Found 6 Enz. Inhib. hit(s) with all data for entry = 2177 
Affinity DataKi: 11nM ΔG°: -45.0kJ/molepH: 5.0 T: 2°CAssay Description:BACE-1 activity was measured at pH 5 using the FS1 FRET substrate. Compounds were preincubated with recombinant BACE-1 for 20 min before adding subst...More data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataKi: 30nM ΔG°: -42.5kJ/molepH: 5.0 T: 2°CAssay Description:BACE-1 activity was measured at pH 5 using the FS1 FRET substrate. Compounds were preincubated with recombinant BACE-1 for 20 min before adding subst...More data for this Ligand-Target Pair
Affinity DataKi: 158nM ΔG°: -38.4kJ/molepH: 5.0 T: 2°CAssay Description:BACE-1 activity was measured at pH 5 using the FS1 FRET substrate. Compounds were preincubated with recombinant BACE-1 for 20 min before adding subst...More data for this Ligand-Target Pair
Affinity DataKi: 900nM ΔG°: -34.2kJ/molepH: 5.0 T: 2°CAssay Description:BACE-1 activity was measured at pH 5 using the FS1 FRET substrate. Compounds were preincubated with recombinant BACE-1 for 20 min before adding subst...More data for this Ligand-Target Pair
Affinity DataIC50: 110nMpH: 4.0 T: 2°CAssay Description:Cathepsin D activity was measured at pH 4 using a FRET peptide substrate. Compounds were preincubated with recombinant human liver cathepsin D for 20...More data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+3nMpH: 7.4 T: 2°CAssay Description:Renin activity was measured at pH 7.4 using a FRET peptide substrate. Compounds were added to recombinant human rennin and mixed before substrate was...More data for this Ligand-Target Pair
