinity DataKi:  35nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16141(1-guanidino-7-sulfonamidoisoquinoline 15 | 3-({4-c...)
Affinity DataKi:  43nM ΔG°:  -43.7kJ/molepH: 8.1 T: 2°CAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16139(1-guanidino-7-sulfonamidoisoquinoline 13 | 2-({4-c...)
Affinity DataKi:  48nM ΔG°:  -43.5kJ/molepH: 8.1 T: 2°CAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16163((2R)-1-({4-chloro-1-[(diaminomethylidene)amino]iso...)
Affinity DataKi:  54nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16142(2-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)
Affinity DataKi:  54nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16140(1-guanidino-7-sulfonamidoisoquinoline 14 | 3-({4-c...)
Affinity DataKi:  58nM ΔG°:  -43.0kJ/molepH: 8.1 T: 2°CAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16138(1-guanidino-7-sulfonamidoisoquinoline 12 | 3-({4-c...)
Affinity DataKi:  59nM ΔG°:  -42.9kJ/molepH: 8.1 T: 2°CAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16149((2S)-2-({4-chloro-1-[(diaminomethylidene)amino]iso...)
Affinity DataKi:  66nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16167(2-(4-chloro-7-{[1-(hydroxymethyl)cyclopentyl]sulfa...)
Affinity DataKi:  67nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16133(1-guanidino-7-sulfonamidoisoquinoline 7 | 2-[4-chl...)
Affinity DataKi:  71nM ΔG°:  -42.4kJ/molepH: 8.1 T: 2°CAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16137(1-guanidino-7-sulfonamidoisoquinoline 11 | 2-({4-c...)
Affinity DataKi:  86nM ΔG°:  -42.0kJ/molepH: 8.1 T: 2°CAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16160((2S)-1-({4-chloro-1-[(diaminomethylidene)amino]iso...)
Affinity DataKi:  111nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16134(1-guanidino-7-sulfonamidoisoquinoline 8 | 2-[4-chl...)
Affinity DataKi:  130nM ΔG°:  -40.9kJ/molepH: 8.1 T: 2°CAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16132(1-guanidino-7-sulfonamidoisoquinoline 6 | 2-(4-chl...)
Affinity DataKi:  140nM ΔG°:  -40.7kJ/molepH: 8.1 T: 2°CAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16162(2-(4-chloro-7-{[(2R)-2-(hydroxymethyl)pyrrolidine-...)
Affinity DataKi:  160nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16131(1-guanidino-7-sulfonamidoisoquinoline 5 | 2-[7-(ph...)
Affinity DataKi:  160nM ΔG°:  -40.3kJ/molepH: 8.1 T: 2°CAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16130(1-guanidino-7-sulfonamidoisoquinoline 4 | 2-(7-sul...)
Affinity DataKi:  280nM ΔG°:  -38.9kJ/molepH: 8.1 T: 2°CAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16135(1-guanidino-7-sulfonamidoisoquinoline 9 | 2-[4-chl...)
Affinity DataKi:  330nM ΔG°:  -38.5kJ/molepH: 8.1 T: 2°CAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16158(1-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)
Affinity DataKi:  330nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16136(1-guanidino-7-sulfonamidoisoquinoline 10 | 2-{4-ch...)
Affinity DataKi:  550nM ΔG°:  -37.2kJ/molepH: 8.1 T: 2°CAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16127(2,2 -methanediylbis(1H-benzimidazole-6-carboximida...)
Affinity DataKi:  2.30E+3nM ΔG°:  -33.5kJ/molepH: 8.1 T: 2°CAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16131(1-guanidino-7-sulfonamidoisoquinoline 5 | 2-[7-(ph...)
Affinity DataKi:  3.20E+3nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16128(4-(trifluoromethyl)benzene-1-guanidine | CHEMBL439...)
Affinity DataKi:  6.00E+3nM ΔG°:  -31.0kJ/molepH: 8.1 T: 2°CAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16138(1-guanidino-7-sulfonamidoisoquinoline 12 | 3-({4-c...)
Affinity DataKi:  9.80E+3nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16130(1-guanidino-7-sulfonamidoisoquinoline 4 | 2-(7-sul...)
Affinity DataKi:  1.30E+4nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16154(1-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)
Affinity DataKi:  1.40E+4nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16131(1-guanidino-7-sulfonamidoisoquinoline 5 | 2-[7-(ph...)
Affinity DataKi:  1.50E+4nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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