Compile Data Set for Download or QSAR
maximum 50k data
Found 29 Enz. Inhib. hit(s) with all data for entry = 2460
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20832(7-fluoro-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2...)
Affinity DataIC50:  16nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20833(7-bromo-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2,...)
Affinity DataIC50:  38nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Amgen

LigandPNGBDBM20832(7-fluoro-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2...)
Affinity DataIC50:  52nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20838(7-(morpholin-4-ylmethyl)-3-[2-(pyridin-4-yl)-1,3-t...)
Affinity DataIC50:  62nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20830(6-fluoro-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2...)
Affinity DataIC50:  72nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20820(3-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]-1,2,3,4-tetr...)
Affinity DataIC50:  77nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20819(3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2,3,4-tetr...)
Affinity DataIC50:  79nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20834(7-phenyl-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2...)
Affinity DataIC50:  113nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Amgen

LigandPNGBDBM20819(3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2,3,4-tetr...)
Affinity DataIC50:  142nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20831(6-methyl-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2...)
Affinity DataIC50:  165nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20827(5-bromo-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2,...)
Affinity DataIC50:  228nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20825(5-fluoro-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2...)
Affinity DataIC50:  240nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20837(5-(morpholin-4-ylmethyl)-3-[2-(pyridin-4-yl)-1,3-t...)
Affinity DataIC50:  284nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20826(5-chloro-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2...)
Affinity DataIC50:  332nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20829(5-methoxy-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,...)
Affinity DataIC50:  362nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20839(3-[4-(pyridin-3-yl)-1,3-thiazol-2-yl]-1,2,3,4-tetr...)
Affinity DataIC50:  399nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Amgen

LigandPNGBDBM20838(7-(morpholin-4-ylmethyl)-3-[2-(pyridin-4-yl)-1,3-t...)
Affinity DataIC50:  529nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20822(3-[3-(pyridin-4-yl)-1,2,4-thiadiazol-5-yl]-1,2,3,4...)
Affinity DataIC50:  616nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20841(3-[2-(2-ethylpyridin-4-yl)-1,3-thiazol-4-yl]-1,2,3...)
Affinity DataIC50:  746nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20835(5-(4-methylpiperazin-1-yl)-3-[2-(pyridin-4-yl)-1,3...)
Affinity DataIC50:  829nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20818(1-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-2,3-dihydro-...)
Affinity DataIC50:  1.16E+3nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20836(6-(4-methylpiperazin-1-yl)-3-[2-(pyridin-4-yl)-1,3...)
Affinity DataIC50:  1.17E+3nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20828(5-methyl-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2...)
Affinity DataIC50:  1.26E+3nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20816(1-phenyl-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]urea...)
Affinity DataIC50:  2.99E+3nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20840(3-[4-(pyridin-2-yl)-1,3-thiazol-2-yl]-1,2,3,4-tetr...)
Affinity DataIC50:  7.36E+3nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20821(3-[3-(pyridin-4-yl)-1,2,4-oxadiazol-5-yl]-1,2,3,4-...)
Affinity DataIC50: >1.00E+4nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20817(3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2,3,4-tetr...)
Affinity DataIC50: >1.00E+4nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20824(3-[3-(pyridin-4-yl)phenyl]-1,2,3,4-tetrahydroquina...)
Affinity DataIC50: >1.00E+4nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20823(3-[5-(pyridin-4-yl)thiophen-2-yl]-1,2,3,4-tetrahyd...)
Affinity DataIC50: >1.00E+4nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed